DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment not and UBP5

DIOPT Version :9

Sequence 1:	NP_001287106.1	Gene:	not / 40030	FlyBaseID:	FBgn0013717	Length:	496	Species:	Drosophila melanogaster
Sequence 2:	NP_011071.3	Gene:	UBP5 / 856887	SGDID:	S000000946	Length:	805	Species:	Saccharomyces cerevisiae

Alignment Length:	411	Identity:	112/411 - (27%)
Similarity:	175/411 - (42%)	Gaps:	72/411 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly   129 PWVPTTKETNLLLANARRRLVRPNQTIGLR---GLLNLGATCFMNCIVQALVHTPLLSDYFMSDR 190
            |.:|...:.|  |:::|:.::..:|.:.|.   ||.|:|..|:||||:|.||.|..|...|:.:.
Yeast   416 PRIPPLPQQN--LSSSRQTILNNSQVLDLDLIVGLENIGNCCYMNCILQCLVGTHDLVRMFLDNT 478

  Fly   191 H--------DCGSK----SSHKCLVCEVSRLFQEFYSGSRSPLSLHRLLHLIWNHAKHLAGY--- 240
            :        ..|||    .:...||..:.|      .|:.:|.:: |.:.:.....|.:.|:
Yeast   479 YLNFINFDSSRGSKGLLAKNFAILVNNMHR------HGAFTPPNV-RTIPVQTIQFKKICGHINP 536

  Fly   241 -----EQQDAHEFFIATLDVLH---------RHCVKAKAEHESKSNSSGSGSGTNSSNSSSSHCY 291
                 .|||..||....||.||         :|..:...|.|...........  |:........
Yeast   537 MYSDSMQQDCQEFCQFLLDGLHEDLNQNGSKKHLKQLSDEEERMREKMSIRKA--SALEWERFLL 599

  Fly   292 GQCNCIIDQIFTGMLQSDVVCQACNGVSTTYDPFWDISLDLGETTTHGGVTPKTLIDCLERYTRA 356
            ...:.||| :|.|...|.:.||.|...||||..|..:|:.:....|      ..::||...:|:.
Yeast   600 TDFSAIID-LFQGQYASRLQCQVCEHTSTTYQTFSVLSVPVPRVKT------CNILDCFREFTKC 657

  Fly   357 EHLGSAAKIKCSTCKSYQESTKQFSLRTLPSVVSFHLKRFEHSALIDRKISSFIQFPVEFDMTPF 421
            |.||...:..|..|...|.||||..:..||..:..:||||::..   .|.:.|:|:|...|:||:
Yeast   658 ERLGVDEQWSCPKCLKKQPSTKQLKITRLPKKLIINLKRFDNQM---NKNNVFVQYPYSLDLTPY 719

  Fly   422 MSEKKN-------------AYGDFRFSLYAVVNHVGTIDTGHYTAYV-RHQKDTWVKCDDHV--- 469
            .:...|             ....||:.||.|..|.|::..||||:|| :..|..|...||.:
Yeast   720 WARDFNHEAIVNEDIPTRGQVPPFRYRLYGVACHSGSLYGGHYTSYVYKGPKKGWYFFDDSLYRP 784

  Fly   470 ITMASLKQVLDSEGYLLFYHK 490
            ||.::  :.:....|:|||.:
Yeast   785 ITFST--EFITPSAYVLFYER 803

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
not	NP_001287106.1	zf-UBP	46..103	CDD:307999
not	NP_001287106.1	Peptidase_C19D	158..489	CDD:239125	104/379 (27%)
UBP5	NP_011071.3	RHOD	159..280	CDD:197731
UBP5	NP_011071.3	COG5533	359..805	CDD:227820	112/411 (27%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1591
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.940