DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment not and HDAC6

DIOPT Version :9

Sequence 1:	NP_001287106.1	Gene:	not / 40030	FlyBaseID:	FBgn0013717	Length:	496	Species:	Drosophila melanogaster
Sequence 2:	NP_001259569.1	Gene:	HDAC6 / 32461	FlyBaseID:	FBgn0026428	Length:	1179	Species:	Drosophila melanogaster

Alignment Length:	216	Identity:	50/216 - (23%)
Similarity:	77/216 - (35%)	Gaps:	71/216 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly    46 CFECGSYGIQLYACLHCIYFGCR---GAHITSHLRSKKHNVALELSHGTLYCYACRDFIYDARSR 107
            |..|||.| :.:.||.|.:..|.   .||:..|...::|.:|:..:..:::||||..::  ...|
  Fly  1007 CSVCGSTG-ENWVCLSCRHVACGRYVNAHMEQHSVEEQHPLAMSTADLSVWCYACSAYV--DHPR 1068

  Fly   108 EYALINRKLEAKDLQKSIGWV---PW--------VPTTKE----------TNLLLANARRRLVRP 151
            .||.:|...|.| .|:.:.|.   .|        .|..::          :::.|     ||.|.
  Fly  1069 LYAYLNPLHEDK-FQEPMAWTHGCAWREDGCYATGPDGRDEDDDDDNGAGSSICL-----RLERN 1127

  Fly   152 NQTIGLRGLLNLGATCFMNCIVQALVHTPLLSDYFMSDRHDCGSKSSHKCLVCEVSRLFQEFYSG 216
            | .:.:|.|                   ..|:||.              |.:|...|....|.:.
  Fly  1128 NXPLAIRVL-------------------DALTDYL--------------CALCPPLRHLIHFLAE 1159

  Fly   217 SRSPLSLHR----LLHLIWNH 233
            ...|| |.|    |||....|
  Fly  1160 HLWPL-LERIYLNLLHYFLAH 1179

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
not	NP_001287106.1	zf-UBP	46..103	CDD:307999	18/59 (31%)
not	NP_001287106.1	Peptidase_C19D	158..489	CDD:239125	17/80 (21%)
HDAC6	NP_001259569.1	HDAC10_HDAC6-dom1	119..457	CDD:212526
		HDAC6-dom2	538..895	CDD:212527
		zf-UBP	1007..1069	CDD:280334	18/64 (28%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1867
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.900