DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment not and USP27X

DIOPT Version :9

Sequence 1:	NP_001287106.1	Gene:	not / 40030	FlyBaseID:	FBgn0013717	Length:	496	Species:	Drosophila melanogaster
Sequence 2:	NP_001138545.1	Gene:	USP27X / 389856	HGNCID:	13486	Length:	438	Species:	Homo sapiens

Alignment Length:	447	Identity:	236/447 - (52%)
Similarity:	284/447 - (63%)	Gaps:	69/447 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    97 CRDFIYDARSREYALINRKLEAKDLQKSIGW--------VP--------WVPTTKETNLLLANAR 145
            |:|::|| :..|......:.||..||.|...        ||        |..|..|..||..|.|
Human     2 CKDYVYD-KDIEQIAKEEQGEALKLQASTSTEVSHQQCSVPGLGEKFPTWETTKPELELLGHNPR 65

  Fly   146 RRLVRPNQTIGLRGLLNLGATCFMNCIVQALVHTPLLSDYFMSDRHDCGSKSSHKCLVCEVSRLF 210
            ||.:..:.|||||||:|||.|||||||||||.|||:|.|:|:||||.|...|...|||||:|.||
Human    66 RRRITSSFTIGLRGLINLGNTCFMNCIVQALTHTPILRDFFLSDRHRCEMPSPELCLVCEMSSLF 130

  Fly   211 QEFYSGSRSPLSLHRLLHLIWNHAKHLAGYEQQDAHEFFIATLDVLHRHCVKAKAEHESKSNSSG 275
            :|.|||:.||...::||||:|.||:|||||.|||||||.||.||||||||           ....
Human   131 RELYSGNPSPHVPYKLLHLVWIHARHLAGYRQQDAHEFLIAALDVLHRHC-----------KGDD 184

  Fly   276 SGSGTNSSNSSSSHCYGQCNCIIDQIFTGMLQSDVVCQACNGVSTTYDPFWDISLDL-------- 332
            .|...|:.|        .|||||||||||.|||||.||||:|||||.||.|||||||
Human   185 VGKAANNPN--------HCNCIIDQIFTGGLQSDVTCQACHGVSTTIDPCWDISLDLPGSCTSFW 241

  Fly   333 -----GETTTHG-----GVTPKTLIDCLERYTRAEHLGSAAKIKCSTCKSYQESTKQFSLRTLPS 387
                 .|::.:|     |:|  ||.|||.|:||.|||||:|||||.:|:||||||||.::..||.
Human   242 PMSPGRESSVNGESHIPGIT--TLTDCLRRFTRPEHLGSSAKIKCGSCQSYQESTKQLTMNKLPV 304

  Fly   388 VVSFHLKRFEHSALIDRKISSFIQFPVEFDMTPFMSEKK-------------NAYGDFRFSLYAV 439
            |..||.|||||||...|||:::|.||:|.||||||:..|             :...:.::||:||
Human   305 VACFHFKRFEHSAKQRRKITTYISFPLELDMTPFMASSKESRMNGQLQLPTNSGNNENKYSLFAV 369

  Fly   440 VNHVGTIDTGHYTAYVRHQKDTWVKCDDHVITMASLKQVLDSEGYLLFYHKNVLEYE 496
            |||.||:::||||:::||.||.|.||||.|||.||:|.|||||||||||||.|||:|
Human   370 VNHQGTLESGHYTSFIRHHKDQWFKCDDAVITKASIKDVLDSEGYLLFYHKQVLEHE 426

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
not	NP_001287106.1	zf-UBP	46..103	CDD:307999	2/5 (40%)
not	NP_001287106.1	Peptidase_C19D	158..489	CDD:239125	204/361 (57%)
USP27X	NP_001138545.1	Peptidase_C19D	78..419	CDD:239125	204/361 (57%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	416	1.000	Domainoid score	I655
eggNOG	1	0.900	-	-		E1_KOG1867
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	533	1.000	Inparanoid score	I1213
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG59954
OrthoDB	1	1.010	-	-		D200191at33208
OrthoFinder	1	1.000	-	-		FOG0002382
OrthoInspector	1	1.000	-	-		otm41077
orthoMCL	1	0.900	-	-		OOG6_102914
Panther	1	1.100	-	-	O	PTHR21646
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1591
SonicParanoid	1	1.000	-	-		X1575
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	14	13.910