Protein Alignment not and USP44

DIOPT Version :9

• Sequence 1: NP_001287106.1
• Gene: not / 40030
• FlyBaseID: FBgn0013717
• Length: 496
• Species: Drosophila melanogaster
• Sequence 2: XP_005269229.1
• Gene: USP44 / 84101
• HGNCID: 20064
• Length: 743
• Species: Homo sapiens
• Alignment Length: 699
• Identity: 150/699 - (21%)
• Similarity: 231/699 - (33%)
• Gaps: 263/699 - (37%)

  Fly    45 NCFECGSYGIQLYACLHCIYFGCR---GAHITSHLRSKKHNVALELSHGTLYCYACRDFIY-DAR 105
            :|.:|.:.. .::|||.|.:..|.   ..|...|.:...|.||||::...::||.|.|::. |..
Human    28 HCVDCNTTE-SIWACLSCSHVACGRYIEEHALKHFQESSHPVALEVNEMYVFCYLCDDYVLNDNT 91

  Fly   106 SREYALINRKLEAKDLQ------------KSIG-------------------------------- 126
            :.:..|:.|.|.|...|            :|:|
Human    92 TGDLKLLRRTLSAIKSQNYHCTTRSGRFLRSMGTGDDSYFLHDGAQSLLQSEDQLYTALWHRRRI 156

  Fly   127 --------W-------------------------------------------------------- 127
                    |
Human   157 LMGKIFRTWFEQSPIGRKKQEEPFQEKIVVKREVKKRRQELEYQVKAELESMPPRKSLRLQGLAQ 221

  Fly   128 ----------VP-WVPTTKETNLLLANARRRLV----------RPNQTIGLRGLLNLGATCFMNC 171
                      || ..|.:...:.:|:.:...:.          ||..|.|:.||.|||.||:||.
Human   222 STIIEIVSVQVPAQTPASPAKDKVLSTSENEISQKVSDSSVKRRPIVTPGVTGLRNLGNTCYMNS 286

  Fly   172 IVQALVHT-----------------------------PLLSDYFMSDRHDCGSK----------- 196
            ::|.|.|.                             |.::|..:...::|..|
Human   287 VLQVLSHLLIFRQCFLKLDLNQWLAMTASEKTRSCKHPPVTDTVVYQMNECQEKDTGFVCSRQSS 351

  Fly   197 ------------------------SSHKCLVCEVSRLFQEFYSGSRSPLSLHRLLHLIWNHAKHL 237
                                    |.:..|..|:..|||..:||..:.:|...:||.:|......
Human   352 LSSGLSGGASKGRKMELIQPKEPTSQYISLCHELHTLFQVMWSGKWALVSPFAMLHSVWRLIPAF 416

  Fly   238 AGYEQQDAHEFFIATLDVLHRHCVKAKAEHESKSNSSGSGSGTNSSNSSSSHCYGQCNCIIDQIF 302
            .||.||||.||....||.:.|       |.|:...|..:...|     |......|...:::.||
Human   417 RGYAQQDAQEFLCELLDKIQR-------ELETTGTSLPALIPT-----SQRKLIKQVLNVVNNIF 469

  Fly   303 TGMLQSDVVCQACNGVSTTYDPFWDISLDLGETTTHGG----VTPKTLIDCLERYTRAEHLGSAA 363
            .|.|.|.|.|.||:..|.|.:||||:||:..|.....|    ..|..:.:.|.::|..|.|....
Human   470 HGQLLSQVTCLACDNKSNTIEPFWDLSLEFPERYQCSGKDIASQPCLVTEMLAKFTETEALEGKI 534

  Fly   364 KIKCSTCKSYQ-----------ESTKQFSLRTLPSVVSFHLKRFEHSALI--------------- 402
            .: |..|.|.:           |:.||..:..||.|:..|||||..::|.
Human   535 YV-CDQCNSKRRRFSSKPVVLTEAQKQLMICHLPQVLRLHLKRFSTNSLCILINTLLAMLRSSNG 598

  Fly   403 -----------------DRKISSFIQFPVEFDMTPFMSEK--KNAYGD-FRFSLYAVVNHVGT-I 446
                             ..||...:.|....:|.|:...:  |:...: |.:.|.|||.|.|. .
Human   599 KYDQQTEKITGWSGRNNREKIGVHVGFEEILNMEPYCCRETLKSLRPECFIYDLSAVVMHHGKGF 663

  Fly   447 DTGHYTAYVRHQK-DTWVKCDDHVITMASLKQVLDSEGYLLFYHKNVLE 494
            .:||||||..:.: ..||.|:|..::|.::.:|..::.|:|||.:.|.|
Human   664 GSGHYTAYCYNSEGGFWVHCNDSKLSMCTMDEVCKAQAYILFYTQRVTE 712

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
not	NP_001287106.1	zf-UBP	46..103	CDD:307999	18/60 (30%)
		Peptidase_C19D	158..489	CDD:239125	112/446 (25%)
USP44	XP_005269229.1	zf-UBP	29..90	CDD:280334	18/61 (30%)
		UCH	272..706	CDD:278850	111/446 (25%)
		Peptidase_C19	274..707	CDD:271592	112/445 (25%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1867
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810