DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment not and usp13

DIOPT Version :9

Sequence 1:	NP_001287106.1	Gene:	not / 40030	FlyBaseID:	FBgn0013717	Length:	496	Species:	Drosophila melanogaster
Sequence 2:	NP_001091856.1	Gene:	usp13 / 558011	ZFINID:	ZDB-GENE-080724-7	Length:	860	Species:	Danio rerio

Alignment Length:	449	Identity:	81/449 - (18%)
Similarity:	145/449 - (32%)	Gaps:	145/449 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly    49 CGSYGIQLYACLHCIYFGCRG-AHITSHLRSKKHNVALELSHGT-----LYCYACRDFIYDARSR 107
            ||.:          .:.|..| .|...|.|.....:|::|:..|     :|.:...:.:.|....
Zfish   212 CGKW----------FFDGSGGNGHALEHYRESNFPLAVKLNTITPDGADIYSFDEEEAVLDPHIS 266

  Fly   108 EYALINRKLEAKDLQKS--------------IGWVPWVPTTKETNLLLANARRRLVRPNQTIGLR 158
            |: |::..::...:|::              ..|    ...:|..|.|        :|....|..
Zfish   267 EH-LLHFGIDMLQMQRTENGHHTDNHVQPRISDW----EVIQEAGLKL--------KPVYGSGYT 318

  Fly   159 GLLNLGATCFMNCIVQALVHTP-----------LLSDYF----MSDRHDCGSKSSHKCLVCEVSR 208
            |:.|||.:|:::..:|.|...|           .:.||.    ..|.:...:|..|..|..:.|:
Zfish   319 GIKNLGNSCYLSTTMQVLFSIPEFQRAYAGNLQRIFDYSPLDPTQDFNTQMAKLGHGLLSGQYSK 383

  Fly   209 -----------LFQEFYSGSRSPLSLHRLLHLIWNHAKHLAGYEQQDAHEFFIATLDVLHRHCVK 262
                       :.:|.....:..:|......|:.......:...|||||||.:..::::.|
Zfish   384 PPMKSELIEQVMKEEHKQQQQRGISPKMFKALVSKGHPEFSSNRQQDAHEFLLHLINLVER---- 444

  Fly   263 AKAEHESKSNSSGSGSGTNSSNSSSSHCYGQCNCIIDQIFTGMLQSDVVCQACNGVSTTYDPFWD 327
                     |:||      |.|.|             .:|..:::....|  |......|....|
Zfish   445 ---------NNSG------SENPS-------------DVFRFIVEERTQC--CQSQKVRYTQRVD 479

  Fly   328 ISLDL----------GETTTHGGV------------------TPKTLIDCLERYTRAEHL----G 360
            ..:.|          .|...:.|.                  .|.|.  ||:.:|..|::    .
Zfish   480 YLMQLPVPLEAASNREELIAYEGKRKEAEENMRPLPEVVRARVPFTA--CLQAFTEPENVPDFWS 542

  Fly   361 SAAKIKCSTCKSYQESTKQFSLRTLPSVVSFHLKRFEHSA-LIDRKISSFIQFPVEFDM 418
            ||.:.|.:..|     |.:|:  |.|..:...||:|.... .:.:|:...:..|...|:
Zfish   543 SALQAKSAGVK-----TSRFA--TFPEYMIVQLKKFTFGVDWVPKKLDMSVDVPDFLDL 594

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
not	NP_001287106.1	zf-UBP	46..103	CDD:307999	11/59 (19%)
not	NP_001287106.1	Peptidase_C19D	158..489	CDD:239125	60/320 (19%)
usp13	NP_001091856.1	UBP14	13..857	CDD:227532	81/449 (18%)
		zf-UBP	192..264	CDD:280334	12/61 (20%)
		Peptidase_C19B	319..855	CDD:239123	60/319 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	611..636
		UBA1_UBP13	635..683	CDD:270567
		UBA2_UBP5	711..752	CDD:270569
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	755..795
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910