DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment not and usp39

DIOPT Version :9

Sequence 1:	NP_001287106.1	Gene:	not / 40030	FlyBaseID:	FBgn0013717	Length:	496	Species:	Drosophila melanogaster
Sequence 2:	NP_001073539.1	Gene:	usp39 / 790924	ZFINID:	ZDB-GENE-030131-966	Length:	497	Species:	Danio rerio

Alignment Length:	511	Identity:	116/511 - (22%)
Similarity:	185/511 - (36%)	Gaps:	162/511 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly    54 IQLYACLHC-IYFGCRG--AHITSHLRSKKHNVALELSHGTLYCYACRDFIYDARSREYALINRK 115
            |.:||||.| .||..||  :|...|.....|:|.|.|.  ||..|...|        .|.:|:..
Zfish    62 INVYACLICGKYFQGRGQKSHAYIHSVQVAHHVFLNLH--TLKFYCLPD--------NYEIIDSS 116

  Fly   116 LEAKDLQKSIGWVPWVPTTKETNLLLANARRRLVR----PNQTIGLRGLLNLGATCFMNCIVQAL 176
            ||      .|.:| ..||..:.::...:.:.:|.|    .....|:.||.|:.|..:.|.::|||
Zfish   117 LE------DITYV-LKPTFTKQHISGLDKQGKLYRAYDGTTYLPGIVGLNNIKANDYANVVLQAL 174

  Fly   177 VHTPLLSDYFMSDRHDCGSKSSHKCLVCEVSRLFQEFYSGSRSP------LSLHR---LLHLIW- 231
            .:.|.|.:||:.                      :|.|.|.|.|      |.:.|   |:..:|
Zfish   175 SNVPPLRNYFLE----------------------EENYRGIRRPPGDIMFLLVQRFGELMRKLWN 217

  Fly   232 --NHAKHLAGYE-----------------QQDAHEFFIATLDVLHRHCVKAKAEHESKSNSSGSG 277
              |...|::.:|                 |.||.:|....|:.||                 |:.
Zfish   218 PRNFKAHVSPHEMLQAVVLCSKKTFQITKQGDAVDFLSWFLNALH-----------------GAL 265

  Fly   278 SGTNSSNSSSSHCYGQCNCIIDQIFTGMLQ--------SDVVCQACNGV--------STTYDPFW 326
            .||...:|           ||.:.|.|.::        .|:..:....:        ..:...|.
Zfish   266 GGTKKKSS-----------IITKAFQGSMRIFSKKLPHPDLPPEEKEALLLKEEYQEEMSESTFL 319

  Fly   327 DISLDLGETTTHGG-----VTPKT-LIDCLERYTRAEHLGSAAKIKCSTCKSYQES-TKQFSLRT 384
            .::|||.....:..     :.|:. |.:.|.::.     |:..|    ..|:|:|: .|:|.|..
Zfish   320 YLTLDLPTAPLYKDEKEQLIIPQVPLFNILGKFN-----GNTEK----EYKTYKENFLKRFQLTK 375

  Fly   385 LPSVVSFHLKRFEHSALIDRKISSFIQFPV-EFDMTPFMSE-----KKNAYGDFRFSLYAVVNHV 443
            ||..:.|.:|||..:.....|..:.:.||: ..|:..:::|     :||.    .:.|.|.|.|.
Zfish   376 LPPYLIFCIKRFTKNNFFVEKNPTIVNFPITNVDLREYLTEEAQVTEKNT----TYDLVANVVHD 436

  Fly   444 GTIDTGHYTAYV-RHQKDTWVKCDDHVITMASLKQVLD--------SEGYLLFYHK 490
            |....|.|..:| .|....|.:..|        .||:|        ||.|:..:.:
Zfish   437 GKPTEGSYRIHVLHHGTGKWYELQD--------LQVIDILPQMITLSEAYIQIWKR 484

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
not	NP_001287106.1	zf-UBP	46..103	CDD:307999	20/51 (39%)
not	NP_001287106.1	Peptidase_C19D	158..489	CDD:239125	85/397 (21%)
usp39	NP_001073539.1	Peptidase_C19M	37..483	CDD:239134	116/508 (23%)
usp39	NP_001073539.1	UCH	155..482	CDD:278850	85/397 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910