DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment not and USP48

DIOPT Version :9

Sequence 1:	NP_001287106.1	Gene:	not / 40030	FlyBaseID:	FBgn0013717	Length:	496	Species:	Drosophila melanogaster
Sequence 2:	NP_115612.4	Gene:	USP48 / 84196	HGNCID:	18533	Length:	1035	Species:	Homo sapiens

Alignment Length:	374	Identity:	98/374 - (26%)
Similarity:	150/374 - (40%)	Gaps:	92/374 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly   127 WVPWVPTTKETNLLLANARRRLVRPNQTIGLRGLLNLGATCFMNCIV----------QALVHTP- 180
            |:..:......|:...|..||  :.|..:   ||.||||||::|..:          |||...|
Human    63 WLGEIDENSFHNIDDPNCERR--KKNSFV---GLTNLGATCYVNTFLQVWFLNLELRQALYLCPS 122

  Fly   181 LLSDYFMSDRHDCG---SKSSHKCLVCE-VSRLFQEFYSGSR---SPLSLHRLLHLIWNHAKHLA 238
            ..|||.:.|    |   .|......:|| :..||....:.:|   .|....:.|.|...
Human   123 TCSDYMLGD----GIQEEKDYEPQTICEHLQYLFALLQNSNRRYIDPSGFVKALGLDTG------ 177

  Fly   239 GYEQQDAHEF---FIATL-DVLHRHCVKAKAEHESKSNSSGSGSGTNSSNSSSSHCYGQCNCIID 299
              :||||.||   |::.| |.|      :|.::....|                        |:.
Human   178 --QQQDAQEFSKLFMSLLEDTL------SKQKNPDVRN------------------------IVQ 210

  Fly   300 QIFTGMLQSDVVCQACNGVSTTYDPFWDISLDLGETTTHGGVTPKTLIDCLERYTRAEHLGSAAK 364
            |.|.|......||..|...|.....|:::.|::   ..|     |.|.||:..:.:.|.|....:
Human   211 QQFCGEYAYVTVCNQCGRESKLLSKFYELELNI---QGH-----KQLTDCISEFLKEEKLEGDNR 267

  Fly   365 IKCSTCKSYQESTKQFSLRTLPSVVSFHLKRFEHSALIDR------KISSFIQFPVEFDMTPFMS 423
            ..|..|:|.|.:|::..|.:||..::..|.||    :.||      |::::|.|....||.|::.
Human   268 YFCENCQSKQNATRKIRLLSLPCTLNLQLMRF----VFDRQTGHKKKLNTYIGFSEILDMEPYVE 328

  Fly   424 EKKNAYGDFRFSLYAVVNHVG-TIDTGHYTAYVRH-QKDTWVKCDDHVI 470
            .|.   |.:.:.|.||:.|.| :..:|||.|:|:. |...|.|.:|..|
Human   329 HKG---GSYVYELSAVLIHRGVSAYSGHYIAHVKDPQSGEWYKFNDEDI 374

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
not	NP_001287106.1	zf-UBP	46..103	CDD:307999
not	NP_001287106.1	Peptidase_C19D	158..489	CDD:239125	92/343 (27%)
USP48	NP_115612.4	UCH	89..418	CDD:278850	92/346 (27%)
		Peptidase_C19L	90..419	CDD:239133	92/342 (27%)
		DUSP	484..554	CDD:283896
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	612..640
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	879..919
		USP48_C	929..1035	CDD:176390
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910