DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment not and USP17L1

DIOPT Version :9

Sequence 1:	NP_001287106.1	Gene:	not / 40030	FlyBaseID:	FBgn0013717	Length:	496	Species:	Drosophila melanogaster
Sequence 2:	NP_001243802.1	Gene:	USP17L1 / 401447	HGNCID:	37182	Length:	530	Species:	Homo sapiens

Alignment Length:	375	Identity:	104/375 - (27%)
Similarity:	171/375 - (45%)	Gaps:	62/375 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly   132 PTTKETNLLLAN-----ARRRLVRPNQTIGLR-------GLLNLGATCFMNCIVQALVHTPLLSD 184
            |.:.||.:.|.:     ||:...|....:..|       ||.|:|.||:.|..:|.|.:|..|::
Human    42 PLSSETRVDLCDDLAPVARQLAPREKLPLSSRRPAAVGAGLQNMGNTCYENASLQCLTYTLPLAN 106

  Fly   185 YFMSDRHDCGSKSSHKCLVCEVSRLFQEFYSGSRSPLSLHRLLHLIWNHAKHLAGY---EQQDAH 246
            |.:|..|....:....|::|.:.         :....:||...|:|.......||:   :|:|.|
Human   107 YMLSREHSQTCQRPKCCMLCTMQ---------AHITWALHSPGHVIQPSQALAAGFHRGKQEDVH 162

  Fly   247 EFFIATLDVLHRHCVKA--KAEHESKSNSSGSGSGTNSSNSSSSHCYGQCNCIIDQIFTGMLQSD 309
            ||.:.|:|.:.:.|:..  :.:|..|..:                       :|.|||.|..:|.
Human   163 EFLMFTVDAMKKACLPGHKQVDHHCKDTT-----------------------LIHQIFGGCWRSQ 204

  Fly   310 VVCQACNGVSTTYDPFWDISLDLGETTTHGGVTPKTLIDCLERYTRAEHLGSAAKIKCSTCKSYQ 374
            :.|..|:|:|.|:||:.||:||:        ...:::...||:..:.|.|.......|..|....
Human   205 IKCLHCHGISDTFDPYLDIALDI--------QAAQSVKQALEQLVKPEELNGENAYHCGLCLQRA 261

  Fly   375 ESTKQFSLRTLPSVVSFHLKRFEHSALIDRKISSFIQFPVEFDMTPFMSEKKNAYGDFRFSLYAV 439
            .::...:|.|...|:...||||  |.:...|::..:|:|...||.|:||::..  |...:.||||
Human   262 PASNTLTLHTSAKVLILVLKRF--SDVAGNKLAKNVQYPECLDMQPYMSQQNT--GPLVYVLYAV 322

  Fly   440 VNHVG-TIDTGHYTAYVRHQKDTWVKCDDHVITMASLKQVLDSEGYLLFY 488
            :.|.| :...|||.:||:.|:..|.|.||..:|:.|:..||..:.|:|||
Human   323 LVHAGWSCHDGHYFSYVKAQEVQWYKMDDAEVTVCSIISVLSQQAYVLFY 372

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
not	NP_001287106.1	zf-UBP	46..103	CDD:307999
not	NP_001287106.1	Peptidase_C19D	158..489	CDD:239125	97/344 (28%)
USP17L1	NP_001243802.1	Peptidase_C19E	79..373	CDD:239126	96/338 (28%)
		UCH	80..372	CDD:278850	94/335 (28%)
		HABP4_PAI-RBP1	<426..454	CDD:282609
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.910