DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment not and usp14

DIOPT Version :9

Sequence 1:	NP_001287106.1	Gene:	not / 40030	FlyBaseID:	FBgn0013717	Length:	496	Species:	Drosophila melanogaster
Sequence 2:	NP_956267.1	Gene:	usp14 / 335736	ZFINID:	ZDB-GENE-030131-7676	Length:	489	Species:	Danio rerio

Alignment Length:	416	Identity:	85/416 - (20%)
Similarity:	147/416 - (35%)	Gaps:	115/416 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly   159 GLLNLGATCFMNCIVQALVHTPLLSD---YFMSDRHDCGSKSSHKCLVCEVSRLFQEF--YSGSR 218
            ||.|||.||:||..||.|...|.|..   .:.......|:.:..:.:...:..|::..  .|.|.
Zfish   106 GLTNLGNTCYMNATVQCLRSVPELKGALRRYSGALRSSGANAPSQYITAALRDLYESMDKTSSSI 170

  Fly   219 SPLSLHRLLHLIWNHAKHLAG---YEQQDAHEFFIATLDVLHRHCVKAKAEHESKSNSSGSGSGT 280
            .|:.|.:.||:.:........   |.||||:|.::..:.||.:..  ...|.|:...:.|..:..
Zfish   171 PPIILLQFLHMAFPQFAEKGDQGQYLQQDANECWVQVMRVLQQKL--EPQEPETPMETDGDSAAA 233

  Fly   281 NSSNSSSSHCYGQCNCIIDQIFTGMLQSDVVCQACNGVSTTYDPFWDISLDLGETTTHGGVTPKT 345
            .|:...|         .|||.|....::.:.|........|                 .|...:.
Zfish   234 ASTKKKS---------FIDQYFGVEFETSMKCTEAEDEEPT-----------------KGTESQL 272

  Fly   346 LIDCLERYTRAEHLGSAAKIKCSTCKSYQESTKQFS--------------LRTLPSVVSFHLKRF 396
            .:.|... ...::|.:..:::      .||...:||              :..||:..:..:.||
Zfish   273 QLSCFIN-QEVKYLATGLRLR------LQEDITKFSPSLQRNALYIKSSKISRLPAYHTVQMVRF 330

  Fly   397 --EHSALIDRKISSFIQFPVEFDM----TPFMSE------------------------------- 424
              :....::.|:...::||:..|:    |..:.|
Zfish   331 FYKEKESVNAKVLKDVKFPLMLDVYELCTSELQEKMVSLRSKFKEMEDKKLEKQQKSEPNKKPGA 395

  Fly   425 -KKNAYGDFRF------------SLYAVVNHVG-TIDTGHYTAYVRHQKDTWVKCDDHVITMASL 475
             |:..|..|.|            .|.||:.|.| :..:|||.|:|:.::|.|||.||..:::.:.
Zfish   396 LKETKYEPFSFPDDLGSNNSGYYELQAVLTHQGRSSSSGHYVAWVKRKEDEWVKFDDDKVSVVTP 460

  Fly   476 KQVLDSEG-------YLLFYHKNVLE 494
            :.:|...|       |:|.|....||
Zfish   461 EDILKLSGGGDWHIAYVLLYGPRRLE 486

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
not	NP_001287106.1	zf-UBP	46..103	CDD:307999
not	NP_001287106.1	Peptidase_C19D	158..489	CDD:239125	82/409 (20%)
usp14	NP_956267.1	UBQ	4..74	CDD:214563
		UBQ	5..74	CDD:294102
		UCH	104..480	CDD:278850	82/408 (20%)
		Peptidase_C19A	106..481	CDD:239122	82/409 (20%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910