DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment not and usp5

DIOPT Version :9

Sequence 1:	NP_001287106.1	Gene:	not / 40030	FlyBaseID:	FBgn0013717	Length:	496	Species:	Drosophila melanogaster
Sequence 2:	XP_005173534.1	Gene:	usp5 / 406618	ZFINID:	ZDB-GENE-040426-2584	Length:	853	Species:	Danio rerio

Alignment Length:	426	Identity:	80/426 - (18%)
Similarity:	142/426 - (33%)	Gaps:	119/426 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    64 YFGCRGAHITSHLRSKKHNVALELSHGTL-------YCYACRDFIYDARSREYALINRKLEAKDL 121
            ||...|.:..:.|..::....|.:..||:       |.|...|.:.|::..|: |.:..::...:
Zfish   221 YFDGSGGNNHALLYYQQTGYPLAVKLGTITPDGADVYSYDEDDMVLDSKLPEH-LSHFGIDMMTM 284

  Fly   122 QKSIGWVPWVPTTKETNLLLANARR-----------RLVRPNQTIGLRGLLNLGATCFMNCIVQA 175
            :|:        ....|.|.:|..:|           ..:||....||.|:.|||.:|::|.::|.
Zfish   285 EKT--------ERTMTELEIAVNQRVGEWEVIQESGTTLRPLWGPGLTGMKNLGNSCYLNSVMQV 341

  Fly   176 LVHTPLLSDYFMS------DRHDCGSKSSHKCLVCEVS-RLFQEFYS-----------------G 216
            |...|.....::|      |..........|..|.::. .|....||                 |
Zfish   342 LFTIPDFQTKYVSNIDKIFDEAPSDPTQDFKTQVAKLGYGLLSGEYSKPAPDPADEPNTSAEPRG 406

  Fly   217 SRSPLSLHRLLHLIWNHAKHLAGYEQQDAHEFFIATLDVLHRHCVKAKAEHESKSNSSGSGSGTN 281
            .:..::......|:.......:...||||.||.:..::::.|:|                .||.|
Zfish   407 DQVGIAPRMFKALVGRGHPEFSTNRQQDAQEFLLHFINMVERNC----------------RSGMN 455

  Fly   282 SSNSSSSHCYGQCNCIIDQIFTGMLQSDVVCQACNGV------------------STTYDPFWDI 328
            .|                :.|..:::..:|||.....                  :|..|...:.
Zfish   456 PS----------------EAFRFLVEEKIVCQQSQKAKYTQRVDYIVQLPVPMDQATNMDELQEA 504

  Fly   329 SLDLGETTTHGG---VTPKTLID---CLERYTRAEHL----GSAAKIKCSTCKSYQESTKQFSLR 383
            .....|..:.|.   |.|:..|.   ||...:..|.|    .||.:.|.:..|     |.:|:
Zfish   505 ERRREEAESSGAPPPVAPRAQIPFAACLAALSEPETLTDFWSSAVQAKTTATK-----TTRFA-- 562

  Fly   384 TLPSVVSFHLKRFEHSA-LIDRKISSFIQFPVEFDM 418
            :.|..:...:|:|.... .:.:|:...|..|...|:
Zfish   563 SFPDHLVIQIKKFTFGLDWVPKKLDVSIDVPETLDL 598

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
not	NP_001287106.1	zf-UBP	46..103	CDD:307999	10/45 (22%)
not	NP_001287106.1	Peptidase_C19D	158..489	CDD:239125	58/314 (18%)
usp5	XP_005173534.1	UBP14	24..850	CDD:227532	80/426 (19%)
		zf-UBP	197..270	CDD:280334	11/48 (23%)
		Peptidase_C19B	325..849	CDD:239123	58/313 (19%)
		UBA1_UBP5_like	654..697	CDD:270480
		UBA2_UBP5	720..761	CDD:270569
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910