DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment not and USP17L5

DIOPT Version :9

Sequence 1:	NP_001287106.1	Gene:	not / 40030	FlyBaseID:	FBgn0013717	Length:	496	Species:	Drosophila melanogaster
Sequence 2:	NP_001229258.1	Gene:	USP17L5 / 728386	HGNCID:	37177	Length:	530	Species:	Homo sapiens

Alignment Length:	366	Identity:	109/366 - (29%)
Similarity:	175/366 - (47%)	Gaps:	66/366 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly   141 LANARRRLVRPNQTIGL---------RGLLNLGATCFMNCIVQALVHTPLLSDYFMSDRHDCGSK 196
            ||...|:|. |.:.:.|         .||.|:|.||::|..:|.|.:||.|::|.:|..|   |:
Human    55 LAPVARQLA-PREKLPLSSRRPAAVGAGLQNMGNTCYVNASLQCLTYTPPLANYMLSREH---SQ 115

  Fly   197 SSHK---CLVCEVSRLFQEFYSGSRSPLSLHRLLHLIWNHAKHLAGY---EQQDAHEFFIATLDV 255
            :.|:   |::|.:.         :....:||...|:|.......||:   :|:|||||.:.|:|.
Human   116 TCHRHKGCMLCTMQ---------AHITRALHNPGHVIQPSQALAAGFHRGKQEDAHEFLMFTVDA 171

  Fly   256 LHRHCVKA--KAEHESKSNSSGSGSGTNSSNSSSSHCYGQCNCIIDQIFTGMLQSDVVCQACNGV 318
            :.:.|:..  :.:|.||..:                       :|.|||.|..:|.:.|..|:|:
Human   172 MKKACLPGHKQVDHHSKDTT-----------------------LIHQIFGGYWRSQIKCLHCHGI 213

  Fly   319 STTYDPFWDISLDLGETTTHGGVTPKTLIDCLERYTRAEHLGSAAKIKCSTCKSYQESTKQFSLR 383
            |.|:||:.||:||:        ...:::...||:..:.|.|.......|..|.....::|..:|.
Human   214 SDTFDPYLDIALDI--------QAAQSVQQALEQLAKPEELNGENAYHCGVCLQRAPASKTLTLH 270

  Fly   384 TLPSVVSFHLKRFEHSALIDRKISSFIQFPVEFDMTPFMSEKKNAYGDFRFSLYAVVNHVG-TID 447
            |...|:...||||  |.:...||:..:|:|...||.|:||:...  |...:.||||:.|.| :..
Human   271 TSAKVLILVLKRF--SDVTGNKIAKNVQYPECLDMQPYMSQPNT--GPLVYVLYAVLVHAGWSCH 331

  Fly   448 TGHYTAYVRHQKDTWVKCDDHVITMASLKQVLDSEGYLLFY 488
            .|||.:||:.|:..|.|.||..:|.:|:..||..:.|:|||
Human   332 NGHYFSYVKAQEGQWYKMDDAEVTASSITSVLSQQAYVLFY 372

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
not	NP_001287106.1	zf-UBP	46..103	CDD:307999
not	NP_001287106.1	Peptidase_C19D	158..489	CDD:239125	103/340 (30%)
USP17L5	NP_001229258.1	Peptidase_C19E	79..373	CDD:239126	103/341 (30%)
		UCH	80..372	CDD:278850	101/338 (30%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	382..412
		HABP4_PAI-RBP1	<426..454	CDD:282609
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	477..530
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910