DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment not and UBP14

DIOPT Version :9

Sequence 1:	NP_001287106.1	Gene:	not / 40030	FlyBaseID:	FBgn0013717	Length:	496	Species:	Drosophila melanogaster
Sequence 2:	NP_009614.2	Gene:	UBP14 / 852349	SGDID:	S000000262	Length:	781	Species:	Saccharomyces cerevisiae

Alignment Length:	651	Identity:	126/651 - (19%)
Similarity:	205/651 - (31%)	Gaps:	267/651 - (41%)

- Green bases have known domain annotations that are detailed below.

  Fly    45 NCFECGSYGI--QLYACLHCIYFGC--------RGAHITSHLRS-KKHNVALE---LSHGT--LY 93
            |..:|.|..:  .|:.||||...||        ..:|...|.|| ..|.:|::   ||..|  ||
Yeast   188 NLNQCSSCDLTQNLWLCLHCGNIGCGREQIGIDGHSHALDHYRSNNNHPLAIKLGSLSSSTYDLY 252

  Fly    94 CYACRD--------------FIYDARSREYALINRKLEAKDLQKSIGW-VPWVPTT-KETNLLLA 142
            ||||.|              .||....:|.....:.|....::::..| ...|.:: ||...|.|
Yeast   253 CYACDDETRFPDNVNLGSALQIYGINIQEKIADEKTLVQLQVEQNENWQFRMVDSSGKEFEKLSA 317

  Fly   143 NARRRLVRPNQTIGLRGLLNLGATCFMNCIVQALVH--TPLLSDYFMSDRHDCGSK--------- 196
                     ::..|. ||:|||.:|::|.::|:||:  .|..|..|:      |||
Yeast   318 ---------SKNYGC-GLINLGNSCYLNSVIQSLVNGGVPNWSLDFL------GSKFPLDVVYPD 366

  Fly   197 SSHKC--------LVCEVSRLFQEFYSGSRSPLSLHRLLHLIWNHAKHLAGYEQQDAHEFFIATL 253
            ::.||        :.||     .|.|.....|.:..:.:.  .|| :..:...||||.||....|
Yeast   367 NNLKCQWIKLLNAMKCE-----PELYPNGIKPTTFKKCIG--QNH-QEFSSNRQQDAMEFLTFLL 423

  Fly   254 DVLHRHCVKAKAEHESKSNSSGSGSGTNSSNSSSSHCYGQCNCIIDQIFTGMLQSDVVCQACNGV 318
            |:|            .|...|.|.||..:.|               .:...|::..:.|..|..|
Yeast   424 DLL------------DKKFFSSSSSGIPNPN---------------DLVRFMMEDRLQCNICGKV 461

  Fly   319 STTYDPFWDISLDLGETTTHGGVTPKTLIDCLERYTRAEHLGSAAKIKCSTCKSYQESTKQFSLR 383
            ..:|:|...|.:.|.|..     .|:.:::.::.|..    |...:.||:.||....:.|:...:
Yeast   462 KYSYEPTEAIQIPLEEND-----EPQDMLERIKAYFE----GQTIEFKCANCKEKVTANKKPGFK 517

  Fly   384 TLPSVVSFHLKRFEHS--------------ALIDR----KISSFIQ---FPVEFDMTPFMSEKKN 427
            :||..:..:..|....              .||||    .:||::.   .|...::.|...|.::
Yeast   518 SLPQTLILNPIRIRLQNWIPVKTSNELSLPGLIDRDDMLDVSSYLSQGFDPQTENLLPDEDENRS 582

  Fly   428 AY--------------------------------------------------------------- 429
            ::
Yeast   583 SFTPNQCSISQLIEMGFTQNASVRALFNTGNQDAESAMNWLFQHMDDPDLNDPFVPPPNVPKKDK 647

  Fly   430 -----------------------------GDFR-------------------------------- 433
                                         ||..
Yeast   648 REVDEVSLTSMLSMGLNPNLCRKALILNNGDVNRSVEWVFNNMDDDGTFPEPEVPNEEQQQKKDL 712

  Fly   434 -------FSLYAVVNHVG-TIDTGHYTAYVRH---QKDTWVKCDDHVITMASLKQVLDSEGYLLF 487
                   ::|.||:.|.| ::.:|||..::|.   .|..||..:|..:..|...:.:...||:.|
Yeast   713 GYSTAKPYALTAVICHKGNSVHSGHYVVFIRKLVADKWKWVLYNDEKLVAADSIEDMKKNGYIYF 777

  Fly   488 Y 488
            |
Yeast   778 Y 778

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
not	NP_001287106.1	zf-UBP	46..103	CDD:307999	26/86 (30%)
not	NP_001287106.1	Peptidase_C19D	158..489	CDD:239125	89/506 (18%)
UBP14	NP_009614.2	UBP14	1..781	CDD:227532	126/651 (19%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910