DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment not and puf

DIOPT Version :9

Sequence 1:	NP_001287106.1	Gene:	not / 40030	FlyBaseID:	FBgn0013717	Length:	496	Species:	Drosophila melanogaster
Sequence 2:	NP_001262923.1	Gene:	puf / 42935	FlyBaseID:	FBgn0039214	Length:	3930	Species:	Drosophila melanogaster

Alignment Length:	511	Identity:	100/511 - (19%)
Similarity:	170/511 - (33%)	Gaps:	163/511 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly    67 CRGAHITSHLRSKKHNVALELSHGTLYCYACRDFIYDARSREYALINRKLEAKDLQKSIGWVPWV 131
            |:.|    ..|:..:::.:||      |..|        :..||.::.:|.|:.........||.
  Fly  1955 CKSA----SSRASAYDLLVEL------CRGC--------ATNYAYLHGRLLAQHKSGPKQPYPWD 2001

  Fly   132 PTTKETNLLLANARRRLVRPNQTIGLRGLLNLGATCFMNCIVQALVHTPLLSDYFMSDRHDCGSK 196
            ...::..             ....|..||.||||||:|...||.|...|......:  |....:.
  Fly  2002 YWPRDEG-------------RAECGYVGLTNLGATCYMASCVQHLYMMPQARAAVL--RVPPNAA 2051

  Fly   197 SSHKCLVCEVSRLFQEFYSGSR---SPLSLHRLLHLIWNHAKHLAGYEQQDAHEFFIATLDVLH- 257
            ..|...:.|:.|:|.......|   :|.|..|:..:  :|.....| ||:|..||||..:..|.
  Fly  2052 RKHGPTLLELQRMFAYLLESERKSYNPRSFCRVYQM--DHQPLNTG-EQKDMAEFFIDLVSKLED 2113

  Fly   258 -----RHCVKAKAEHESKSNSSGSGSGTNSSNSSSSHCYGQCNCIIDQIFTGMLQSDVVCQACNG 317
                 :|.||                                     ::|.|.|.::||...|..
  Fly  2114 MTPDLKHLVK-------------------------------------RLFCGSLSNNVVSLDCGH 2141

  Fly   318 VSTTYDPFWDISLDLGETTTHGGVTPKTLIDCLERYTRAEHLGSAAKIKCSTCKSYQESTKQFSL 382
            ||.|.:.|:.:...:.:.        :.|.:.|:..|..:.|.......||.|.....:.|:...
  Fly  2142 VSRTAEDFYTVRCQVADM--------RNLQESLDEVTVKDTLEGDNMYTCSQCGKKVRAEKRACF 2198

  Fly   383 RTLPSVVSFHLKR--FEHSALIDRKISSFIQFPVEFDMTPFM-----------------SEKKNA 428
            :.||.::.|:..|  |....::..|:::...||:..:|..::                 .||:.|
  Fly  2199 KKLPQILCFNTMRYTFNMVTMLKEKVNTHFSFPLRLNMCHYVEKTLMPQQYKEERERRQKEKEGA 2263

  Fly   429 YGD--------------------FRFSLYAVVNHVGTIDTGHYTAYVR-------HQKDTWVKCD 466
            .|.                    :.:.|..|..|.||.|.|||.::::       |..:.|...:
  Fly  2264 DGSGDGNDNEKAEATLDDDIEECYEYELVGVTVHTGTADGGHYYSFIKERTKTSYHTHERWFLFN 2328

  Fly   467 DHVITMASLKQV---------------------LD------SEGYLLFYHKNVLEY 495
            |..:......|:                     ||      :..|:|||.:.:.|:
  Fly  2329 DAEVKPFDPSQIAAECFGGEMTSKTYDSVTEKYLDFSFEKTNSAYMLFYERRLPEH 2384

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
not	NP_001287106.1	zf-UBP	46..103	CDD:307999	7/35 (20%)
not	NP_001287106.1	Peptidase_C19D	158..489	CDD:239125	84/412 (20%)
puf	NP_001262923.1	peptidase_C19C	2013..2382	CDD:239124	86/418 (21%)
		UCH	2014..2377	CDD:278850	83/412 (20%)
		DUF3517	2723..>2877	CDD:288853
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.910