DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment not and USP7

DIOPT Version :9

Sequence 1:	NP_001287106.1	Gene:	not / 40030	FlyBaseID:	FBgn0013717	Length:	496	Species:	Drosophila melanogaster
Sequence 2:	XP_016879141.1	Gene:	USP7 / 7874	HGNCID:	12630	Length:	1113	Species:	Homo sapiens

Alignment Length:	358	Identity:	88/358 - (24%)
Similarity:	140/358 - (39%)	Gaps:	76/358 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly   156 GLRGLLNLGATCFMNCIVQALVHTPLL--SDYFMSDRHDCGSKSSHKCLVCEVSRLFQEFYSGSR 218
            |..||.|.||||:||.::|.|..|..|  :.|.|....|..|||    :...:.|:|.|. ..|.
Human   212 GYVGLKNQGATCYMNSLLQTLFFTNQLRKAVYMMPTEGDDSSKS----VPLALQRVFYEL-QHSD 271

  Fly   219 SPLSLHRLLHLI-WNHAKHLAGYEQQDAHEFFIATLDVLHRHCVKAKAEHESKSNSSGSGSGTNS 282
            .|:...:|.... |   :.|..:.|.|..|.....||         ..|::.|        ||
Human   272 KPVGTKKLTKSFGW---ETLDSFMQHDVQELCRVLLD---------NVENKMK--------GT-- 314

  Fly   283 SNSSSSHCYGQCNCI---IDQIFTGMLQSDVVCQACNGVSTTYDPFWDISLDL-GETTTHGGVTP 343
                         |:   |.::|.|.:.|.:.|:..:..|...:.::||.|.: |:
Human   315 -------------CVEGTIPKLFRGKMVSYIQCKEVDYRSDRREDYYDIQLSIKGK--------- 357

  Fly   344 KTLIDCLERYTRAEHLGSAAKIKCSTCKSYQESTKQFSLRTLPSVVSFHLKRFEHSALIDR--KI 406
            |.:.:....|...|.|....|..... ...||:.|.....|||.|:...|.||.:....|:  ||
Human   358 KNIFESFVDYVAVEQLDGDNKYDAGE-HGLQEAEKGVKFLTLPPVLHLQLMRFMYDPQTDQNIKI 421

  Fly   407 SSFIQFPVEFDMTPFMSEKKNAYGDFRFSLYAVVNHVGTIDTGHYTAYVRHQKD-TWVKCDDHVI 470
            :...:||.:..:..|: :|.:......:.|:||:.|.|....|||..|:..:.| .|.|.||.|:
Human   422 NDRFEFPEQLPLDEFL-QKTDPKDPANYILHAVLVHSGDNHGGHYVVYLNPKGDGKWCKFDDDVV 485

  Fly   471 TMASLKQVLD---------------SEGYLLFY 488
            :..:.::.::               :..|:|.|
Human   486 SRCTKEEAIEHNYGGHDDDLSVRHCTNAYMLVY 518

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
not	NP_001287106.1	zf-UBP	46..103	CDD:307999
not	NP_001287106.1	Peptidase_C19D	158..489	CDD:239125	87/356 (24%)
USP7	XP_016879141.1	None
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910