Protein Alignment not and USP11

DIOPT Version :10

• Sequence 1: NP_001401041.1
• Gene: not / 40030
• FlyBaseID: FBgn0013717
• Length: 703
• Species: Drosophila melanogaster
• Sequence 2: NP_001358001.1
• Gene: USP11 / 8237
• HGNCID: 12609
• Length: 920
• Species: Homo sapiens
• Alignment Length: 912
• Identity: 155/912 - (16%)
• Similarity: 272/912 - (29%)
• Gaps: 372/912 - (40%)

  Fly   119 AVAAAAATTTNAGRFITADLIKTVNSDKQRDRVAKGHRDAKNPLDATKHLRLSDCLRTVQKLAIE 183
            |||||||.|.:.    .....:....|.|..::..|....:.|      ||..:....|:|...:
Human    14 AVAAAAAVTEDR----EPQHEELPGLDSQWRQIENGESGRERP------LRAGESWFLVEKHWYK 68

  Fly   184 LESA--DAGSDASAQANASADASSAVMSETGCRHYQSYVKEHSY-----DTFRVIDAYFAACVNR 241
            ...|  ..|...|:......:.::....|...|..:..|:...|     ..:..:.:::.....:
Human    69 QWEAYVQGGDQDSSTFPGCINNATLFQDEINWRLKEGLVEGEDYVLLPAAAWHYLVSWYGLEHGQ 133

  Fly   242 DARERKAIHC-NCFECGSYGIQLYAC-------LHCIYFGCRGAHITS---HLRSKKHNVALE-- 293
            ...|||.|.. |..:...|.::|...       .|.:.|    :|..|   .||:.:....:|
Human   134 PPIERKVIELPNIQKVEVYPVELLLVRHNDLGKSHTVQF----SHTDSIGLVLRTARERFLVEPQ 194

  Fly   294 --------LSHGTLYCYACRDFIYDARSR--EYALINRKLEAKDLQKSIGWVPWVPTTKETNLLL 348
                    .|.|:|      |.:||....  :.||...:|...:.:|..|..|
Human   195 EDTRLWAKNSEGSL------DRLYDTHITVLDAALETGQLIIMETRKKDGTWP------------ 241

  Fly   349 ANARRRLVRPNQT---------IGLRGLLNLGATCFMNCIVQALVHTPLLSDYFMSD-------- 396
             :|:..::..|.:         .|:.||.|||.|||||..:|.|.:.|.|::||:::
Human   242 -SAQLHVMNNNMSEEDEDFKGQPGICGLTNLGNTCFMNSALQCLSNVPQLTEYFLNNCYLEELNF 305

  Fly   397 RHDCGSKSSHKCLVCEV-SRLFQEFYSGSRSPLSLHRLLHLIWNHAKHLAGYEQQDAHEFFIATL 460
            |:..|.|..    :.|. :.|.::.:||....:..|...:.:.:.|....||:|.|:.|.....|
Human   306 RNPLGMKGE----IAEAYADLVKQAWSGHHRSIVPHVFKNKVGHFASQFLGYQQHDSQELLSFLL 366

  Fly   461 DVLHRHCVKA-KAEHESKSNSSGSGSGTNSSNSSSSHCYGQCNCIIDQIFTGMLQSDVVCQACNG 524
            |.||....:. |.|:....:::|......:..:..:|.....:.|:| .|.|:.:|.:||..|..
Human   367 DGLHEDLNRVKKKEYVELCDAAGRPDQEVAQEAWQNHKRRNDSVIVD-TFHGLFKSTLVCPDCGN 430

  Fly   525 VSTTYDPFWDISLDL-------------------------------GE-------TTTHGGVTPK 551
            ||.|:|||..:|:.|                               |:       .:.|.|::|:
Human   431 VSVTFDPFCYLSVPLPISHKRVLEVFFIPMDPRRKPEQHRLVVPKKGKISDLCVALSKHTGISPE 495

  Fly   552 TLI-------------------------------------------------------------- 554
            .::
Human   496 RMMVADVFSHRFYKLYQLEEPLSSILDRDDIFVYEVSGRIEAIEGSREDIVVPVYLRERTPARDY 560

  Fly   555 ----------------------------------------------------------------- 554
                                                                             
Human   561 NNSYYGLMLFGHPLLVSVPRDRFTWEGLYNVLMYRLSRYVTKPNSDDEDDGDEKEDDEEDKDDVP 625

  Fly   555 ----------------------------------------------------------------- 554
                                                                             
Human   626 GPSTGGSLRDPEPEQAGPSSGVTNRCPFLLDNCLGTSQWPPRRRRKQLFTLQTVNSNGTSDRTTS 690

  Fly   555 -------------------------------------------------DCLERYTRAEHLGSAA 570
                                                             :|:|.:|..|.|....
Human   691 PEEVHAQPYIAIDWEPEMKKRYYDEVEAEGYVKHDCVGYVMKKAPVRLQECIELFTTVETLEKEN 755

  Fly   571 KIKCSTCKSYQESTKQFSLRTLPSVVSFHLKRFEHSALIDRKISSFIQFPV-EFDMTPFMSEKKN 634
            ...|.:||.:|.:||:..|..||.::..|||||.::.....|:.:.::||: :.|.:.|:.:.:|
Human   756 PWYCPSCKQHQLATKKLDLWMLPEILIIHLKRFSYTKFSREKLDTLVEFPIRDLDFSEFVIQPQN 820

  Fly   635 AYGD--FRFSLYAVVNHVGTIDTGHYTAYVRHQKDT--WVKCDDHVITMASLKQVLDSEGYLLFY 695
            ....  :::.|.||.||.|.:..||||.:..: ||:  |...||:.::..:..|:.....|:|||
Human   821 ESNPELYKYDLIAVSNHYGGMRDGHYTTFACN-KDSGQWHYFDDNSVSPVNENQIESKAAYVLFY 884

  Fly   696 HK 697
            .:
Human   885 QR 886

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
not	NP_001401041.1	zf-UBP	253..310	CDD:460464	13/76 (17%)
		Peptidase_C19D	365..696	CDD:239125	102/624 (16%)
USP11	NP_001358001.1	UBP12	56..886	CDD:227847	141/858 (16%)