DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment not and Usp13

DIOPT Version :9

Sequence 1:	NP_001287106.1	Gene:	not / 40030	FlyBaseID:	FBgn0013717	Length:	496	Species:	Drosophila melanogaster
Sequence 2:	NP_001013042.1	Gene:	Usp13 / 72607	MGIID:	1919857	Length:	858	Species:	Mus musculus

Alignment Length:	702	Identity:	120/702 - (17%)
Similarity:	209/702 - (29%)	Gaps:	297/702 - (42%)

- Green bases have known domain annotations that are detailed below.

  Fly    31 CVNRDARERKAIHCNCFE----CGSYGIQLYACLHCIYFGCRG--AHITSHLRSKKHNVALELSH 89
            |...|.||.  :..|..:    ||.:           :|...|  .|...|.|...:.:|::|
Mouse   209 CARCDLREN--LWLNLTDGSVLCGKW-----------FFDSSGGNGHALEHYRDMGYPLAVKL-- 258

  Fly    90 GTL-------YCYACRDFIYDARSREYAL-----------INRKLEAKDLQKSIGWVPWVPTTKE 136
            ||:       |.:.....:.|....::..           ....|...|::         |...|
Mouse   259 GTITPDGADVYSFQEEGPVSDPHLAKHLAHFGIDMLHTQGTENGLRDNDIK---------PRVSE 314

  Fly   137 TNLLLANARRRLVRPNQTIGLRGLLNLGATCFMNCIVQALV-----------HTPLLSDY----- 185
            ..::..:..:  ::|....|..||.|||.:|:::.::||:.           :.|.:.||
Mouse   315 WEVIQESGTK--LKPMYGPGYTGLKNLGNSCYLSSVMQAIFSIPEFQRAYVGNLPRIFDYSPLDP 377

  Fly   186 ---FMSDRHDCG---------------------SKSSHKCLVCEVS-RLFQEFYSGSRSPLSLHR 225
               |.:.....|                     .|..||.....:| |:|:.|.|.|....|.:|
Mouse   378 TQDFNTQMTKLGHGLLSGQYSKPPVKSELIEQVMKEEHKPQQNGISPRMFKAFVSKSHPEFSSNR 442

  Fly   226 LLHLIWNHAKHLAGYEQQDAHEFFIATLDVLHRH---------------------CVKAKAEHES 269
                            ||||.|||:..::::.|:                     |...|..:..
Mouse   443 ----------------QQDAQEFFLHLVNLVERNRIGSENPSDVFRFLVEERIQCCQTRKVRYTE 491

  Fly   270 KSN-----SSGSGSGTNSSNSSSSHCY---GQCN----------------CI--------IDQIF 302
            :.:     .....:.||.....:....   .:.|                |:        :|..:
Mouse   492 RVDYLMQLPVAMEAATNKDELITYELMRREAEANRRPLPELVRAKIPFSACLQAFAEPDNVDDFW 556

  Fly   303 TGMLQSDVVCQACNGVST-----------------TYDPFW-----DISLDLGE--TTTH---GG 340
            :..||:...     ||.|                 |:...|     |:|:|:.:  ..:|   .|
Mouse   557 SSALQAKSA-----GVKTSRFASFPEYLVVQIKKFTFGLDWVPRKFDVSIDMPDLLDISHLRARG 616

  Fly   341 VTP-----------------------KTLID---------------------C------------ 349
            :.|                       ..|||                     |
Mouse   617 LQPGEEELPDISPPIVIPDDSKDRLMNQLIDPSDIDESSVMQLAEMGFPLEACRKAVYFTGNTGA 681

  Fly   350 ----------LERYTRAEHL------GSAAKIKCSTCKSYQESTKQFSLRTLPSVVSFH------ 392
                      :|....||.|      |:.|.:..:|....|...:..::.|   .:.|.
Mouse   682 EVAFNWIIVHMEEPDFAEPLAIPGYGGAGASVFGATGLDNQPPEEIVAIIT---SMGFQRNQAVQ 743

  Fly   393 -LKRFEHSALIDRK---ISSFIQFPVEFDMTPFMSEKKNAY--------------GDFRFSLYAV 439
             |:...|:  ::|.   |.|..:|..:.|....|....||.              |...:.|:|.
Mouse   744 ALQATNHN--LERALDWIFSHPEFEEDSDFVIEMENNANANIVSEAKPEGPRVKDGSGMYELFAF 806

  Fly   440 VNHVGTID-TGHYTAYVRHQKDTWVKCDDHVITMASLKQVLDSEGYLLFYHK 490
            ::|:||.. :|||..::: ::..||..:||.: .||.:...|. ||:.||.:
Mouse   807 ISHMGTSTMSGHYVCHIK-KEGRWVIYNDHKV-CASERPPKDL-GYMYFYRR 855

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
not	NP_001287106.1	zf-UBP	46..103	CDD:307999	12/69 (17%)
not	NP_001287106.1	Peptidase_C19D	158..489	CDD:239125	95/548 (17%)
Usp13	NP_001013042.1	UBP14	28..856	CDD:227532	120/702 (17%)
		zf-UBP	209..282	CDD:280334	18/87 (21%)
		Peptidase_C19B	335..854	CDD:239123	95/547 (17%)
		UBA1_UBP13	650..698	CDD:270567	2/47 (4%)
		UBA2_UBP5	723..764	CDD:270569	7/45 (16%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910