DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment not and usp34

DIOPT Version :9

Sequence 1:	NP_001287106.1	Gene:	not / 40030	FlyBaseID:	FBgn0013717	Length:	496	Species:	Drosophila melanogaster
Sequence 2:	XP_009292973.3	Gene:	usp34 / 562779	ZFINID:	ZDB-GENE-100210-6	Length:	3624	Species:	Danio rerio

Alignment Length:	598	Identity:	113/598 - (18%)
Similarity:	203/598 - (33%)	Gaps:	181/598 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MSETGCRHY---------QSYVKEHSYDTFRVIDA---YFAACVNRDARERKAI----------- 42
            |..:||:.|         ..:||:.|..|...:||   :.|.|:    |.|:.:
Zfish  1783 MFRSGCKEYFWLLCKLIDNIHVKDASQTTLLDLDALARHLADCI----RSREILDQQDGAIEDDG 1843

  Fly    43 -------------HCNCFECGSYGIQLYACLHCIYF-----------GCRGAHITSHLRSKKHNV 83
                         |...|:....|.:.....:.:.|           .|:    :...|:..:::
Zfish  1844 LTGLLRLATSVLKHKPPFKFSREGQEFLRDTYDLLFLLPSLKDRQQPKCK----SPAARAAAYDL 1904

  Fly    84 ALELSHGTLYCYACRDFIYDARSREYALINRKLEAKDLQKS---IGWVPWVPTTKETNLLLANAR 145
            .:|:..|::              ..|.|::..:.::.:|.|   ..|..|....       ..|.
Zfish  1905 LVEVVKGSV--------------ENYRLLHNWVMSQHMQASHAPYKWDYWPHDD-------VRAE 1948

  Fly   146 RRLVRPNQTIGLRGLLNLGATCFMNCIVQALVHTPLLSDYFMSDRHDCGSKSSHKCLVCEVSRLF 210
            .|.|         ||.||||||::...:|.|...|.......:.::....|  ||..:.|:.::|
Zfish  1949 CRFV---------GLTNLGATCYLASTIQQLYMIPEARQAVFTAKYSEDIK--HKTTLLELQKMF 2002

  Fly   211 QEFYSGSRSPLSLHRLLHLIWNHAKHLAGYEQQDAHEFFIATLDVLHRHCVKAKAEHESKSNSSG 275
            .......|...:............:.|...||:|..|||   .|::      .|.|..|:...:
Zfish  2003 TYLMESERKAYNPRPFCKTYTMDKQPLNTGEQKDMTEFF---TDLI------TKIEEMSQDLKN- 2057

  Fly   276 SGSGTNSSNSSSSHCYGQCNCIIDQIFTGMLQSDVVCQACNGVSTTYDPFWDISLDLGETTTHGG 340
                                 .:..:|.|::.::||...|:.||.|.:.|:.:...:.:.
Zfish  2058 ---------------------TVKTLFGGVITNNVVSLDCDHVSQTAEEFYTVRCQVADM----- 2096

  Fly   341 VTPKTLIDCLERYTRAEHLGSAAKIKCSTCKSYQESTKQFSLRTLPSVVSFHLKR--FEHSALID 403
               |.:.:.|:..|..:.|.......||.|.....:.|:...:.||.::||:..|  |....::.
Zfish  2097 ---KNIYESLDEVTIKDTLEGDNMYTCSQCGKKVRAEKRACFKKLPRILSFNTMRYTFNMVTMMK 2158

  Fly   404 RKISSFIQFPVEFDMTPFMSEKKNAYGD----------------FRFSLYAVVNHVGTIDTGHYT 452
            .|:::...||:..||||:..:...|.||                :.:.|..|..|.||.|.|||.
Zfish  2159 EKVNTHFSFPLRLDMTPYTEDFLMAKGDRKEGFRDDSDAKVAESYEYDLIGVTVHTGTADGGHYY 2223

  Fly   453 AYVR-------HQKDTWV-----------------KCDDHVITMASLKQVLDS----------EG 483
            :::|       ::.:.|.                 :|....:|..:...|.|.          ..
Zfish  2224 SFIRDIINPHAYRNNKWYLFNDAEVKPFDSAQLASECFGGEMTTKTYDSVTDKFMDFSFEKTHSA 2288

  Fly   484 YLLFYHKNVLEYE 496
            |:|||.:..:|.|
Zfish  2289 YMLFYKRVEVEEE 2301

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
not	NP_001287106.1	zf-UBP	46..103	CDD:307999	7/67 (10%)
not	NP_001287106.1	Peptidase_C19D	158..489	CDD:239125	79/382 (21%)
usp34	XP_009292973.3	peptidase_C19C	1950..2297	CDD:239124	82/396 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910