DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment not and USP17L7

DIOPT Version :9

Sequence 1:	NP_001287106.1	Gene:	not / 40030	FlyBaseID:	FBgn0013717	Length:	496	Species:	Drosophila melanogaster
Sequence 2:	NP_001243798.1	Gene:	USP17L7 / 392197	HGNCID:	37180	Length:	530	Species:	Homo sapiens

Alignment Length:	376	Identity:	107/376 - (28%)
Similarity:	171/376 - (45%)	Gaps:	64/376 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly   132 PTTKETNLLLAN-----ARRRLVRPNQTIGLR-------GLLNLGATCFMNCIVQALVHTPLLSD 184
            |.:.||...|.:     ||:...|....:..|       ||..:|.|.::|..:|.|.:|..||:
Human    42 PLSSETRFDLCDDLAPVARQLAPREKLPLSSRRPAAVGAGLQKIGNTFYVNVSLQCLTYTLPLSN 106

  Fly   185 YFMSDRHDCGSKSSHK-CLVCEVSRLFQEFYSGSRSPLSLHRLLHLIWNHAKHLAGY---EQQDA 245
            |.:| |.|..:...|| |:.|.:.         :....:||...|:|.......||:   ||:||
Human   107 YMLS-REDSQTCHLHKCCMFCTMQ---------AHITWALHSPGHVIQPSQVLAAGFHRGEQEDA 161

  Fly   246 HEFFIATLDVLHRHCVKA--KAEHESKSNSSGSGSGTNSSNSSSSHCYGQCNCIIDQIFTGMLQS 308
            |||.:.|:|.:.:.|:..  :.:|.||..:                       :|.|||....:|
Human   162 HEFLMFTVDAMKKACLPGHKQLDHHSKDTT-----------------------LIHQIFGAYWRS 203

  Fly   309 DVVCQACNGVSTTYDPFWDISLDLGETTTHGGVTPKTLIDCLERYTRAEHLGSAAKIKCSTCKSY 373
            .:....|:|||.|:||:.||:||:        ...:::...||:..:.:.|.......|..|...
Human   204 QIKYLHCHGVSDTFDPYLDIALDI--------QAAQSVKQALEQLVKPKELNGENAYHCGLCLQK 260

  Fly   374 QESTKQFSLRTLPSVVSFHLKRFEHSALIDRKISSFIQFPVEFDMTPFMSEKKNAYGDFRFSLYA 438
            ..::|..:|.|...|:...||||  |.:...|::..:|:|...||.|:||::..  |...:.|||
Human   261 APASKTLTLPTSAKVLILVLKRF--SDVTGNKLAKNVQYPKCRDMQPYMSQQNT--GPLVYVLYA 321

  Fly   439 VVNHVG-TIDTGHYTAYVRHQKDTWVKCDDHVITMASLKQVLDSEGYLLFY 488
            |:.|.| :...|||.:||:.|:..|.|.||..:|.:.:..||..:.|:|||
Human   322 VLVHAGWSCHNGHYFSYVKAQEGQWYKMDDAEVTASGITSVLSQQAYVLFY 372

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
not	NP_001287106.1	zf-UBP	46..103	CDD:307999
not	NP_001287106.1	Peptidase_C19D	158..489	CDD:239125	100/345 (29%)
USP17L7	NP_001243798.1	Peptidase_C19E	79..373	CDD:239126	99/339 (29%)
		UCH	80..372	CDD:278850	97/336 (29%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	382..412
		HABP4_PAI-RBP1	<426..454	CDD:282609
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	431..454
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	490..530
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.910