Protein Alignment not and usp8

DIOPT Version :10

• Sequence 1: NP_001401041.1
• Gene: not / 40030
• FlyBaseID: FBgn0013717
• Length: 703
• Species: Drosophila melanogaster
• Sequence 2: XP_009291628.1
• Gene: usp8 / 565434
• ZFINID: ZDB-GENE-030131-1949
• Length: 1067
• Species: Danio rerio
• Alignment Length: 628
• Identity: 148/628 - (23%)
• Similarity: 254/628 - (40%)
• Gaps: 106/628 - (16%)

  Fly   127 TTNAGRFITADLIKTVNSDKQRDRVAKGHRDAKNPLDATKHLRLSDCLRTVQKLAIEL------- 184
            ||:..|.::|:....:..| ..|.:.|..|:.:....|.:..:|.|..:..:||..:.
Zfish   484 TTDPSRALSAEQRWEIQKD-TLDLMEKAKREQEQRRRAQEQEKLEDKQQDRRKLERQTAEEEDLK 547

  Fly   185 ESADAGSDASAQANASADASSAVMSETGCRHY---QSYVKEHSYDTFRVIDA------------- 233
            |::........|.:..|||....||......:   :...:.||.:..|.:..
Zfish   548 ETSPEDKSRKTQKDTPADAPMKSMSLDSPAQFNTREPLTRAHSEEMGRTVPGLPDGWMKFLDTVT 612

  Fly   234 ----YFAACVNRDARERKAIHCNCFECGSYGIQLYACLHCIYFGCRGAHITSHLRSKKHNVALEL 294
                |:.:..||                   :.||.           ..:::.....||....:.
Zfish   613 GTYRYYHSPTNR-------------------VHLYP-----------PEVSTPQTPAKHTPPAQP 647

  Fly   295 SHGT-LYCYACRDFIYDARSREYALINRKLEAKDLQKSI--------GWVPWVPTTKETNLLLAN 350
            :..| ......||     |.||.:.:.|...:.|:.:.:        ..||.:  .:|...|.|:
Zfish   648 AADTETEKQRQRD-----REREQSKLKRSYSSPDISQELSAETRQRPAAVPSI--NRENKPLAAS 705

  Fly   351 --ARRRLVRP--------NQTIG-----LRGLLNLGATCFMNCIVQALVHTPLLSDYF----MSD 396
              |:..:.||        |...|     |.||.|||.||:||.|:|.|.:|..::|||    ..|
Zfish   706 TYAKVEITRPSAAKIRNLNPVFGGQGPLLTGLRNLGNTCYMNSILQCLCNTVAMADYFNRNYYQD 770

  Fly   397 RHDCGSKSSHKCLVC-EVSRLFQEFYSGSRSPLSLHRLLHLIWNHAKHLAGYEQQDAHEFFIATL 460
            ..:..:...||..|. |.|.:.:..:.|....:|.......|.......:.||.||:.|..:..:
Zfish   771 DINRANILGHKGEVAEEFSVVMKALWLGQYKMISPLDFKGTICKINSRFSSYEHQDSQELLLFLM 835

  Fly   461 DVLHRHCVKAKAEHESKSNSSGSGSGTNSSNSSSSHCYGQCN-CIIDQIFTGMLQSDVVCQACNG 524
            |.||....||......|..........::::.:.|. :.|.| .||..:|.|..:|.|.|.:|..
Zfish   836 DGLHEDLNKADKRRGYKEEEIEHLDDVSAADLAWSK-HKQLNESIIVALFQGQFKSTVQCMSCQH 899

  Fly   525 VSTTYDPFWDISLDLGETTTHGGVTPKTLIDCLERYTRAEHLGSAAKIKCSTCKSYQESTKQFSL 589
            .|.|::.|..::|::..:      :..:|.|||:.:.:.|.|....:..|..||:::::.|:..:
Zfish   900 KSRTFETFMYLTLEMTAS------SKCSLQDCLKLFHKEERLTDGNRFYCRHCKTHRDAIKRMQI 958

  Fly   590 RTLPSVVSFHLKRFEHSALIDRKISSFIQFPVE-FDMTPFMSEKKNAYGDFRFSLYAVVNHVGTI 653
            ..||.::..|||||::......|:.:.:.||:: .|::.::...||...  :::||||.||.|.:
Zfish   959 WKLPPILLVHLKRFKYEGRWREKLQTLVDFPLDNLDLSQYVIGPKNNLK--KYNLYAVSNHYGGM 1021

  Fly   654 DTGHYTAYVRH-QKDTWVKCDDHVITMASLKQVLDSEGYLLFY 695
            |.||||||.:: .|..|.|.|||.::..|...|.....|:.||
Zfish  1022 DGGHYTAYCKNPMKQRWFKFDDHEVSEISSSTVRSPAAYIFFY 1064

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
not	NP_001401041.1	zf-UBP	253..310	CDD:460464	7/57 (12%)
		Peptidase_C19D	365..696	CDD:239125	99/339 (29%)
usp8	XP_009291628.1	USP8_dimer	8..116	CDD:462647
		RHOD	192..301	CDD:444705
		Atrophin-1	<306..>664	CDD:460830	34/215 (16%)
		UCH	735..1064	CDD:425685	97/337 (29%)