Protein Alignment not and Usp19

DIOPT Version :10

• Sequence 1: NP_001401041.1
• Gene: not / 40030
• FlyBaseID: FBgn0013717
• Length: 703
• Species: Drosophila melanogaster
• Sequence 2: XP_006243855.1
• Gene: Usp19 / 361190
• RGDID: 1303276
• Length: 1359
• Species: Rattus norvegicus
• Alignment Length: 1204
• Identity: 202/1204 - (16%)
• Similarity: 318/1204 - (26%)
• Gaps: 581/1204 - (48%)

  Fly    12 EIETRKASEKSQKFTKKKPNYFQNWAARRR-----TAKVAKIRRKQRKCDKAFVPLQ--SSAKRA 69
            :::|||.........||.|  ...|.:..:     ...|..:|.::...:.:.:.|:  |..:||
  Rat   114 KVQTRKGGLLQLALPKKVP--LLTWPSLLKKPLGTQELVPGLRCQENGQELSPIALEPGSEPRRA 176

  Fly    70 KTKENSVDSNTSVFSSSSSSSSGRSFGRGTERWAV----GAEAGRGTAENETLAVAAAAATTTNA 130
            |.:..:...........|.:|.|...|...:| ||    |.| |.|:.:        ......:|
  Rat   177 KQEARNQKRAQGRGEVGSGASPGAQAGPSAKR-AVHLCRGPE-GEGSMD--------GPGPQGDA 231

  Fly   131 GRFITADLIKTVNSDKQRDRVAKGHRDAKNP----LDATKHLRLSDCLRTVQKLA-----IELES 186
            ..|: :|....|.:::|.      |....||    |.:.|:|.|....:||...:     :.:.:
  Rat   232 PSFL-SDSATQVEAEEQL------HVPPVNPQTSLLGSEKNLALLTVEKTVSPRSDSVSPVMIRN 289

  Fly   187 ADAGSD--------ASAQANASADASSAVMSETGCRH--YQS---------YVKEHSYDTFRVI- 231
            .|...|        ..|...|.||...::::....::  |:.         ||||...||.||:
  Rat   290 RDPEKDDHFKEEMAVGADPAALADEPESMVNLAFVKNDSYEKGPDSVVVHVYVKESRRDTSRVLF 354

  Fly   232 --DAYFAACVNRDARERKAIHCNCFECGSYGIQLYACLHCIYFGCRGAHITSHLRSKKHNVALEL 294
              ..:......||              |:: ::|:.       || |.|.....:.|..|: :|.
  Rat   355 REQDFTLIFQTRD--------------GNF-LRLHP-------GC-GPHTIFRWQVKLRNL-IEP 395

  Fly   295 SHGTLYCYACRDFIYDARSREYALINRK------LEAKDLQKSIGW----VPWVPT--------- 340
            ...|        |.:.|...:..|..|:      |||...:.::|.    ||..||
  Rat   396 EQCT--------FCFTASRIDICLRKRQSQRWGGLEAPATRGAVGGAKVAVPTGPTPLDSTPPGG 452

  Fly   341 ----------------------TKETNLLLANARR-----------RLVRPNQTI---------- 362
                                  ::::.|....||.           .|..|..|.
  Rat   453 GPLPLTGQEEARAVEKEKPKARSEDSGLDGVVARTPLEHVTPKPEPHLASPKPTCMVPPMPHSPV 517

  Fly   363 ------------------GLRGLLNLGATCFMNCIVQALVHTPLLSDYFMSDRHD---------- 399
                              |..||:|||.|||||.::|:|.:|..|.|:|    ||
  Rat   518 SGDSVEEDEEEEKKVCLPGFTGLVNLGNTCFMNSVIQSLSNTRELRDFF----HDRSFEAEINYN 578

