Protein Alignment not and usp19

DIOPT Version :10

• Sequence 1: NP_001401041.1
• Gene: not / 40030
• FlyBaseID: FBgn0013717
• Length: 703
• Species: Drosophila melanogaster
• Sequence 2: XP_012816883.1
• Gene: usp19 / 780341
• XenbaseID: XB-GENE-5869969
• Length: 1478
• Species: Xenopus tropicalis
• Alignment Length: 1273
• Identity: 197/1273 - (15%)
• Similarity: 327/1273 - (25%)
• Gaps: 627/1273 - (49%)

  Fly    27 KKKPNYFQNWAARRRTAKVAKIRRKQRKCDKAFVPLQSSAKRAKTKENSVDSNTSVFSSSSSSSS 91
            ||.|  |..|...::     |.:...::..||...:::...:...|....|.:.:..|.|:.:..
 Frog   125 KKIP--FNKWPTLQK-----KKKESMKEQVKAGALMENGKPKVSLKLPLPDKSQTQPSESTDARK 182

  Fly    92 GRSFGRGTERWAVGAEAGRGTAEN---ETLAVAAAAATTTNAGRFITADLIKTVNSDKQRDRVA- 152
            |:...|...|.....||..|...:   ::::.|..:......|...:|.:|...:|..|..:||
 Frog   183 GKPDHRSVRRGQETTEASSGVKSSLTRKSISTAVHSGVQMKRGCHKSASVIAGGDSSPQSQKVAG 247

  Fly   153 -----------------------KGHRDAKN---------------------------------- 160
                                   .||:...:
 Frog   248 SEDLSSRGLNKRNVQIPSGNATWAGHKSGDSQAELQNAQRDQNKSLGKEKMPALDQQVLLQEAGP 312

  Fly   161 ---------------PLD-------------ATKHLRLSDCLRTVQKLAIELE---------SAD 188
                           |:|             |:...:..||.:.:.|:.:.||         |..
 Frog   313 TLQPACLHAVEKQNAPIDLNSVIVAPCKEMLASTSEQTLDCQQELSKMNLNLEVKEVVVKPHSDS 377

  Fly   189 AGSDASAQANA--------------SADASSAVMSETGCR--HYQS---------YVKEHSYDTF 228
            |.|||:.....              :.:....:::.|..:  ||:.         ||||...:|.
 Frog   378 ALSDATELGGPPKKVDSPTEDCLEDTTEEPEPIVNLTFVKNDHYEKGNDVVVVHVYVKEICKETS 442

  Fly   229 RVI---DAYFAACVNRDARERKAIHCNCFECGSYGIQLY--------ACLHCIYFGCRGAHITSH 282
            ||:   ..:......||....: :|.||.....:..|:.        .|.:|.    .||.:...
 Frog   443 RVLFREQDFTLIFKTRDPNFLR-LHPNCTPDTVFRWQVKLRNLIEPDLCRYCF----TGARVDIS 502

  Fly   283 LRSKK-------HNVALELSHGTLYCYAC-RDFIYDAR----------------SREYALINRKL 323
            |:.|:       ...|.:..|...|.... :..:..|:                |.:::|.|::
 Frog   503 LQKKQCQRWGGLEAPATQGLHPEFYLLLKEKGAVGGAKVAMPAGPPPHDKTQPGSNQHSLSNKE- 566

  Fly   324 EAKDLQKSIGWVPWVPTTKETNL------------------LLANARRRLVRPNQT--------- 361
            ||:.::|.      .|..::|.|                  ||::.:...:.|..|
 Frog   567 EARAVEKE------KPRAEDTGLDKVSSRTPTDHVSVKSEQLLSSPKPTCMVPPMTHSAVSSENV 625

  Fly   362 ----------IGLRGLLNLGATCFMNCIVQALVHTPLLSDYFMSDRHDCGSKSSHKC-------- 408
                      .|..||:|||.|||||.::|:|.:|..|.|||    .|...:|...|
 Frog   626 QEEEEKRVCPPGFTGLVNLGNTCFMNSVIQSLSNTRELRDYF----QDRSFESEINCNNPLGTGG 686

