DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment not and USP30

DIOPT Version :9

Sequence 1:	NP_001287106.1	Gene:	not / 40030	FlyBaseID:	FBgn0013717	Length:	496	Species:	Drosophila melanogaster
Sequence 2:	XP_016875537.1	Gene:	USP30 / 84749	HGNCID:	20065	Length:	554	Species:	Homo sapiens

Alignment Length:	523	Identity:	119/523 - (22%)
Similarity:	176/523 - (33%)	Gaps:	193/523 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly   127 WVPWVPTTKETNLLLANARRRLVRPNQTIGLRGLLNLGATCFMNCIVQALVHTPL----LSDYFM 187
            :|.|.|.|:.      ..||:.:.|       ||:|||.|||||.::|.|...|.    |.::..
Human    50 YVIWGPITER------KKRRKGLVP-------GLVNLGNTCFMNSLLQGLSACPAFIRWLEEFTS 101

  Fly   188 SDRHDCGSKSSHKCLVCEVSRLF-----QEFYSGSRSPLSLHRLLHLIWNHAKHLAGYEQQDAHE 247
            ....|.....||:.|...:..|.     ||....  ..|....||.::..:...::.:|:|||||
Human   102 QYSRDQKEPPSHQYLSLTLLHLLKALSCQEVTDD--EVLDASCLLDVLRMYRWQISSFEEQDAHE 164

  Fly   248 FF---IATLD--------VLHR---HCVKAKAEHESKSNSSGSGSGTNSSNSSSSHCYGQCNCII 298
            .|   .::|:        |.|.   |.::.::|...|..:..:   ..|.:.:|:|...|
Human   165 LFHVITSSLEDERDRQPRVTHLFDVHSLEQQSEITPKQITCRT---RGSPHPTSNHWKSQ----- 221

  Fly   299 DQIFTGMLQSDVVCQACNGVS-TTYDPFWDISLDL-GETTTHGGVTPKTLIDCLERYTRAEHLGS 361
             ..|.|.|.|::||:.|...| ..:|.|..:||.: ..|..|    |.||..||..:..:|   |
Human   222 -HPFHGRLTSNMVCKHCEHQSPVRFDTFDSLSLSIPAATWGH----PLTLDHCLHHFISSE---S 278

  Fly   362 AAKIKCSTCK-------------SYQEST--KQFSLRTLPSVVSFHLKRF---EHSALIDRKISS 408
            ...:.|..|.             .:|.:|  ||..|..||..:..||:|.   .|...:.|  ..
Human   279 VRDVVCDNCTKIEAKGTLNGEKVEHQRTTFVKQLKLGKLPQCLCIHLQRLSWSSHGTPLKR--HE 341

  Fly   409 FIQFPVEFDM-------------------------------------TP------------FMSE 424
            .:||. ||.|                                     ||            |.:|
Human   342 HVQFN-EFLMMDIYKYHLLGHKPSQHNPKLNKNPGPTLELQDGPGAPTPGVCARGADAAGIFSTE 405

  Fly   425 KKN------------AYG----------------------------------------------D 431
            |.:            |.|                                              .
Human   406 KSSLASPPSGSLMTGAQGLYNVLNQPGAPKTQIFMNGACSPSLLPTLSAPMPFPLPVVPDYSSST 470

  Fly   432 FRFSLYAVVNHVGTIDTGHYTAYVR---------HQKDTWVKCDDHVITMASLKQVLDSEGYLLF 487
            :.|.|.|||.|.|.:.:||:..|.|         ...:.|:...|..:..|||::||.|..||||
Human   471 YLFRLMAVVVHHGDMHSGHFVTYRRSPPSARNPLSTSNQWLWVSDDTVRKASLQEVLSSSAYLLF 535

  Fly   488 YHK 490
            |.:
Human   536 YER 538

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
not	NP_001287106.1	zf-UBP	46..103	CDD:307999
not	NP_001287106.1	Peptidase_C19D	158..489	CDD:239125	111/489 (23%)
USP30	XP_016875537.1	None
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1867
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810