DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment not and Usp20

DIOPT Version :9

Sequence 1:	NP_001287106.1	Gene:	not / 40030	FlyBaseID:	FBgn0013717	Length:	496	Species:	Drosophila melanogaster
Sequence 2:	NP_083122.1	Gene:	Usp20 / 74270	MGIID:	1921520	Length:	916	Species:	Mus musculus

Alignment Length:	696	Identity:	153/696 - (21%)
Similarity:	237/696 - (34%)	Gaps:	256/696 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly    31 CVNRDARERKAIHC--NCFECGSYGIQLYACLH--CIYFGCRGA---HITSHLRSKKHNVALELS 88
            |:....:|...:..  .|..||..|..|:|||.  |.|.||..:   |.:.|.:.||||:.:.|:
Mouse    13 CIGEVTKEDLLLKSKGTCQSCGVAGPNLWACLQVTCPYVGCGESFADHSSIHAQVKKHNLTVNLT 77

  Fly    89 HGTLYCYAC-RDFIYDAR-SREYALINRKLEAKDLQKSIGWVPWVP---------TTKETNLLLA 142
            ...::|||| |:...:.| :...|..:.:|..:|.......:..||         .:::.:|
Mouse    78 TFRVWCYACEREVFLEQRLAVHLASSSARLSEQDSPPPSHPLKAVPIAVADEGESESEDDDL--- 139

  Fly   143 NARRRLVRPNQTIGLRGLLNLGATCFMNCIVQALVHTPLLSDYFMSDRHDCGS--KSSHKCLVCE 205
                   :|.   ||.|:.|||.:|:||..:|||.:.|.|:.:|:    :||.  ::..|..:|:
Mouse   140 -------KPR---GLTGMKNLGNSCYMNAALQALSNCPPLTQFFL----ECGGLVRTDKKPALCK 190

  Fly   206 -VSRLFQEFYSGSRS----PLSLHRLLHLIWNHAKHLAGYEQQDAHEFFIATLDVLH-------- 257
             ..:|..|.:...|.    |.||...:.|:   .....||.|||..||....:|.||
Mouse   191 SYQKLISEVWHKKRPSYVVPTSLSHGIKLV---NPMFRGYAQQDTQEFLRCLMDQLHEELKEPMV 252

  Fly   258 --------------------RHCVKAKAEHE------SKSNSSGSGSG----------------- 279
                                |...::.:|.|      |.....|.|.|
Mouse   253 AAVAALTDARDSDSSDTDERRDGDRSPSEDEFLSCDSSSDRGEGDGQGRGGGSSKAEMELLISDE 317

  Fly   280 ----------------------TNS--------------------------SNSSSSHCY----- 291
                                  |||                          |..|:|.|.
Mouse   318 AGRAISEKERMKDRKFSWGQQRTNSEQVDEDADVDTAMASLDEQSREAQPPSPRSTSPCQTPEPD 382

  Fly   292 ---------GQCN-------------------------------------------------CII 298
                     ..|:                                                 .:|
Mouse   383 NEAHIRSSSRPCSPVHHHHEGHSKLSSSPPRASPVRMGPSYVLKKAQVPSTGGRRRKEQSYRSVI 447

  Fly   299 DQIFTGMLQSDVVCQACNGVSTTYDPFWDISLDL------------------------GETTTHG 339
            ..:|.|.:.|.|.|..|:.||||.:.|.|:||.:                        |::.:..
Mouse   448 SDVFNGSVLSLVQCLTCDRVSTTVETFQDLSLPIPGKEDLAKLHSAIYQNVPAKPGACGDSYSSQ 512

  Fly   340 G---------------VTPK-------TLIDCLERYTRAEHLGSAAKIKCSTCKSYQESTKQFSL 382
            |               .||.       ||.|||..:..|:.|.......|..||..:...|...:
Mouse   513 GWLAFIVEYIRRFVVSCTPSWFWGPVVTLEDCLAAFFAADELKGDNMYSCERCKKLRNGVKYCKV 577

  Fly   383 RTLPSVVSFHLKRFEHSALIDRKISSFIQFPVE-FDMTPFMSEKKNAYGDFRFSLYAVVNHVGTI 446
            ..||.::..|||||.|..:...|:||.:.||:| .|:.||::::..:... .:.|.:|:.|.||.
Mouse   578 LCLPEILCVHLKRFRHEVMYSFKVSSHVSFPLEGLDLRPFLAKECTSQVT-TYDLLSVICHHGTA 641

  Fly   447 DTGHYTAYVRHQ-KDTWVKCDDHVITMASLKQVLDSEGYLLFYHKN 491
            .:|||.||.::. ...|.:.||..:|......|.:.|.|:|||.|:
Mouse   642 GSGHYIAYCQNVINGQWYEFDDQYVTEVHETVVQNVEAYVLFYRKS 687

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
not	NP_001287106.1	zf-UBP	46..103	CDD:307999	24/62 (39%)
not	NP_001287106.1	Peptidase_C19D	158..489	CDD:239125	115/547 (21%)
Usp20	NP_083122.1	zf-UBP	30..90	CDD:366940	24/59 (41%)
		UBP12	<73..688	CDD:227847	133/636 (21%)
		UCH	145..684	CDD:366104	114/546 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	258..420		15/161 (9%)
		DUSP	704..787	CDD:197831
		DUSP	812..896	CDD:197831
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910