DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment not and usp2a

DIOPT Version :9

Sequence 1:	NP_001287106.1	Gene:	not / 40030	FlyBaseID:	FBgn0013717	Length:	496	Species:	Drosophila melanogaster
Sequence 2:	XP_005157570.1	Gene:	usp2a / 494031	ZFINID:	ZDB-GENE-041212-59	Length:	564	Species:	Danio rerio

Alignment Length:	345	Identity:	118/345 - (34%)
Similarity:	179/345 - (51%)	Gaps:	21/345 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly   156 GLRGLLNLGATCFMNCIVQALVHTPLLSDYFM--SDRHDCGSKS-SHKCLVCEVSRLFQEFYSGS 217
            ||.||.|||.|||||.|:|.|.:|..|.||.:  |.|.|..:.: :|..|:.|.::|.|..::.|
Zfish   228 GLVGLRNLGNTCFMNSILQCLSNTQSLRDYCLHNSHRRDLNNNNRTHTALMEEFAKLIQTMWTSS 292

  Fly   218 RS-PLSLHRLLHLIWNHAKHLAGYEQQDAHEFFIATLDVLH----RHCVKAKAEHESKSNSSGSG 277
            .| .:|.......|..:|....||.||||.||....||.||    |..|:.:...|...:.....
Zfish   293 SSEAVSPSEFKTQIQRYAPRFVGYNQQDAQEFLRFLLDGLHNEVNRVTVRPRGNTEDFDHLPDEE 357

  Fly   278 SGTNSSNSSSSHCYGQCNCIIDQIFTGMLQSDVVCQACNGVSTTYDPFWDISLDLGETTTHGGVT 342
            .|   ....|.:...:.:.|:| :|.|.|:|.:.|..|...||.:|||||:||.:.:.    |..
Zfish   358 KG---KKMWSKYLEREDSKIVD-LFVGQLKSSLTCSECGYCSTVFDPFWDLSLPIAKK----GYG 414

  Fly   343 PKTLIDCLERYTRAEHLGSAAKIKCSTCKSYQESTKQFSLRTLPSVVSFHLKRFEHSALIDRKIS 407
            ..:|:||:..:|:.:.|....|..|..||:.:..||:|:::..|.::..|||||..:.:...|:|
Zfish   415 EVSLMDCMRLFTKEDVLDGDEKPTCYRCKARRRCTKKFTVQKFPKILVLHLKRFSEARIRTSKLS 479

  Fly   408 SFIQFPV-EFDMTPFMSEKKNAYGDFRFSLYAVVNHVGTIDTGHYTAY-VRHQKDTWVKCDDHVI 470
            :|:.||: :.|:..|.|::.::   ..::||||.||.||...|||||| ...:...|...:|..:
Zfish   480 TFVNFPMKDLDLREFASDRSSS---AVYNLYAVSNHSGTTMGGHYTAYCCNPENGEWYTYNDSRV 541

  Fly   471 TMASLKQVLDSEGYLLFYHK 490
            |..|..||..|:.|:|||.:
Zfish   542 TPMSASQVRSSDAYVLFYER 561

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
not	NP_001287106.1	zf-UBP	46..103	CDD:307999
not	NP_001287106.1	Peptidase_C19D	158..489	CDD:239125	115/340 (34%)
usp2a	XP_005157570.1	UCH	230..559	CDD:306860	114/339 (34%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1591
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.940