DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment not and usp22

DIOPT Version :9

Sequence 1:	NP_001287106.1	Gene:	not / 40030	FlyBaseID:	FBgn0013717	Length:	496	Species:	Drosophila melanogaster
Sequence 2:	XP_021335834.1	Gene:	usp22 / 692275	ZFINID:	ZDB-GENE-060512-211	Length:	507	Species:	Danio rerio

Alignment Length:	529	Identity:	277/529 - (52%)
Similarity:	347/529 - (65%)	Gaps:	55/529 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MSETGCRHYQSYVKEHSYDTFRVIDAYFAACVNRDARERKAIHCNCFECGSYGIQLYACLHCIYF 65
            ||..||.|...:..::.....|||...|....:.:.|:|||..|.|..||::..:|::||||::|
Zfish     1 MSPAGCSHVNGFKVDNWKQNLRVIYQCFVWSGSAETRKRKAKSCICHMCGAHLNRLHSCLHCVFF 65

  Fly    66 GC-RGAHITSHLRSKKHNVALELSHGTLYCYACRDFIYDARSREYALINRKLEAKDLQKSIG--W 127
            || ...||..|.::|:||:|::|.:|.:||:.|:|:||| :..|......:.:|..|| .||  :
Zfish    66 GCFSKKHIHEHAKNKRHNLAIDLLYGGIYCFVCQDYIYD-KDMEQIAKEEQRKAWKLQ-GIGEKY 128

  Fly   128 VPWVPTTKETNLLLANARRRLVRPNQTIGLRGLLNLGATCFMNCIVQALVHTPLLSDYFMSDRHD 192
            ..|.||.:|..||..|.:||.:..|.|||||||:|||.|||||||||||.|||||.|:|:||||.
Zfish   129 SMWEPTKRELELLRHNPKRRKITANCTIGLRGLINLGNTCFMNCIVQALTHTPLLRDFFLSDRHK 193

  Fly   193 CGSKSSHKCLVCEVSRLFQEFYSGSRSPLSLHRLLHLIWNHAKHLAGYEQQDAHEFFIATLDVLH 257
            | ...|:.|||||:|:||||||||.|||....|||||:|.||:|||||||||||||.||.|||||
Zfish   194 C-EMQSNSCLVCEMSQLFQEFYSGHRSPHIPFRLLHLVWTHARHLAGYEQQDAHEFLIAALDVLH 257

  Fly   258 RHCVKAKAEHESKSNSSGSGSGTNSSNSSSSHCYGQCNCIIDQIFTGMLQSDVVCQACNGVSTTY 322
            |||             .|..:|..::|.:      .|||||||||||.|||||.||.|:|||||.
Zfish   258 RHC-------------KGDDNGKKANNPN------HCNCIIDQIFTGGLQSDVTCQVCHGVSTTI 303

  Fly   323 DPFWDISLDL-GETTTHGGVTP----------------KTLIDCLERYTRAEHLGSAAKIKCSTC 370
            |||||||||| |.:|....::|                .||.|||.|:||.|||||:||||||.|
Zfish   304 DPFWDISLDLPGSSTPFWPLSPGSDGSVVNGDSHPSGATTLTDCLRRFTRPEHLGSSAKIKCSGC 368

  Fly   371 KSYQESTKQFSLRTLPSVVSFHLKRFEHSALIDRKISSFIQFPVEFDMTPFMSEKKNA------- 428
            .||||||||.:::.||.|..||||||||||.:.|||::::.||:|.||||||:..|.:
Zfish   369 HSYQESTKQLTMKRLPIVACFHLKRFEHSAKLRRKITTYVSFPLELDMTPFMASSKESRMNGQYQ 433

  Fly   429 ------YGDFRFSLYAVVNHVGTIDTGHYTAYVRHQKDTWVKCDDHVITMASLKQVLDSEGYLLF 487
                  ..|.::||:|||||.||:::||||.::|..||.|.||||.:||.||:|.||||||||||
Zfish   434 QPVDSLNNDNKYSLFAVVNHQGTLESGHYTTFIRQHKDQWFKCDDAIITKASIKDVLDSEGYLLF 498

  Fly   488 YHKNVLEYE 496
            |||..||||
Zfish   499 YHKQFLEYE 507

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
not	NP_001287106.1	zf-UBP	46..103	CDD:307999	25/57 (44%)
not	NP_001287106.1	Peptidase_C19D	158..489	CDD:239125	209/360 (58%)
usp22	XP_021335834.1	zf-UBP	46..106	CDD:307999	27/60 (45%)
usp22	XP_021335834.1	Peptidase_C19D	159..500	CDD:239125	209/360 (58%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170595798
Domainoid	1	1.000	411	1.000	Domainoid score	I650
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H52664
Inparanoid	1	1.050	535	1.000	Inparanoid score	I1164
OMA	1	1.010	-	-		QHG59954
OrthoDB	1	1.010	-	-		D200191at33208
OrthoFinder	1	1.000	-	-		FOG0002382
OrthoInspector	1	1.000	-	-		oto40605
orthoMCL	1	0.900	-	-		OOG6_102914
Panther	1	1.100	-	-	LDO	PTHR21646
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1575
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	14	13.870