DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment not and USP2

DIOPT Version :9

Sequence 1:	NP_001287106.1	Gene:	not / 40030	FlyBaseID:	FBgn0013717	Length:	496	Species:	Drosophila melanogaster
Sequence 2:	NP_004196.4	Gene:	USP2 / 9099	HGNCID:	12618	Length:	605	Species:	Homo sapiens

Alignment Length:	350	Identity:	123/350 - (35%)
Similarity:	171/350 - (48%)	Gaps:	35/350 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly   156 GLRGLLNLGATCFMNCIVQALVHTPLLSDY-----FMSDRHDCGSKSSHKCLVCEVSRLFQEFYS 215
            ||.||.|||.|||||.|:|.|.:|..|.||     :|.|.|. || ::|..||.|.::|.|..::
Human   265 GLAGLRNLGNTCFMNSILQCLSNTRELRDYCLQRLYMRDLHH-GS-NAHTALVEEFAKLIQTIWT 327

  Fly   216 GS-RSPLSLHRLLHLIWNHAKHLAGYEQQDAHEFFIATLDVLH----RHCVKAKAEHESKSNSSG 275
            .| ...:|.......|..:|....||.||||.||....||.||    |..::.|:..|:..:...
Human   328 SSPNDVVSPSEFKTQIQRYAPRFVGYNQQDAQEFLRFLLDGLHNEVNRVTLRPKSNPENLDHLPD 392

  Fly   276 SGSGTNS-----SNSSSSHCYGQCNCIIDQIFTGMLQSDVVCQACNGVSTTYDPFWDISLDLGET 335
            ...|...     ....|.         |..:|.|.|:|.:.|..|...||.:|||||:||.:.:.
Human   393 DEKGRQMWRKYLEREDSR---------IGDLFVGQLKSSLTCTDCGYCSTVFDPFWDLSLPIAKR 448

  Fly   336 TTHGGVTPKTLIDCLERYTRAEHLGSAAKIKCSTCKSYQESTKQFSLRTLPSVVSFHLKRFEHSA 400
                |....||:||:..:|:.:.|....|..|..|:..:...|:||::..|.::..|||||..|.
Human   449 ----GYPEVTLMDCMRLFTKEDVLDGDEKPTCCRCRGRKRCIKKFSIQRFPKILVLHLKRFSESR 509

  Fly   401 LIDRKISSFIQFPV-EFDMTPFMSEKKNAYGDFRFSLYAVVNHVGTIDTGHYTAYVRHQ-KDTWV 463
            :...|:::|:.||: :.|:..|.||..|   ...::||||.||.||...||||||.|.. ...|.
Human   510 IRTSKLTTFVNFPLRDLDLREFASENTN---HAVYNLYAVSNHSGTTMGGHYTAYCRSPGTGEWH 571

  Fly   464 KCDDHVITMASLKQVLDSEGYLLFY 488
            ..:|..:|..|..||..|:.|||||
Human   572 TFNDSSVTPMSSSQVRTSDAYLLFY 596

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
not	NP_001287106.1	zf-UBP	46..103	CDD:307999
not	NP_001287106.1	Peptidase_C19D	158..489	CDD:239125	120/347 (35%)
USP2	NP_004196.4	Necessary for interaction with MDM4. /evidence=ECO:0000269\|PubMed:19838211	1..200
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	71..107
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	237..264
		UCH	266..596	CDD:278850	120/347 (35%)
		Peptidase_C19R	268..597	CDD:239139	120/346 (35%)
		Necessary for interaction with MDM4. /evidence=ECO:0000269\|PubMed:19838211	403..503		32/112 (29%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1591
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.940