DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment not and usp32

DIOPT Version :9

Sequence 1:NP_001287106.1 Gene:not / 40030 FlyBaseID:FBgn0013717 Length:496 Species:Drosophila melanogaster
Sequence 2:XP_686236.6 Gene:usp32 / 557981 ZFINID:ZDB-GENE-100210-5 Length:1585 Species:Danio rerio


Alignment Length:504 Identity:123/504 - (24%)
Similarity:198/504 - (39%) Gaps:130/504 - (25%)


- Green bases have known domain annotations that are detailed below.


  Fly    64 YFGC-------RGAH--ITSHLRSKKHNVALELSHGTLYCYACRDFIYDARS----REYALINRK 115
            |.||       :..|  ::..||.|:.::.|.|.:...|.....|..:...|    .|..|:   
Zfish   638 YTGCFSRMCTIKDIHEYLSQRLRIKEEDMRLWLYNSENYLTLLDDEDHTLESLKIPDEQHLV--- 699

  Fly   116 LEAKDLQKSIGWVPWVPTTKETNLLLANARR--RLVRPNQTIGLRGLLNLGATCFMNCIVQALVH 178
            :|.::  |.:.|       .|....:||:.:  |...|.:. |..||.|||.|||||..:|.:.:
Zfish   700 IEVRN--KDMSW-------PEEMSFIANSSKIDRHKVPTEK-GATGLSNLGNTCFMNSSIQCVSN 754

  Fly   179 TPLLSDYFMSDRH--------DCGSKSSH--KCLVCEVSRLFQEFYSGSRSPLSLHRLLHLIWNH 233
            |..|::||:|.||        ..|.: .|  ||    ...|.||.:||::..::..:|...|..:
Zfish   755 TKPLTEYFISGRHLYELNRTNPIGMR-GHMAKC----YGDLVQELWSGTQKNVAPLKLRWTIAKY 814

  Fly   234 AKHLAGYEQQDAHEFFIATLDVLHRHCVKAKAEHESK----SNSSGSGSGTNSSNSSSSHCYGQC 294
            |....|::|||:.|.....||.||....:.   ||..    .:|.|......::.:..:|.....
Zfish   815 APRFNGFQQQDSQELLAFLLDGLHEDLNRV---HEKPYVELKDSDGRPDHEVATEAWENHLRRNR 876

  Fly   295 NCIIDQIFTGMLQSDVVCQACNGVSTTYDPFWDISLDLG-ETTTH--------GGVTPKTLIDCL 350
            :.::| :|.|.|:|.|.|:.|..:|..:|||..:||.|. :::.|        .|.||       
Zfish   877 SIVVD-LFHGQLRSQVKCKTCGHISARFDPFNFLSLPLPMDSSMHLEITVIKLDGSTP------- 933

  Fly   351 ERYTRAEHLGSAAKIKCSTCKSYQESTKQF----SLR----TLPSVVSFHLKRFE-HSALIDRKI 406
            .||          .::.:..:.|....||.    ||:    .|..|.:.::|.|. .:..:...:
Zfish   934 VRY----------GLRLNMDEKYMGLKKQLSELCSLKPEQILLAEVHTSNIKNFPLDNQKVRHSV 988

  Fly   407 SSFI---QFPVEFDMT----PFMSEKKN-AYGDFRFSLYAVVNHV---GTIDTGHYTAYVRHQKD 460
            :.|:   :.||....|    |..:||.. |.|.      |..||:   |.|..|        ...
Zfish   989 NGFLCAFEIPVPGSPTSVTSPVQTEKPPIANGT------AGNNHIGKSGLIPNG--------MPS 1039

  Fly   461 TWVKC-----------DDHVITMASLKQVLDSE--GYLLFYHKNVLEYE 496
            |.|.|           :.|.:      .|.||.  ||::..|:.::..|
Zfish  1040 TVVPCTLEKPLANGIPNGHAV------PVQDSPFIGYIIAMHRKMMRTE 1082

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
notNP_001287106.1 zf-UBP 46..103 CDD:307999 11/47 (23%)
Peptidase_C19D 158..489 CDD:239125 98/386 (25%)
usp32XP_686236.6 EF-hand_7 236..293 CDD:290234
EFh 237..293 CDD:238008
EF-hand_7 270..342 CDD:290234
EFh 270..338 CDD:298682
DUSP <519..586 CDD:283896
UBP12 521..1546 CDD:227847 123/504 (24%)
Ubiquitin_3 623..710 CDD:291502 17/83 (20%)
Peptidase_C19 733..>918 CDD:271592 59/193 (31%)
Peptidase_C19 <1220..1546 CDD:271592
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R1591
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
11.030

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