DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment not and Usp2

DIOPT Version :9

Sequence 1:	NP_001287106.1	Gene:	not / 40030	FlyBaseID:	FBgn0013717	Length:	496	Species:	Drosophila melanogaster
Sequence 2:	NP_058088.2	Gene:	Usp2 / 53376	MGIID:	1858178	Length:	619	Species:	Mus musculus

Alignment Length:	348	Identity:	121/348 - (34%)
Similarity:	170/348 - (48%)	Gaps:	31/348 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly   156 GLRGLLNLGATCFMNCIVQALVHTPLLSDYFMSDRH--DCG-SKSSHKCLVCEVSRLFQEFYSGS 217
            ||.||.|||.|||||.|:|.|.:|..|.||.:...:  |.| :.|:|..|:.|.::|.|..::.|
Mouse   279 GLAGLRNLGNTCFMNSILQCLSNTRELRDYCLQRLYMRDLGHTSSAHTALMEEFAKLIQTIWTSS 343

  Fly   218 -RSPLSLHRLLHLIWNHAKHLAGYEQQDAHEFFIATLDVLH----RHCVKAKAEHESKSNSSGSG 277
             ...:|.......|..:|....||.||||.||....||.||    |...:.||..|:..:.....
Mouse   344 PNDVVSPSEFKTQIQRYAPRFMGYNQQDAQEFLRFLLDGLHNEVNRVAARPKASPETLDHLPDEE 408

  Fly   278 SGTNS-----SNSSSSHCYGQCNCIIDQIFTGMLQSDVVCQACNGVSTTYDPFWDISLDLGETTT 337
            .|...     ....|.         |..:|.|.|:|.:.|..|...||.:|||||:||.:.:.
Mouse   409 KGRQMWRKYLEREDSR---------IGDLFVGQLKSSLTCTDCGYCSTVFDPFWDLSLPIAKR-- 462

  Fly   338 HGGVTPKTLIDCLERYTRAEHLGSAAKIKCSTCKSYQESTKQFSLRTLPSVVSFHLKRFEHSALI 402
              |....||:||:..:|:.:.|....|..|..|::.:...|:||::..|.::..|||||..|.:.
Mouse   463 --GYPEVTLMDCMRLFTKEDILDGDEKPTCCRCRARKRCIKKFSVQRFPKILVLHLKRFSESRIR 525

  Fly   403 DRKISSFIQFPV-EFDMTPFMSEKKNAYGDFRFSLYAVVNHVGTIDTGHYTAYVRHQ-KDTWVKC 465
            ..|:::|:.||: :.|:..|.||..|   ...::||||.||.||...||||||.|.. ...|...
Mouse   526 TSKLTTFVNFPLRDLDLREFASENTN---HAVYNLYAVSNHSGTTMGGHYTAYCRSPVTGEWHTF 587

  Fly   466 DDHVITMASLKQVLDSEGYLLFY 488
            :|..:|..|..||..|:.|||||
Mouse   588 NDSSVTPMSSSQVRTSDAYLLFY 610

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
not	NP_001287106.1	zf-UBP	46..103	CDD:307999
not	NP_001287106.1	Peptidase_C19D	158..489	CDD:239125	119/346 (34%)
Usp2	NP_058088.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..23
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	54..112
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	221..275
		UCH	281..610	CDD:395355	117/344 (34%)
		Necessary for interaction with MDM4. /evidence=ECO:0000250\|UniProtKB:O75604	417..517		32/112 (29%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1591
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.940