  Fly   400 ----CGSKSSHKCLVCEVSRLFQEFYSGSRSPLSLHRLLHLIWNHAKHLAGYEQQDAHEFFIATL 460
                .|.:     |....:.|.:..:.|:.......:|..::.:.|....||.|.||.||....|
  Rat   579 NPLGTGGR-----LAIGFAVLLRALWKGTHQAFQPSKLKAIVASKASQFTGYAQHDAQEFMAFLL 638

  Fly   461 DVLHRHCVKAKAEHESKS-NSSGSGSGTNSSNSSSSHCYGQCNCIIDQIFTGMLQSDVVCQACNG 524
            |.||....:.:.:..::: :|.|......:..:...|.....:.|:| :|.|..:|.:||..|..
  Rat   639 DGLHEDLNRIQNKPYTETVDSDGRPDEVVAEEAWQRHKMRNDSFIVD-LFQGQYKSKLVCPVCAK 702

  Fly   525 VSTTYDPFWDI------------------------------------------------------ 535
            ||.|:|||..:
  Rat   703 VSITFDPFLYLPVPLPQKQKVLPIYYFAREPHSKPIKFLVSVSKENSSASEVLESLSQSVHVKPE 767

  Fly   536 --------------------SLDL----------------------------------------- 539
                                |||.
  Rat   768 SLRLAEVIKNRFHRVFLPSHSLDAVSPTDVLLCFELLSPELAKERVVVLEVQQRPQVPSIPISKC 832

  Fly   540 ----------------------------------------------------------------- 539
                                                                             
  Rat   833 AACQRKQQSEDEKLKRCTRCYRVGYCNQFCQKTHWPDHKGLCRPENIGYPFLVSVPASRLTYARL 897

  Fly   540 ----------------------------------------------------------------- 539
                                                                             
  Rat   898 AQLLEGYARYSVSVFQPPFQPGRMALESQSPGCTTLLSTSSLEAGDSEREPIQPSELQLVTPVAE 962

  Fly   540 GETTTH--------------GGV-----------------------------------------T 549
            |:|..|              .|:                                         |
  Rat   963 GDTGAHRMWPPADRGPVPSTSGISSEMLASGPMEGCSLLAGERVSRPEAAVPGYQHSRESVSAHT 1027

  Fly   550 PK--------------------------------------------------------------- 551
            |:
  Rat  1028 PQFFIYKIDASSREQRLEDKGDTPLELGDDCSLALVWRNNERLQEFVLVASKELECAEDPGSAGE 1092

  Fly   552 -------TLIDCLERYTRAEHLGSAAKIKCSTCKSYQESTKQFSLRTLPSVVSFHLKRFEHSALI 609
                   ||..||..:||.|.|.......|..||.::|::||..|..||:|:...||||...:.|
  Rat  1093 AARAGHFTLDQCLNLFTRPEVLAPEEAWYCPQCKQHREASKQLLLWRLPNVLIVQLKRFSFRSFI 1157

  Fly   610 DR-KISSFIQFPV-EFDMTPF-MSEKKNAYGDFRFSLYAVVNHVGTIDTGHYTAYVRHQKDT--- 668
            .| ||:..::||| ..|::.| :.:|:.....  :.||||:||.|.:..|||||..|...|.
  Rat  1158 WRDKINDLVEFPVRNLDLSKFCIGQKEEQLPS--YDLYAVINHYGGMIGGHYTACARLPSDRSSQ 1220

  Fly   669 -----WVKCDDHVITMASLKQVLDSEGYLLFYHK 697
                 |...||..:|.....||:....|:|||.:
  Rat  1221 RSDVGWRLFDDSTVTTVDESQVVTRYAYVLFYRR 1254

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
not	NP_001401041.1	zf-UBP	253..310	CDD:460464	11/56 (20%)
		Peptidase_C19D	365..696	CDD:239125	116/726 (16%)
Usp19	XP_006243855.1	p23_like	58..140	CDD:107220	7/27 (26%)
		p23_CS_SGT1_like	327..423	CDD:107223	25/127 (20%)
		USP19_linker	414..536	CDD:465191	15/121 (12%)
		UBP12	<534..1256	CDD:227847	118/733 (16%)