DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment not and USP6

DIOPT Version :9

Sequence 1:	NP_001287106.1	Gene:	not / 40030	FlyBaseID:	FBgn0013717	Length:	496	Species:	Drosophila melanogaster
Sequence 2:	NP_001291213.1	Gene:	USP6 / 9098	HGNCID:	12629	Length:	1406	Species:	Homo sapiens

Alignment Length:	339	Identity:	90/339 - (26%)
Similarity:	136/339 - (40%)	Gaps:	81/339 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly   120 DLQKSIGWVPWVPTTKETNLLLANARRRLVRPNQTIGLRGLLNLGATCFMNCIVQALVHTPLLSD 184
            |.||       |||.|                    |..||.|||.|||||..:|.:.:|..|:.
Human   521 DRQK-------VPTEK--------------------GATGLSNLGNTCFMNSSIQCVSNTQPLTQ 558

  Fly   185 YFMSDRH--------DCGSKSSH--KCLVCEVSRLFQEFYSGSRSPLSLHRLLHLIWNHAKHLAG 239
            ||:|.||        ..|.| .|  ||    ...|.||.:||::..::..:|...|..:|....|
Human   559 YFISGRHLYELNRTNPIGMK-GHMAKC----YGDLVQELWSGTQKSVAPLKLRRTIAKYAPKFDG 618

  Fly   240 YEQQDAHEFFIATLDVLHRHCVKAKAEHESK----SNSSGSGSGTNSSNSSSSHCYGQCNCIIDQ 300
            ::|||:.|.....||.||....:.   ||..    .:|.|......::.:..:|.....:.|:|
Human   619 FQQQDSQELLAFLLDGLHEDLNRV---HEKPYVELKDSDGRPDWEVAAEAWDNHLRRNRSIIVD- 679

  Fly   301 IFTGMLQSDVVCQACNGVSTTYDPF--------WDISLDLGETTTH-GGVTPKTL---IDCLERY 353
            :|.|.|:|.|.|:.|..:|..:|||        .|..:||..|... .|.||...   ::..|:|
Human   680 LFHGQLRSQVKCKTCGHISVRFDPFNFLSLPLPMDSYMDLEITVIKLDGTTPVRYGLRLNMDEKY 744

  Fly   354 T------------RAEHLGSAAKIKCSTCKSYQESTKQFSLRTLPSVVSFHLKRFEHSALIDRKI 406
            |            .:|.: ..|::..|..|::.:..::..|.     ||..|..|| ..:....|
Human   745 TGLKKQLRDLCGLNSEQI-LLAEVHDSNIKNFPQDNQKVQLS-----VSGFLCAFE-IPVPSSPI 802

  Fly   407 SSFIQFPVEFDMTP 420
            |:.....::|..:|
Human   803 SASSPTQIDFSSSP 816

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
not	NP_001287106.1	zf-UBP	46..103	CDD:307999
not	NP_001287106.1	Peptidase_C19D	158..489	CDD:239125	82/301 (27%)
USP6	NP_001291213.1	TBC	97..312	CDD:214540
		DUF4607	<332..407	CDD:292024
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	348..380
		UBP12	<528..1114	CDD:227847	84/325 (26%)
		Peptidase_C19	533..>723	CDD:271592	61/198 (31%)
		Peptidase_C19	<1023..1367	CDD:271592
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1120..1231
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1384..1406
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910