  Fly   409 -LVCEVSRLFQEFYSGSRSPLSLHRLLHLIWNHAKHLAGYEQQDAHEFFIATLDVLHRHCVKAKA 472
             |....:.|.:..:.|:.......:|..::.:.|....||.|.||.||....||.||....:.:.
 Frog   687 RLAVSFAVLLRALWKGTHHAFQPSKLKAIVASKASQFTGYAQHDAQEFMAFLLDGLHEDLNRIQN 751

  Fly   473 EHESKS-NSSGSGSGTNSSNSSSSHCYGQCNCIIDQIFTGMLQSDVVCQACNGVSTTYDPF---- 532
            :..::: :|.|......:..:...|.....:.::| :|.|..:|.:||..|..||.|:|||
 Frog   752 KPYTETVDSDGRPDEEVADEAWLRHKMRNDSFVVD-LFQGQYKSKLVCPVCAKVSITFDPFLYLP 815

  Fly   533 ----------------------------------------------------------------- 532
                                                                             
 Frog   816 VPLPQKQKVLTVYYFAREPHKKPIKFLVSISKENSSAAEVLESISKSVRVKAENLQLAEVVKNRF 880

  Fly   533 ----------------------------------------------------------------- 532
                                                                             
 Frog   881 QRIFRPSCSLDSVSPNDLLFCFEVLSKELSKERVVVFQVQQRPQVPSIPITKCAACQKKQMSEEE 945

  Fly   533 ----------------------W------------------------------------------ 533
                                  |
 Frog   946 KLKRCTRCYRVGYCNQVCQKSHWPDHKTACRPENIGYPFLISVPESRLTYSRLAQLLEGYARYSV 1010

  Fly   534 --------------------------------DISLDLGETT----------------------- 543
                                            |:.| |||::
 Frog  1011 NVFQPPFIPGRTSPDHAPQPLSSEKADLPPQSDLPL-LGESSEEEKDFHSVQSSQTTLPPLTCLS 1074

  Fly   544 -------THG---------------------------------------GVTPK----------- 551
                   .||                                       .|.|:
 Frog  1075 ASGDSGIVHGKPPGDRVSLYSTDSGFSEHSTDTVREMDSGGEKETIYEKSVKPEAAVAGFQQSES 1139

  Fly   552 ----------------------------------------------------------------- 551
                                                                             
 Frog  1140 VNVHASAFYINVIDPNNKEMKLEDKGESPLELTEDCSLALVWKNNERAKEFVLVESKELECEEDP 1204

  Fly   552 ------------TLIDCLERYTRAEHLGSAAKIKCSTCKSYQESTKQFSLRTLPSVVSFHLKRFE 604
                        ||..||..:|:.|.|.......|..|..::|::||..|..||:::...||||.
 Frog  1205 GSASEAARAGLFTLDQCLNLFTKPEVLAPEEAWYCPKCNQHREASKQLMLWRLPNILIIQLKRFS 1269

  Fly   605 HSALIDR-KISSFIQFPV-EFDMTPFMSEKKNAYGDFRFSLYAVVNHVGTIDTGHYTAYVR--HQ 665
            ....|.| ||:..:.||| ..|::.|...:|..:....:.||||:||.|.:..||||||.|  ::
 Frog  1270 FRTFIWRDKINDMVDFPVRNLDLSTFCIGQKEDHQRPIYDLYAVINHYGGMIGGHYTAYARLPNE 1334

  Fly   666 KDT------WVKCDDHVITMASLKQVLDSEGYLLFYHK 697
            |::      |...||..:|.....||:....|:|||.:
 Frog  1335 KNSQRSDVGWRLFDDSTVTTVDESQVVTRYAYVLFYRR 1372

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
not	NP_001401041.1	zf-UBP	253..310	CDD:460464	11/72 (15%)
		Peptidase_C19D	365..696	CDD:239125	115/737 (16%)
usp19	XP_012816883.1	p23_like	53..135	CDD:107220	5/11 (45%)
		p23_CS_SGT1_like	435..515	CDD:107223	17/84 (20%)
		USP19_linker	506..637	CDD:465191	18/137 (13%)
		UBP12	<637..1374	CDD:227847	117/742 (16%)