Protein Alignment not and USP8

DIOPT Version :10

• Sequence 1: NP_001401041.1
• Gene: not / 40030
• FlyBaseID: FBgn0013717
• Length: 703
• Species: Drosophila melanogaster
• Sequence 2: NP_005145.3
• Gene: USP8 / 9101
• HGNCID: 12631
• Length: 1118
• Species: Homo sapiens
• Alignment Length: 725
• Identity: 179/725 - (24%)
• Similarity: 284/725 - (39%)
• Gaps: 140/725 - (19%)

  Fly    12 EIETRKASEKSQKFTKKKPNYFQNWAARRRTAKVAKIRRKQRKCDKAFVPLQSSAKRAKTKENSV 76
            |:..|:..|:.:|..|::.   :..|.:::.|:..:|..||:|..:.....:|...:.:.||.|.
Human   481 ELRERQQEEQKEKLRKEEQ---EQKAKKKQEAEENEITEKQQKAKEEMEKKESEQAKKEDKETSA 542

  Fly    77 DSNTSVFSSSSSSSSGRSFGRGTERWAVGAEAGRGTAENETLAVAAAAATTTNAG-RFITADLIK 140
            .                   ||.|...|..::   .:|:||   :.|..:..:.| |..|.::.|
Human   543 K-------------------RGKEITGVKRQS---KSEHET---SDAKKSVEDRGKRCPTPEIQK 582

  Fly   141 TVNSDKQRDRVAKGHRDAKNPLDATKHLRLSDCLRTVQKLAIELESADAGSDASAQANASADASS 205
            ....|.....|. |...:..|. ..|....|..|||    ....|..|......||......|.|
Human   583 KSTGDVPHTSVT-GDSGSGKPF-KIKGQPESGILRT----GTFREDTDDTERNKAQREPLTRARS 641

  Fly   206 AVMSE------TGCRHYQSYVKEHSYDTFRVIDAYFAACVNRDARERKAIHCNCFECGSYGIQLY 264
            ..|..      :|...:...:.    .|||    |:.:..|       .:|....|...
Human   642 EEMGRIVPGLPSGWAKFLDPIT----GTFR----YYHSPTN-------TVHMYPPEMAP------ 685

  Fly   265 ACLHCIYFGCRGAHITSHLRSKKHNVALELSHGTLYCYACRDFIYDARSREYALINRKLEAKDLQ 329
                     ......|......|..:..|                  |.||.:.:.|...:.|:.
Human   686 ---------SSAPPSTPPTHKAKPQIPAE------------------RDREPSKLKRSYSSPDIT 723

  Fly   330 KSI--------GWVPWV-----PT---TKETNLLLANARRRLVRPNQTIG-----LRGLLNLGAT 373
            ::|        ...|.|     ||   ..|.:.|.|:..|.|   |...|     |.||.|||.|
Human   724 QAIQEEEKRKPTVTPTVNRENKPTCYPKAEISRLSASQIRNL---NPVFGGSGPALTGLRNLGNT 785

  Fly   374 CFMNCIVQALVHTPLLSDYF----MSDRHDCGSKSSHKCLVC-EVSRLFQEFYSGSRSPLSLHRL 433
            |:||.|:|.|.:.|.|:|||    ..|..:..:...||..|. |...:.:..::|....:|....
Human   786 CYMNSILQCLCNAPHLADYFNRNCYQDDINRSNLLGHKGEVAEEFGIIMKALWTGQYRYISPKDF 850

  Fly   434 LHLIWNHAKHLAGYEQQDAHEFFIATLDVLHRHCVKA--KAEHESKSNSSGSGSGTNSSNSSSSH 496
            ...|.......|||.|||:.|..:..:|.||....||  :..::.::|..      .....::.|
Human   851 KITIGKINDQFAGYSQQDSQELLLFLMDGLHEDLNKADNRKRYKEENNDH------LDDFKAAEH 909

  Fly   497 C---YGQCN-CIIDQIFTGMLQSDVVCQACNGVSTTYDPFWDISLDLGETTTHGGVTPKTLIDCL 557
            .   :.|.| .||..:|.|..:|.|.|..|:..|.|::.|..:||.|..|      :..||.|||
Human   910 AWQKHKQLNESIIVALFQGQFKSTVQCLTCHKKSRTFEAFMYLSLPLAST------SKCTLQDCL 968

  Fly   558 ERYTRAEHLGSAAKIKCSTCKSYQESTKQFSLRTLPSVVSFHLKRFEHSALIDRKISSFIQFPVE 622
            ..:::.|.|....:..||.|::.::|.|:..:..||.|:..|||||.:.....:|:.:.:.||:|
Human   969 RLFSKEEKLTDNNRFYCSHCRARRDSLKKIEIWKLPPVLLVHLKRFSYDGRWKQKLQTSVDFPLE 1033

  Fly   623 -FDMTPFMSEKKNAYGDFRFSLYAVVNHVGTIDTGHYTAYVRH-QKDTWVKCDDHVITMASLKQV 685
             .|::.::...||...  :::|::|.||.|.:|.||||||.:: .:..|.|.|||.::..|:..|
Human  1034 NLDLSQYVIGPKNNLK--KYNLFSVSNHYGGLDGGHYTAYCKNAARQRWFKFDDHEVSDISVSSV 1096

  Fly   686 LDSEGYLLFY 695
            ..|..|:|||
Human  1097 KSSAAYILFY 1106

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
not	NP_001401041.1	zf-UBP	253..310	CDD:460464	4/56 (7%)
		Peptidase_C19D	365..696	CDD:239125	107/344 (31%)
USP8	NP_005145.3	USP8_dimer	6..116	CDD:462647
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	120..177
		Rhodanese	192..304	CDD:425764
		tolA_full	375..>547	CDD:274303	17/87 (20%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	402..447
		SH3-binding. /evidence=ECO:0000250	405..413
		TolA	459..>656	CDD:442298	44/208 (21%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	475..648		43/200 (22%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	679..746		12/99 (12%)
		UCH	777..1106	CDD:425685	105/342 (31%)