DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment not and USP13

DIOPT Version :9

Sequence 1:	NP_001287106.1	Gene:	not / 40030	FlyBaseID:	FBgn0013717	Length:	496	Species:	Drosophila melanogaster
Sequence 2:	NP_003931.2	Gene:	USP13 / 8975	HGNCID:	12611	Length:	863	Species:	Homo sapiens

Alignment Length:	715	Identity:	122/715 - (17%)
Similarity:	206/715 - (28%)	Gaps:	320/715 - (44%)

- Green bases have known domain annotations that are detailed below.

  Fly    31 CVNRDARERKAIHCNCFE----CGSYGIQLYACLHCIYFGCRG--AHITSHLRSKKHNVALELSH 89
            |...|.||.  :..|..:    ||.:           :|...|  .|...|.|...:.:|::|
Human   211 CARCDLREN--LWLNLTDGSVLCGKW-----------FFDSSGGNGHALEHYRDMGYPLAVKL-- 260

  Fly    90 GTL-------YCYACRDFIYDARSREYAL-----------INRKLEAKDLQKSIGWVPWVPTTKE 136
            ||:       |.:...:.:.|....::..           ....|:..|::..:.  .| ...:|
Human   261 GTITPDGADVYSFQEEEPVLDPHLAKHLAHFGIDMLHMHGTENGLQDNDIKLRVS--EW-EVIQE 322

  Fly   137 TNLLLANARRRLVRPNQTIGLRGLLNLGATCFMNCIVQALV-----------HTPLLSDY----- 185
            :...|        :|....|..||.|||.:|:::.::||:.           :.|.:.||
Human   323 SGTKL--------KPMYGPGYTGLKNLGNSCYLSSVMQAIFSIPEFQRAYVGNLPRIFDYSPLDP 379

  Fly   186 ---FMSDRHDCG---------------------SKSSHKCLVCEVS-RLFQEFYSGSRSPLSLHR 225
               |.:.....|                     .|..||.....:| |:|:.|.|.|....|.:|
Human   380 TQDFNTQMTKLGHGLLSGQYSKPPVKSELIEQVMKEEHKPQQNGISPRMFKAFVSKSHPEFSSNR 444

  Fly   226 LLHLIWNHAKHLAGYEQQDAHEFFIATLDVLHRH---------------------CVKAKAEHES 269
                            ||||.|||:..::::.|:                     |...|..:..
Human   445 ----------------QQDAQEFFLHLVNLVERNRIGSENPSDVFRFLVEERIQCCQTRKVRYTE 493

  Fly   270 KSN-----SSGSGSGTNSSNSSS---SHCYGQCN----------------CI--------IDQIF 302
            :.:     .....:.||.....:   :....:.|                |:        :|..:
Human   494 RVDYLMQLPVAMEAATNKDELIAYELTRREAEANRRPLPELVRAKIPFSACLQAFSEPENVDDFW 558

  Fly   303 TGMLQSDVVCQACNGVST-----------------TYDPFW-----DISLDLGE--TTTH---GG 340
            :..||:...     ||.|                 |:...|     |:|:|:.:  ...|   .|
Human   559 SSALQAKSA-----GVKTSRFASFPEYLVVQIKKFTFGLDWVPKKFDVSIDMPDLLDINHLRARG 618

  Fly   341 VTP-----------------------KTLID---------------------C------------ 349
            :.|                       ..|||                     |
Human   619 LQPGEEELPDISPPIVIPDDSKDRLMNQLIDPSDIDESSVMQLAEMGFPLEACRKAVYFTGNMGA 683

  Fly   350 ----------LERYTRAEHL-----GSAAKIKCS-------------------TCKSYQESTKQF 380
                      :|....||.|     |.||....|                   |...:|.:....
Human   684 EVAFNWIIVHMEEPDFAEPLTMPGYGGAASAGASVFGASGLDNQPPEEIVAIITSMGFQRNQAIQ 748

  Fly   381 SLRTLPSVVSFHLKR-----FEHSALIDRKISSFIQFPVEFDMTPFMSEKKNAY----------- 429
            :||    ..:.:|:|     |.|.           :|..:.|....|....||.
Human   749 ALR----ATNNNLERALDWIFSHP-----------EFEEDSDFVIEMENNANANIISEAKPEGPR 798

  Fly   430 ---GDFRFSLYAVVNHVGTID-TGHYTAYVRHQKDTWVKCDDHVITMASLKQVLDSEGYLLFYHK 490
               |...:.|:|.::|:||.. :|||..::: ::..||..:||.: .||.:...|. ||:.||.:
Human   799 VKDGSGTYELFAFISHMGTSTMSGHYICHIK-KEGRWVIYNDHKV-CASERPPKDL-GYMYFYRR 860

Fly 491 490
Human 861 860

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
not	NP_001287106.1	zf-UBP	46..103	CDD:307999	12/69 (17%)
not	NP_001287106.1	Peptidase_C19D	158..489	CDD:239125	96/561 (17%)
USP13	NP_003931.2	UBP14	30..861	CDD:227532	122/715 (17%)
		zf-UBP	211..284	CDD:280334	18/87 (21%)
		Peptidase_C19B	337..859	CDD:239123	96/560 (17%)
		UBA1_UBP13	652..700	CDD:270567	2/47 (4%)
		UBA2_UBP5	728..769	CDD:270569	8/55 (15%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910