DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment not and Usp42

DIOPT Version :9

Sequence 1:	NP_001287106.1	Gene:	not / 40030	FlyBaseID:	FBgn0013717	Length:	496	Species:	Drosophila melanogaster
Sequence 2:	NP_084025.2	Gene:	Usp42 / 76800	MGIID:	1924050	Length:	1324	Species:	Mus musculus

Alignment Length:	356	Identity:	101/356 - (28%)
Similarity:	174/356 - (48%)	Gaps:	49/356 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly   146 RRLVRPNQTIGLR---------GLLNLGATCFMNCIVQALVHTPLLSDYFMSDRHDCGSKSSHK- 200
            ::::.|::.|.|:         ||.|||.|||.|..:|.|.:||.|::|.:|..|   ||:.|.
Mouse    89 QKVLFPSEKICLKWQQSHRVGAGLQNLGNTCFANAALQCLTYTPPLANYMLSHEH---SKTCHAE 150

  Fly   201 --CLVCEVSRLFQEFYSGSRSPLSLHRLLHLIWNHAKHLAGYEQQDAHEFFIATLDVLHRHCVKA 263
              |::|.:.....:..|.....:....:::.:...|:|.....|:|||||...|:|.:.:.|:
Mouse   151 GFCMMCTMQTHITQALSNPGDVIKPMFVINEMRRIARHFRFGNQEDAHEFLQYTVDAMQKACL-- 213

  Fly   264 KAEHESKSNSSGSGSGTNSSNSSSSHCYGQCNCIIDQIFTGMLQSDVVCQACNGVSTTYDPFWDI 328
                             |.||....|.  |...::.|||.|.|:|.|.|..|.|||.|:||:.||
Mouse   214 -----------------NGSNKLDRHT--QATTLVCQIFGGYLRSRVKCLNCKGVSDTFDPYLDI 259

  Fly   329 SLDLGETTTHGGVTPKTLIDCLERYTRAEHLGSAAKIKCSTCKSYQESTKQFSLRTLPSVVSFHL 393
            :|::        ...:::...||::.:.|.|......|||.||....::|:|::....:|::..|
Mouse   260 TLEI--------KAAQSVTKALEQFVKPEQLDGENSYKCSKCKKMVPASKRFTIHRSSNVLTISL 316

  Fly   394 KRFEHSALIDRKISSFIQFPVEFDMTPFMSEKKNAYGDFRFSLYAVVNHVG-TIDTGHYTAYVRH 457
            |||.:  ....||:..:::|...|:.|:||:....  ...:.||||:.|.| ....|||..|::.
Mouse   317 KRFAN--FTGGKIAKDVKYPEYLDIRPYMSQPNGE--PIIYVLYAVLVHTGFNCHAGHYFCYIKA 377

  Fly   458 QKDTWVKCDDHVITMASLKQVLDSEGYLLFY 488
            ....|.:.:|.:::.:.::.||:.:.|:|||
Mouse   378 SNGLWYQMNDSIVSTSDIRAVLNQQAYVLFY 408

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
not	NP_001287106.1	zf-UBP	46..103	CDD:307999
not	NP_001287106.1	Peptidase_C19D	158..489	CDD:239125	98/344 (28%)
Usp42	NP_084025.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..38
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	64..86
		Peptidase_C19E	109..409	CDD:239126	98/336 (29%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	417..517
		Herpes_BLLF1	<420..795	CDD:282904
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	549..587
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	624..676
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	717..780
		Sporozoite_P67	<723..>870	CDD:253298
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	816..847
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	880..1026
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1145..1262
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1303..1324
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910