Protein Alignment not and usp19

DIOPT Version :10

• Sequence 1: NP_001401041.1
• Gene: not / 40030
• FlyBaseID: FBgn0013717
• Length: 703
• Species: Drosophila melanogaster
• Sequence 2: XP_005162175.2
• Gene: usp19 / 324335
• ZFINID: ZDB-GENE-030131-3055
• Length: 1485
• Species: Danio rerio
• Alignment Length: 1220
• Identity: 198/1220 - (16%)
• Similarity: 322/1220 - (26%)
• Gaps: 614/1220 - (50%)

  Fly    17 KASEKSQKFTKKKPNYFQNWAARRRTAKVAKIRRKQRKCDKAFVPLQSSAKRAKTKENSVDSNTS 81
            |:|:|:...         |..:.:||.:.:|..:     :....|...:..::|...|.....:.
Zfish   217 KSSDKADSI---------NEPSAKRTTRPSKNTK-----EPPLAPCLGNESKSKATVNGKTHTSE 267

  Fly    82 VFSSSSSSSS---------GRSFG-------RGTERWAVGAEAGRGTAENETLAV---------- 120
            |.|.:||||:         |:..|       :|.:| ...:.|..|:.|:::::|
Zfish   268 VNSGASSSSNAKDNRAQMQGKPQGCQALQKEKGIDR-KPKSNAQVGSGESKSVSVCEPQVPQKEH 331

  Fly   121 AAAAATTTNAGRFITADLIKTVNSDKQRDRVAKGHRDAKNPLDATKHLRLSDCLRTVQKLAIELE 185
            ::...|.|:.   |.:|  :..|..::....|:||                     :.|:   |.
Zfish   332 SSPVKTCTDK---IASD--EPENRKEETKPQAEGH---------------------IPKM---LP 367

  Fly   186 SADAGSDASAQANASADASSAVMSETGCRHYQS-----------------------YVKEHSYD- 226
            |.|.||...|..:..:: .|...|:|..:..:|                       :||..||:
Zfish   368 SHDLGSGEPASTDFKSE-ESPQKSQTEEKRDKSKEEPQGASQEEDTEGPEPMVDLKFVKNDSYEK 431

  Fly   227 --TFRVIDAYFAACVNRDA----RERK-------------AIHCNCFECGSYGIQLYACLHCIYF 272
              ...|::.|......:.:    ||:.             .:|.:|
Zfish   432 GTDLMVVNVYMKEICRQTSRVLFREQDFTLIFQTSDPNFLRLHSDC------------------- 477

  Fly   273 GCRGAHITSHLRSKKHN-----------------VALELSH----GTLYCYACRDFIYDAR---- 312
               |.:.....:.|..|                 :.|:..|    |.|...|.:..:..|:
Zfish   478 ---GPNTVFKWQVKLRNLIQPDQSNYAFTPSRIDITLKKRHSQRWGGLEAPATQGAVGGAKVAVA 539

  Fly   313 ------------SREYALINRK-------------------LEAKDLQK-----SIGWVPWVPTT 341
                        |.::||..::                   |:|...:.     |:...|.|.|.
Zfish   540 SSPSTLEKSQPGSSQHALPAKEEPRVGEEKPKPPRAPEDSGLDAVSPRSVSEHVSLKQEPAVATP 604

  Fly   342 KETNLL--------LANARRRLVRPNQTI--GLRGLLNLGATCFMNCIVQALVHTPLLSDYFMSD 396
            |.|.::        :.|.|...|...:..  |..||:|||.|||||.::|:|.:|..|.|||
Zfish   605 KPTCMVQPMTHTPPVGNERSEEVEEKKVCHPGFTGLVNLGNTCFMNSVIQSLSNTRELRDYF--- 666

