DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment not and USP17L2

DIOPT Version :9

Sequence 1:	NP_001287106.1	Gene:	not / 40030	FlyBaseID:	FBgn0013717	Length:	496	Species:	Drosophila melanogaster
Sequence 2:	NP_958804.2	Gene:	USP17L2 / 377630	HGNCID:	34434	Length:	530	Species:	Homo sapiens

Alignment Length:	363	Identity:	106/363 - (29%)
Similarity:	170/363 - (46%)	Gaps:	60/363 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly   141 LANARRRLVRPNQTIGL---------RGLLNLGATCFMNCIVQALVHTPLLSDYFMSDRHDCGSK 196
            ||...|:|. |.:.:.|         .||.|:|.||:.|..:|.|.:||.|::|.:|..|....:
Human    55 LAPVARQLA-PRKKLPLSSRRPAAVGAGLQNMGNTCYENASLQCLTYTPPLANYMLSREHSQTCQ 118

  Fly   197 SSHKCLVCEVSRLFQEFYSGSRSPLSLHRLLHLIWNHAKHLAGY---EQQDAHEFFIATLDVLHR 258
            ....|::|.:.         :....:||...|:|.......||:   :|:|||||.:.|:|.:.:
Human   119 RPKCCMLCTMQ---------AHITWALHSPGHVIQPSQALAAGFHRGKQEDAHEFLMFTVDAMKK 174

  Fly   259 HCVKA--KAEHESKSNSSGSGSGTNSSNSSSSHCYGQCNCIIDQIFTGMLQSDVVCQACNGVSTT 321
            .|:..  :.:|.||..:                       :|.|||.|..:|.:.|..|:|:|.|
Human   175 ACLPGHKQVDHHSKDTT-----------------------LIHQIFGGCWRSQIKCLHCHGISDT 216

  Fly   322 YDPFWDISLDLGETTTHGGVTPKTLIDCLERYTRAEHLGSAAKIKCSTCKSYQESTKQFSLRTLP 386
            :||:.||:||:        ...:::...||:..:.|.|.......|..|.....::|..:|.|..
Human   217 FDPYLDIALDI--------QAAQSVKQALEQLVKPEELNGENAYHCGLCLQRAPASKTLTLHTSA 273

  Fly   387 SVVSFHLKRFEHSALIDRKISSFIQFPVEFDMTPFMSEKKNAYGDFRFSLYAVVNHVG-TIDTGH 450
            .|:...||||  |.:...|::..:|:|...||.|:||::..  |...:.||||:.|.| :...||
Human   274 KVLILVLKRF--SDVTGNKLAKNVQYPECLDMQPYMSQQNT--GPLVYVLYAVLVHAGWSCHDGH 334

  Fly   451 YTAYVRHQKDTWVKCDDHVITMASLKQVLDSEGYLLFY 488
            |.:||:.|:..|.|.||..:|..|:..||..:.|:|||
Human   335 YFSYVKAQEGQWYKMDDAKVTACSITSVLSQQAYVLFY 372

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
not	NP_001287106.1	zf-UBP	46..103	CDD:307999
not	NP_001287106.1	Peptidase_C19D	158..489	CDD:239125	100/337 (30%)
USP17L2	NP_958804.2	Peptidase_C19E	79..373	CDD:239126	100/338 (30%)
		UCH	80..372	CDD:278850	98/335 (29%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	382..416
		Mediates interaction with SUDS3. /evidence=ECO:0000269\|PubMed:21239494	399..530
		HABP4_PAI-RBP1	<426..454	CDD:282609
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	490..530
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910