DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment not and SAD1

DIOPT Version :9

Sequence 1:	NP_001287106.1	Gene:	not / 40030	FlyBaseID:	FBgn0013717	Length:	496	Species:	Drosophila melanogaster
Sequence 2:	NP_116660.1	Gene:	SAD1 / 850555	SGDID:	S000001901	Length:	448	Species:	Saccharomyces cerevisiae

Alignment Length:	537	Identity:	108/537 - (20%)
Similarity:	180/537 - (33%)	Gaps:	151/537 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 RHYQSYVKEHSYDTFRVID---AYFAACVNRDARERKAIHCNCFECGSYG-IQLYACLHCIYFGC 67
            ||.:..:|:.:....:..:   ||....|    ||:.........|.:.. :.:|.||.|.:: .
Yeast     8 RHSEDELKQEAVKKIKSQEPNYAYLETVV----REKLDFDSEKICCITLSPLNVYCCLVCGHY-Y 67

  Fly    68 RGAHITS----HLRSKKHNVALELSHGTLYCYACRDFIYDARSREYALINR-KLEA------KDL 121
            :|.|..|    |...:.|:|.|.|:  :|..|.....:......|..|:|. |..|      |||
Yeast    68 QGRHEKSPAFIHSIDENHHVFLNLT--SLKFYMLPQNVQILHDGEVQLLNSIKFAAYPTYCPKDL 130

  Fly   122 QKSIGWVPWVPTTKETNLLLANARRRLVRPNQTI--GLRGLLNLGATCFMNCIVQALVHTPLLSD 184
            :..                   .|:.....|:|.  |..|..|.....:.:.::..:.|...:.|
Yeast   131 EDF-------------------PRQCFDLSNRTYLNGFIGFTNAATYDYAHSVLLLISHMVPVRD 176

  Fly   185 YFMSDRHDCGSKSSHKCLVCEVS----RLFQEF--------YSGSRSPLSLHRL---LHLIWNHA 234
            :|:.:..|...:...:..:|...    :||:..        |...|..|:|:.:   |.|:|...
Yeast   177 HFLLNHFDNQGEFIKRLSICVKKIWSPKLFKHHLSVDDFVSYLKVREGLNLNPIDPRLFLLWLFN 241

  Fly   235 KHLAGYEQQDAHEFFIATLDVLHRHCVKAK---AEHESKSNSSGSGSGTNSSNSSSSHCYGQCNC 296
            |..:....          |..:..|..|.|   |:.|:|..:|.|.:|
Yeast   242 KICSSSND----------LKSILNHSCKGKVKIAKVENKPEASESVTG----------------- 279

  Fly   297 IIDQIFTGMLQSDVVCQACNGVSTTYDPFWDISLDLGETTTHGGVTPKTLIDCLERYTRAEHLGS 361
                                  .....|||.::|||.|.:.   ......:|.|.:.       :
Yeast   280 ----------------------KVIVKPFWVLTLDLPEFSP---FEDGNSVDDLPQI-------N 312

  Fly   362 AAKIKCSTCKSYQESTKQ-FSLRTLPSVVSFHLKRFEHSALIDRKISSFIQFPVEFDMTPFMSEK 425
            ..|:.....||...||.. |.|..||..:.||..||:.::  |..:.:..|..|||.     ||.
Yeast   313 ITKLLTKFTKSRSSSTSTVFELTRLPQFLIFHFNRFDRNS--DHPVKNRNQTLVEFS-----SEL 370

  Fly   426 KNAYGDFRFSLYAVVNHV--------GTIDTG----HY-TAYVRHQKDTWVKCDDHVITMASLKQ 477
            :..:..:|  |.|.|.||        |....|    |: |....::.:.|::.|....|
Yeast   371 EILHVKYR--LKANVVHVVIKQPSTDGNAFNGDEKSHWITQLYDNKSEKWIEIDGINTT------ 427

  Fly   478 VLDSEGYLLFYHKNVLE 494
              :.|..|||..:..::
Yeast   428 --EREAELLFLKETFIQ 442

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
not	NP_001287106.1	zf-UBP	46..103	CDD:307999	15/61 (25%)
not	NP_001287106.1	Peptidase_C19D	158..489	CDD:239125	73/362 (20%)
SAD1	NP_116660.1	Peptidase_C19M	30..445	CDD:239134	105/515 (20%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910