  Fly   397 RHDCGSKSSHKC---------LVCEVSRLFQEFYSGSRSPLSLHRLLHLIWNHAKHLAGYEQQDA 452
             ||.|.:|...|         |....:.|.:..:.|:.......:|..::.:.|....||.|.||
Zfish   667 -HDRGFESEINCNNPLGTGGRLAIGFAVLLRALWKGTHHAFQPSKLKAIVASKASQFTGYAQHDA 730

  Fly   453 HEFFIATLDVLHRHCVKAKAEHESKS-NSSGSGSGTNSSNSSSSHCYGQCNCIIDQIFTGMLQSD 516
            .||....||.||....:.:.:..::: :|.|......:..:...|.....:.|:| :|.|..:|.
Zfish   731 QEFMAFLLDGLHEDLNRIQNKPYTETVDSDGRQDEVVAEEAWQRHKMRNDSFIVD-LFQGQYKSK 794

  Fly   517 VVCQACNGVSTTYDPF------------------------------------------------- 532
            :||..|:.||.|:|||
Zfish   795 LVCPMCSKVSITFDPFLYLPVPLPQKQKVLTVFYFAKEPHKKPVKFLVSVSKESSSTAEVLESIS 859

  Fly   533 ----------------------------------------------------------------- 532
                                                                             
Zfish   860 RSVRIKPENLRLTEVVKGRFHRIFLPSQSLDTVSSSDLLFCFEMLSKDLIKERVVLLKVQQRPQI 924

  Fly   533 ------------------------------------------W---------------------- 533
                                                      |
Zfish   925 PSIPITKCAGCLKPPASDDEKLKRCTRCYRVGYCNQTCQKNHWPSHKTMCRSNVENIGQPFLISV 989

  Fly   534 ----------------------------------------------------------------- 533
                                                                             
Zfish   990 PESRLSYTRLTQLLEGYSRYSVNVFQPPFQSGRTSPESSLSRVDLTSMASSVPECQEKDLPSAGD 1054

  Fly   534 ----------------DISLDLGET----TTHGG----------------------VTPK----- 551
                            :.:.|.|:|    ||..|                      |.|:
Zfish  1055 AENPAEQDESVTASQTESAADGGDTLSTHTTDSGCCELASSSHDSLLEKETSCEKAVKPEAVVTG 1119

  Fly   552 ----------------------------------------------------------------- 551
                                                                             
Zfish  1120 YQQPSESASGGASQFYITILDSSQKEDKKLEEKGDAVLELPDECTLELVWKNNERQKEYVLVRSK 1184

  Fly   552 --------------------TLIDCLERYTRAEHLGSAAKIKCSTCKSYQESTKQFSLRTLPSVV 596
                                ||..||..:|:.|.|.......|..|:.::|::||..|..||:|:
Zfish  1185 DLEFDEDPGSATETSRAGHFTLEQCLNLFTKPEVLAPEEAWYCPKCQQHREASKQLLLWRLPNVL 1249

  Fly   597 SFHLKRFEHSALIDR-KISSFIQFPV-EFDMTPFMSEKKNAYGDFR----FSLYAVVNHVGTIDT 655
            ...||||...:.|.| ||:..:.||| ..|::.|....|   ||.:    :.||||:||.|.:..
Zfish  1250 IIQLKRFSFRSFIWRDKINDMVDFPVRNLDLSKFCIGHK---GDIQQPPIYDLYAVINHYGGMIG 1311

  Fly   656 GHYTAYVRHQKDT--------WVKCDDHVITMASLKQVLDSEGYLLFYHK 697
            ||||||.|...|.        |...||..:|.....||:....|:|||.:
Zfish  1312 GHYTAYARLPSDKNSQLSDVGWRLFDDSTVTTVEESQVVTRYAYVLFYRR 1361

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
not	NP_001401041.1	zf-UBP	253..310	CDD:460464	9/77 (12%)
		Peptidase_C19D	365..696	CDD:239125	120/729 (16%)
usp19	XP_005162175.2	None