DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment not and USP8

DIOPT Version :9

Sequence 1:	NP_001287106.1	Gene:	not / 40030	FlyBaseID:	FBgn0013717	Length:	496	Species:	Drosophila melanogaster
Sequence 2:	NP_001122082.1	Gene:	USP8 / 9101	HGNCID:	12631	Length:	1118	Species:	Homo sapiens

Alignment Length:	418	Identity:	125/418 - (29%)
Similarity:	196/418 - (46%)	Gaps:	51/418 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly   105 RSREYALINRKLEAKDLQKSI--------GWVPWV-----PT---TKETNLLLANARRRLVRPNQ 153
            |.||.:.:.|...:.|:.::|        ...|.|     ||   ..|.:.|.|:..|.|   |.
Human   706 RDREPSKLKRSYSSPDITQAIQEEEKRKPTVTPTVNRENKPTCYPKAEISRLSASQIRNL---NP 767

  Fly   154 TIG-----LRGLLNLGATCFMNCIVQALVHTPLLSDYF----MSDRHDCGSKSSHKCLVC-EVSR 208
            ..|     |.||.|||.||:||.|:|.|.:.|.|:|||    ..|..:..:...||..|. |...
Human   768 VFGGSGPALTGLRNLGNTCYMNSILQCLCNAPHLADYFNRNCYQDDINRSNLLGHKGEVAEEFGI 832

  Fly   209 LFQEFYSGSRSPLSLHRLLHLIWNHAKHLAGYEQQDAHEFFIATLDVLHRHCVKA--KAEHESKS 271
            :.:..::|....:|.......|.......|||.|||:.|..:..:|.||....||  :..::.::
Human   833 IMKALWTGQYRYISPKDFKITIGKINDQFAGYSQQDSQELLLFLMDGLHEDLNKADNRKRYKEEN 897

  Fly   272 NSSGSGSGTNSSNSSSSHC---YGQCN-CIIDQIFTGMLQSDVVCQACNGVSTTYDPFWDISLDL 332
            |..      .....::.|.   :.|.| .||..:|.|..:|.|.|..|:..|.|::.|..:||.|
Human   898 NDH------LDDFKAAEHAWQKHKQLNESIIVALFQGQFKSTVQCLTCHKKSRTFEAFMYLSLPL 956

  Fly   333 GETTTHGGVTPKTLIDCLERYTRAEHLGSAAKIKCSTCKSYQESTKQFSLRTLPSVVSFHLKRFE 397
            ..|      :..||.|||..:::.|.|....:..||.|::.::|.|:..:..||.|:..|||||.
Human   957 AST------SKCTLQDCLRLFSKEEKLTDNNRFYCSHCRARRDSLKKIEIWKLPPVLLVHLKRFS 1015

  Fly   398 HSALIDRKISSFIQFPVE-FDMTPFMSEKKNAYGDFRFSLYAVVNHVGTIDTGHYTAYVRH-QKD 460
            :.....:|:.:.:.||:| .|::.::...||...  :::|::|.||.|.:|.||||||.:: .:.
Human  1016 YDGRWKQKLQTSVDFPLENLDLSQYVIGPKNNLK--KYNLFSVSNHYGGLDGGHYTAYCKNAARQ 1078

  Fly   461 TWVKCDDHVITMASLKQVLDSEGYLLFY 488
            .|.|.|||.::..|:..|..|..|:|||
Human  1079 RWFKFDDHEVSDISVSSVKSSAAYILFY 1106

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
not	NP_001287106.1	zf-UBP	46..103	CDD:307999
not	NP_001287106.1	Peptidase_C19D	158..489	CDD:239125	107/344 (31%)
USP8	NP_001122082.1	USP8_dimer	8..115	CDD:312504
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	120..177
		RHOD	199..310	CDD:197731
		tolA_full	375..>547	CDD:274303
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	402..447
		SH3-binding. /evidence=ECO:0000250	405..413
		MIP-T3	474..>646	CDD:313469
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	475..648
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	679..746		8/39 (21%)
		UCH	777..1106	CDD:306860	105/342 (31%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1591
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.940