DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment not and USP32

DIOPT Version :9

Sequence 1:	NP_001287106.1	Gene:	not / 40030	FlyBaseID:	FBgn0013717	Length:	496	Species:	Drosophila melanogaster
Sequence 2:	XP_011523673.1	Gene:	USP32 / 84669	HGNCID:	19143	Length:	1634	Species:	Homo sapiens

Alignment Length:	504	Identity:	117/504 - (23%)
Similarity:	195/504 - (38%)	Gaps:	121/504 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    64 YFGCRG---------AHITSHLRSKKHNVALELSHGTLYCYACRDFIYDARSREYALINRK---- 115
            |.||..         .:::..||.|:.::.|.|.:...|.....|   :....||..|..:
Human   668 YTGCFSRMQTIKEIHEYLSQRLRIKEEDMRLWLYNSENYLTLLDD---EDHKLEYLKIQDEQHLV 729

  Fly   116 LEAKDLQKSIGWVPWVPTTKETNLLLANARR--RLVRPNQTIGLRGLLNLGATCFMNCIVQALVH 178
            :|.::  |.:.|       .|....:||:.:  |...|.:. |..||.|||.|||||..:|.:.:
Human   730 IEVRN--KDMSW-------PEEMSFIANSSKIDRHKVPTEK-GATGLSNLGNTCFMNSSIQCVSN 784

  Fly   179 TPLLSDYFMSDRH--------DCGSKSSH--KCLVCEVSRLFQEFYSGSRSPLSLHRLLHLIWNH 233
            |..|:.||:|.||        ..|.| .|  ||    ...|.||.:||::..::..:|...|..:
Human   785 TQPLTQYFISGRHLYELNRTNPIGMK-GHMAKC----YGDLVQELWSGTQKNVAPLKLRWTIAKY 844

  Fly   234 AKHLAGYEQQDAHEFFIATLDVLHRHCVKAKAEHESK----SNSSGSGSGTNSSNSSSSHCYGQC 294
            |....|::|||:.|.....||.||....:.   ||..    .:|.|......::.:..:|.....
Human   845 APRFNGFQQQDSQELLAFLLDGLHEDLNRV---HEKPYVELKDSDGRPDWEVAAEAWDNHLRRNR 906

  Fly   295 NCIIDQIFTGMLQSDVVCQACNGVSTTYDPFWDISLDLG-ETTTH--------GGVTPKTL---I 347
            :.::| :|.|.|:|.|.|:.|..:|..:|||..:||.|. ::..|        .|.||...   :
Human   907 SIVVD-LFHGQLRSQVKCKTCGHISVRFDPFNFLSLPLPMDSYMHLEITVIKLDGTTPVRYGLRL 970

  Fly   348 DCLERYT------------RAEHLGSAAKIKCSTCKSYQESTKQFSLRTLPSVVSFHLKRFEHSA 400
            :..|:||            .:|.: ..|::..|..|::.:..::..|.     ||..|..||...
Human   971 NMDEKYTGLKKQLSDLCGLNSEQI-LLAEVHGSNIKNFPQDNQKVRLS-----VSGFLCAFEIPV 1029

  Fly   401 LIDRKISSFIQFPVEFDMTPFMSE--KKNAYGDF---------------------RFSLYAVVNH 442
            .:. .||:......:|..:|..:|  .....||.                     .|:...|..|
Human  1030 PVS-PISASSPTQTDFSSSPSTNEMFTLTTNGDLPRPIFIPNGMPNTVVPCGTEKNFTNGMVNGH 1093

  Fly   443 VGTIDTGHYTAYVRHQKDTWVKCDDHVITMASLKQVLDSEGYLLFYHKN 491
            :.::....:|.|:                :|..::::.:|.|.|...||
Human  1094 MPSLPDSPFTGYI----------------IAVHRKMMRTELYFLSSQKN 1126

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
not	NP_001287106.1	zf-UBP	46..103	CDD:307999	10/47 (21%)
not	NP_001287106.1	Peptidase_C19D	158..489	CDD:239125	93/391 (24%)
USP32	XP_011523673.1	EF-hand_7	252..309	CDD:290234
		EFh	253..309	CDD:238008
		EF-hand_7	286..358	CDD:290234
		UBP12	534..1346	CDD:227847	117/504 (23%)
		DUSP	<535..602	CDD:283896
		Ubiquitin_3	653..740	CDD:291502	16/83 (19%)
		Peptidase_C19	765..>955	CDD:271592	61/198 (31%)
		Peptidase_C19	<1255..1595	CDD:271592
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1591
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.940