Protein Alignment not and USP50

DIOPT Version :10

• Sequence 1: NP_001401041.1
• Gene: not / 40030
• FlyBaseID: FBgn0013717
• Length: 703
• Species: Drosophila melanogaster
• Sequence 2: NP_987090.2
• Gene: USP50 / 373509
• HGNCID: 20079
• Length: 334
• Species: Homo sapiens
• Alignment Length: 326
• Identity: 93/326 - (28%)
• Similarity: 144/326 - (44%)
• Gaps: 62/326 - (19%)

  Fly   363 GLRGLLNLGATCFMNCIVQALVHTPLLSDYFMSDRH------DCGSKSSHKCLVCEVSRLFQEFY 421
            |:.||.|||.||.:|.|.|.|.....|.:||::.::      ||..      :....:.|..:.:
Human    42 GVTGLWNLGNTCCVNAISQCLCSILPLVEYFLTGKYITALQNDCSE------VATAFAYLMTDMW 100

  Fly   422 SGSRSPLSLHRLLHLIWNHAKHLAGYE------QQDAHEFFIATLDVLHRHCVKAKAEHESKSNS 480
            .|....:|    ..:.|:...:|  |.      ||||.||.|..|:.||.   ..|..|.|:..|
Human   101 LGDSDCVS----PEIFWSALGNL--YPAFTKKMQQDAQEFLICVLNELHE---ALKKYHYSRRRS 156

  Fly   481 SGSGSGTNSSNSSSSHCYGQC-------NCIIDQIFTGMLQSDVVCQACNGVSTTYDPFWDISLD 538
            ...|        |:..|   |       ..||.|:|...|...:||..|...:...:.|...||.
Human   157 YEKG--------STQRC---CRKWITTETSIITQLFEEQLNYSIVCLKCEKCTYKNEVFTVFSLP 210

  Fly   539 LGETTTHGGVTPK----TLIDCLERYTRAEHLGSAAKIKCSTCKSYQESTKQFSLRTLPSVVSFH 599
            :          |.    :|.|||:.:.:.:.|....:|.||.|::.||:..:.|:...|.::.||
Human   211 I----------PSKYECSLRDCLQCFFQQDALTWNNEIHCSFCETKQETAVRASISKAPKIIIFH 265

  Fly   600 LKRFEHSALIDRKISSFIQFPV-EFDMTPFMSEKKNAYGDFRFSLYAVVNHVGTIDTGHYTAYVR 663
            ||||:......||:.:.|.:|: ..|:||::......|.  :::|.|||||.|.:|.|||||:.:
Human   266 LKRFDIQGTTKRKLRTDIHYPLTNLDLTPYICSIFRKYP--KYNLCAVVNHFGDLDGGHYTAFCK 328

  Fly   664 H 664
            :
Human   329 N 329

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
not	NP_001401041.1	zf-UBP	253..310	CDD:460464
		Peptidase_C19D	365..696	CDD:239125	92/324 (28%)
USP50	NP_987090.2	UCH	44..329	CDD:425685	92/322 (29%)