DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment not and usp21

DIOPT Version :9

Sequence 1:	NP_001287106.1	Gene:	not / 40030	FlyBaseID:	FBgn0013717	Length:	496	Species:	Drosophila melanogaster
Sequence 2:	XP_005162186.1	Gene:	usp21 / 563546	ZFINID:	ZDB-GENE-100210-3	Length:	405	Species:	Danio rerio

Alignment Length:	368	Identity:	110/368 - (29%)
Similarity:	172/368 - (46%)	Gaps:	36/368 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly   139 LLLANARRRLVRPNQTIGLRGLLNLGATCFMNCIVQALVHTPLLSDY-----FMSDRHDCGSKSS 198
            ||:.:..|.|...|..:|||   |:|.|||:|.|||.|.||..|.||     ::.|:|    .:.
Zfish    46 LLVTDKERELQLGNGQVGLR---NVGNTCFLNAIVQCLSHTRSLRDYCLMRAYVQDKH----SNQ 103

  Fly   199 HKCLVCEVSRLFQEFY--SGSRSPLSLHRLLHLIWNHAKHLAGYEQQDAHEFFIATLDVLH---- 257
            ...|:.|.|::....:  ....:.::..:...:......:.:||.||||.||....||.||
Zfish   104 EPVLMDEFSKVLAGLWECDAGETTVNPGKFYRVFKESVPYFSGYSQQDAQEFLRFLLDRLHTEIN 168

  Fly   258 RHCVKAKAEHESKSNSSGSGSGTNSSNSSSSHCYGQCNC------IIDQIFTGMLQSDVVCQACN 316
            |...|..|..|.|..:.     |....|..:....|.:.      |:| :|:|.|:|.:.|..|:
Zfish   169 RRPSKRPAVIERKEPAY-----TRFRISEEAFAMWQRHLDRDDSKIVD-LFSGQLRSSLHCSVCS 227

  Fly   317 GVSTTYDPFWDISLDLGETTTHGGVTPKTLIDCLERYTRAEHLGSAAKIKCSTCKSYQESTKQFS 381
            ..|.|:|.|.|:||.:.:..:..| ...||.:||:.:::.|.|.......|..|....||||:.:
Zfish   228 HYSNTFDVFCDLSLPIPKQKSDYG-RAVTLRECLDLFSQEEKLDKENSPMCERCNRRTESTKRLT 291

  Fly   382 LRTLPSVVSFHLKRFEHSALIDRKISSFIQFPV-EFDMTPFMSEKKNAYGDFRFSLYAVVNHVGT 445
            ::..|.|:..||.||..|.....|.:..:.||: ..|:..|....   .|...:.||||.||.||
Zfish   292 IQRFPRVLVIHLNRFAMSRFSISKSTVPVSFPLTALDLGLFGPVD---CGPVLYDLYAVCNHSGT 353

  Fly   446 IDTGHYTAYVRHQKDTWVKCDDHVITMASLKQVLDSEGYLLFY 488
            ::.|||||..| :::.|...:|..:...|.:::..::.|:|||
Zfish   354 VNMGHYTAACR-EEEGWCFYNDSCVDAISEEKLQSNQAYVLFY 395

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
not	NP_001287106.1	zf-UBP	46..103	CDD:307999
not	NP_001287106.1	Peptidase_C19D	158..489	CDD:239125	103/349 (30%)
usp21	XP_005162186.1	UCH	62..395	CDD:278850	103/350 (29%)
usp21	XP_005162186.1	Peptidase_C19R	63..396	CDD:239139	105/351 (30%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910