DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment not and Usp8

DIOPT Version :9

Sequence 1:	NP_001287106.1	Gene:	not / 40030	FlyBaseID:	FBgn0013717	Length:	496	Species:	Drosophila melanogaster
Sequence 2:	NP_001239509.1	Gene:	Usp8 / 84092	MGIID:	1934029	Length:	1091	Species:	Mus musculus

Alignment Length:	419	Identity:	122/419 - (29%)
Similarity:	193/419 - (46%)	Gaps:	53/419 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly   105 RSREYALINRKLEAKDLQKSI-----------------GWVPWVPTTKETNLLLANARRRLVRPN 152
            |.||.:.:.|...:.|:.:::                 ...|..|.. |.:.|.|:..|.|   |
Mouse   679 RDREPSKLKRSYSSPDITQALQEEEKRRPAVTPMVNRENKPPCYPKA-EISRLSASQIRNL---N 739

  Fly   153 QTIG-----LRGLLNLGATCFMNCIVQALVHTPLLSDYF----MSDRHDCGSKSSHKCLVC-EVS 207
            ...|     |.||.|||.||:||.|:|.|.:.|.|:|||    ..|..:..:...||..|. |..
Mouse   740 PVFGGSGPALTGLRNLGNTCYMNSILQCLCNAPHLADYFNRNCYQDDINRSNLLGHKGEVAEEFG 804

  Fly   208 RLFQEFYSGSRSPLSLHRLLHLIWNHAKHLAGYEQQDAHEFFIATLDVLHRHCVKA--KAEHESK 270
            .:.:..::|....:|.......|.......||..|||:.|..:..:|.||....||  :..|:.:
Mouse   805 IIMKALWTGQYRYISPKDFKVTIGKINDQFAGSSQQDSQELLLFLMDGLHEDLNKADNRKRHKEE 869

  Fly   271 SNSSGSGSGTNSSNSSSSHC---YGQCN-CIIDQIFTGMLQSDVVCQACNGVSTTYDPFWDISLD 331
            :|..      .....::.|.   :.|.| .||..:|.|..:|.|.|..|...|.|::.|..:||.
Mouse   870 NNEH------LDDLQAAEHAWQKHKQLNESIIVALFQGQFKSTVQCLTCRRRSRTFEAFMYLSLP 928

  Fly   332 LGETTTHGGVTPKTLIDCLERYTRAEHLGSAAKIKCSTCKSYQESTKQFSLRTLPSVVSFHLKRF 396
            |..|      :..||.|||..:::.|.|....:..||.|::.::|.|:..:..||.|:..|||||
Mouse   929 LAST------SKCTLQDCLRLFSKEEKLTDNNRFYCSHCRARRDSLKKIEIWKLPPVLLVHLKRF 987

  Fly   397 EHSALIDRKISSFIQFPVE-FDMTPFMSEKKNAYGDFRFSLYAVVNHVGTIDTGHYTAYVRH-QK 459
            .:.....:|:.:.:.||:| .|::.::...||:..  :::|::|.||.|.:|.||||||.:: .:
Mouse   988 SYDGRWKQKLQTSVDFPLENLDLSQYVIGPKNSLK--KYNLFSVSNHYGGLDGGHYTAYCKNAAR 1050

  Fly   460 DTWVKCDDHVITMASLKQVLDSEGYLLFY 488
            ..|.|.|||.::..|:..|..|..|:|||
Mouse  1051 QRWFKFDDHEVSDISVSSVRSSAAYILFY 1079

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
not	NP_001287106.1	zf-UBP	46..103	CDD:307999
not	NP_001287106.1	Peptidase_C19D	158..489	CDD:239125	107/344 (31%)
Usp8	NP_001239509.1	USP8_dimer	6..126	CDD:286108
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	130..187
		RHOD	210..321	CDD:197731
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	390..466
		SH3-binding	416..424
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	479..616
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	653..721		5/41 (12%)
		UCH	749..1079	CDD:278850	106/343 (31%)
		Peptidase_C19R	751..1080	CDD:239139	107/343 (31%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1591
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.940