DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment not and usp30

DIOPT Version :9

Sequence 1:	NP_001287106.1	Gene:	not / 40030	FlyBaseID:	FBgn0013717	Length:	496	Species:	Drosophila melanogaster
Sequence 2:	XP_005165213.1	Gene:	usp30 / 559099	ZFINID:	ZDB-GENE-060526-335	Length:	501	Species:	Danio rerio

Alignment Length:	476	Identity:	112/476 - (23%)
Similarity:	173/476 - (36%)	Gaps:	142/476 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly   127 WVPWVPTTKETNLLLANARRRLVRPNQTIGLRGLLNLGATCFMNCIVQALVHTP----LLSDYFM 187
            :|.|.|.:.          ||..|...   :.||||||.|||||.::|.|...|    .|.|:..
Zfish    46 YVLWGPISD----------RRKKRKGM---VPGLLNLGNTCFMNSLLQGLAACPSFIRWLEDFTS 97

  Fly   188 SDRHDCGSKSSHKCLVCEVSRLFQEFYS---GSRSPLSLHRLLHLIWNHAKHLAGYEQQDAHEFF 249
            .:..|.........|...:.:|.:...|   |....|....||..:..:..|::.:|:|||||.|
Zfish    98 QNSADRERTERETQLSRSLMQLLKALSSHDPGEDDVLDAGGLLEALRLYRWHISSFEEQDAHELF 162

  Fly   250 ---IATLD--------VLH---RHCVKAKAEHESKSNSSGSGSGTNSSNS--SSSHCYGQCNCII 298
               .::|:        |.|   ...::...|.:.|:.|..||...:...|  .:.|
Zfish   163 HVLTSSLEEEQERQPRVAHLFDMQTLEKSVESKEKNISCRSGGPLHPIPSLWRTRH--------- 218

  Fly   299 DQIFTGMLQSDVVCQACNGVSTT-YDPFWDISLDLGETTTHGGVTPKTLIDCLERYTRAEHLGSA 362
              .|.|.|.|.:.|:.|...|.. ||.|..:||.:  .:...| .|.||..||:.:..:|   :.
Zfish   219 --PFHGRLTSYMACKRCEQQSPVHYDSFDSLSLSI--PSIQWG-RPVTLDQCLQHFISSE---TI 275

  Fly   363 AKIKCSTCKSYQ----------ES-----TKQFSLRTLPSVVSFHLK------------------ 394
            .:::|..|...|          ||     .||..|..||..:..||:
Zfish   276 KEVECENCTKQQAGELVNGEVLESQRTTFVKQLKLGKLPQCLCIHLQRLTWSKEGSPIKRQEHVQ 340

  Fly   395 --------RFEHSALI-------------------DRKISSFIQ--------------FPVEFDM 418
                    |::|.:..                   |:.|::.:.              ||..|..
Zfish   341 FTEYLSLDRYKHCSAAQSQQKTSRTNKAKASADPKDKAIANGVDSEHCNNNKPQSNGTFPSVFLH 405

  Fly   419 TPFMSEKKN-----AYGDFRFSLYAVVNHVGTIDTGHYTAYVRHQ---------KDTWVKCDDHV 469
            :|.:|.:.|     :..::.|.|.||:.|.|.:.:||:..|.|..         ...|:...|..
Zfish   406 SPGLSSQLNLTYDYSTSEYLFRLTAVLVHHGDMHSGHFITYRRCPAAPRGTSPFSSQWLWVSDDS 470

  Fly   470 ITMASLKQVLDSEGYLLFYHK 490
            :..|||::||.|..|||||.:
Zfish   471 VRKASLQEVLSSSAYLLFYER 491

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
not	NP_001287106.1	zf-UBP	46..103	CDD:307999
not	NP_001287106.1	Peptidase_C19D	158..489	CDD:239125	105/442 (24%)
usp30	XP_005165213.1	Peptidase_C19	57..>171	CDD:271592	34/116 (29%)
		Peptidase_C19F	65..490	CDD:239127	105/441 (24%)
		UCH	65..489	CDD:278850	104/440 (24%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1867
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.810