DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment not and Usp7

DIOPT Version :9

Sequence 1:	NP_001287106.1	Gene:	not / 40030	FlyBaseID:	FBgn0013717	Length:	496	Species:	Drosophila melanogaster
Sequence 2:	NP_572779.2	Gene:	Usp7 / 32169	FlyBaseID:	FBgn0030366	Length:	1129	Species:	Drosophila melanogaster

Alignment Length:	412	Identity:	102/412 - (24%)
Similarity:	166/412 - (40%)	Gaps:	74/412 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly   101 IYDARSREYALIN--RKLEAKDLQKSIGWVPWVPTTKETNLLLANARRRLVRPNQTIGLRGLLNL 163
            ::.::..:|...|  ...|.||.:||  :|.....|.|.:::.......|....:..|..||.|.
  Fly   184 LFYSKENDYGYSNFITWQELKDSEKS--YVHNNSITLEVHVVADAPHGVLWDSKKHTGYVGLKNQ 246

  Fly   164 GATCFMNCIVQALVHTP--LLSDYFMSDRHDCGSKSSHKCLVCEVSRLFQEFYSGSRSPLSLHRL 226
            ||||:||.::|.|..|.  .||.|.:....|..|||    :...:.|:|.|...|.| |:...:|
  Fly   247 GATCYMNSLLQTLYFTNSLRLSVYRIPTEADDSSKS----VGLSLQRVFHELQFGDR-PVGTKKL 306

  Fly   227 LHLI-WNHAKHLAGYEQQDAHEFFIATLDVLHRHCVKAKAEHESKSNSSGSGSGTNSSNSSSSHC 290
            .... |   :.|..:.|.|..||....||.|           |||.      .||....:
  Fly   307 TKSFGW---ETLDSFMQHDVQEFLRVLLDKL-----------ESKM------KGTILEGT----- 346

  Fly   291 YGQCNCIIDQIFTGMLQSDVVCQACNGVSTTYDPFWDISLDLGETTTHGGVTPKTLIDCLERYTR 355
                   |..:|.|.:.|.:.|:..:..||.|:.|:||.|::.:        .|.:.:..:.|..
  Fly   347 -------IPGLFEGKMSSYIKCKNVDYNSTRYETFYDIQLNIKD--------KKNIYESFQDYVA 396

  Fly   356 AEHLGSAAKIKCSTCKSYQESTKQFSLRTLPSVVSFHLKRFEHSALIDR--KISSFIQFPVEFDM 418
            .|.|....|..... ...||::|.....:.|.|:..||.||::..:.|.  |.:...:|....::
  Fly   397 PETLEGDNKYDAGV-HGLQEASKGVIFTSFPPVLHLHLMRFQYDPVTDSSIKYNDRFEFYEHINL 460

  Fly   419 TPFMSEKKNAYGDFRFSLYAVVNHVGTIDTGHYTAYVRHQKD-TWVKCDDHVITMASLKQVLD-- 480
            ..:::|.:|...|  :.|:||:.|.|....|||..::..:.| .|.|.||.|::....::.::
  Fly   461 DRYLAESENTLAD--YVLHAVLVHSGDNHGGHYVVFINPKADGRWFKFDDDVVSSCRKQEAIEQN 523

  Fly   481 --------------SEGYLLFY 488
                          |..|:|.|
  Fly   524 YGGMDDEISFHAKCSNAYMLVY 545

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
not	NP_001287106.1	zf-UBP	46..103	CDD:307999	0/1 (0%)
not	NP_001287106.1	Peptidase_C19D	158..489	CDD:239125	90/353 (25%)
Usp7	NP_572779.2	MATH_HAUSP	100..229	CDD:239741	10/46 (22%)
		COG5077	101..1119	CDD:227409	102/412 (25%)
		peptidase_C19C	239..549	CDD:239124	91/355 (26%)
		USP7_ICP0_bdg	647..886	CDD:289221
		USP7_C2	897..1113	CDD:291217
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45456865
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	1.840