DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment not and Usp13

DIOPT Version :9

Sequence 1:NP_001287106.1 Gene:not / 40030 FlyBaseID:FBgn0013717 Length:496 Species:Drosophila melanogaster
Sequence 2:NP_001101135.1 Gene:Usp13 / 310306 RGDID:1306044 Length:858 Species:Rattus norvegicus


Alignment Length:565 Identity:95/565 - (16%)
Similarity:160/565 - (28%) Gaps:257/565 - (45%)


- Green bases have known domain annotations that are detailed below.


  Fly   149 VRPNQTIGLRGLLNLGATCFMNCIVQALV-----------HTPLLSDY--------FMSDRHDCG 194
            ::|....|..||.|||.:|:::.::||:.           :.|.:.||        |.:.....|
  Rat   325 LKPMYGPGYTGLKNLGNSCYLSSVMQAIFSIPEFQRAYVGNLPRIFDYSPLDPTQDFNTQMTKLG 389

  Fly   195 ---------------------SKSSHKCLVCEVS-RLFQEFYSGSRSPLSLHRLLHLIWNHAKHL 237
                                 .|..||.....:| |:|:.|.|.|....|.:|            
  Rat   390 HGLLSGQYSKPPVKSELIEQVMKEEHKPQQNGISPRMFKAFVSKSHPEFSSNR------------ 442

  Fly   238 AGYEQQDAHEFFIATLDVLHRH------------------------------------------- 259
                ||||.|||:..::::.|:                                           
  Rat   443 ----QQDAQEFFLHLVNLVERNRIGSENPSDVFRFLVEERIQCCQTRKVRYTERVDYLMQLPVAM 503

  Fly   260 --------------------------------------CVKAKAEHESKSNSSGSGSGTNSSNSS 286
                                                  |::|.||.::..:...|.....|:...
  Rat   504 EAATNKDELIAYELMRREAETNRRPLPELVRAKIPFSACLQAFAEPDNVDDFWSSALQAKSAGVK 568

  Fly   287 SSHCYGQCNCIIDQI--FTGMLQ---------------SDVVCQACNGVSTTYDPFWDIS----- 329
            :|........::.||  ||..|.               .|:......|:....:...|||     
  Rat   569 TSRFASFPEYLVVQIKKFTFGLDWVPRKFDVSIDMPDLLDISHLRARGLQPGEEELPDISPPIVI 633

  Fly   330 ---------------LDLGETT-----------------------THGGVTPKTLIDCLERYTRA 356
                           .|:.|::                       |...|....:|..:|....|
  Rat   634 PDDSKDRLMNQLIDPSDIDESSVMQLAEMGFPLEACRKAVYFTGNTGAEVAFNWIIVHMEEPDFA 698

  Fly   357 EHL------GSAAK---------------IKCSTCKSYQESTKQFSLRTLPSVVSFHLKR----- 395
            |.|      |:.|.               :...|...:|.|....:|:    ..:.:|:|     
  Rat   699 EPLAIPGYGGAGASAFGATGLDNQPPEEIVAIITAMGFQRSQAVQALQ----ATNHNLERALDWI 759

  Fly   396 FEHSALIDRKISSFIQFPVEFDMTPFMSEKKNAY--------------GDFRFSLYAVVNHVGTI 446
            |.|.           :|..:.|....|....||.              |...:.|:|.::|:||.
  Rat   760 FSHP-----------EFEEDSDFVIEMENNANANIMSEAKPEGPRVKDGSGMYELFAFISHMGTS 813

  Fly   447 D-TGHYTAYVRHQKDTWVKCDDHVITMASLKQVLDSEGYLLFYHK 490
            . :|||..::: ::..||..:||.: .||.:...|. ||:.||.:
  Rat   814 TMSGHYVCHIK-KEGRWVIYNDHKV-CASERPPKDL-GYMYFYRR 855

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
notNP_001287106.1 zf-UBP 46..103 CDD:307999
Peptidase_C19D 158..489 CDD:239125 92/553 (17%)
Usp13NP_001101135.1 UBP14 28..856 CDD:227532 95/565 (17%)
zf-UBP 209..282 CDD:280334
Peptidase_C19B 335..854 CDD:239123 92/552 (17%)
UBA1_UBP13 650..698 CDD:270567 6/47 (13%)
UBA2_UBP5 723..764 CDD:270569 8/55 (15%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
10.910

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