DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment not and Usp21

DIOPT Version :9

Sequence 1:	NP_001287106.1	Gene:	not / 40030	FlyBaseID:	FBgn0013717	Length:	496	Species:	Drosophila melanogaster
Sequence 2:	NP_038947.2	Gene:	Usp21 / 30941	MGIID:	1353665	Length:	566	Species:	Mus musculus

Alignment Length:	357	Identity:	105/357 - (29%)
Similarity:	161/357 - (45%)	Gaps:	40/357 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly   159 GLLNLGATCFMNCIVQALVHTPLLSDYFMSDRHDCGSKSSHKCLVCEVSRLFQE-----FYSGSR 218
            ||.|||.|||:|.::|.|..|..|.|:.:  |.|...:........|::..|.:     ::..|.
Mouse   213 GLRNLGNTCFLNAVLQCLSSTRPLRDFCL--RRDFRQEVPGGGRAQELTEAFADVIGALWHPDSC 275

  Fly   219 SPLSLHRLLHLIWNHAKHLAGYEQQDAHEFFIATLDVLHRH---------------------CVK 262
            ..::..|...:...:....:||.||||.||....::.||..                     |..
Mouse   276 EAVNPTRFRAVFQKYVPSFSGYSQQDAQEFLKLLMERLHLEINRRGRRAPPILASGPVPSPPCRG 340

  Fly   263 AKAEHESKSNSSGSGSGTNSSNSSSSHCYGQCNCIIDQIFTGMLQSDVVCQACNGVSTTYDPFWD 327
            ..|.||....|...    .::.....:...:.:.|:| :|.|.|:|.:.||||...|||::.|.|
Mouse   341 GGALHEEPELSDDD----RANLMWKRYLEREDSKIVD-LFVGQLKSCLKCQACGYRSTTFEVFCD 400

  Fly   328 ISLDLGETTTHGGVTPKTLIDCLERYTRAEHLGSAAKIKCSTCKSYQESTKQFSLRTLPSVVSFH 392
            :||.:.:....||..  :|.||...:|:.|.|.|.....|..|:....|||:.:::..|.::..|
Mouse   401 LSLPIPKKGFAGGKV--SLRDCFSLFTKEEELESENAPVCDRCRQKTRSTKKLTVQRFPRILVLH 463

  Fly   393 LKRFEHSALIDRKISSFIQFPVE-FDMTPFMSEKKNAYGDFRFSLYAVVNHVGTIDTGHYTAYVR 456
            |.||..|....:|.|..:.||:: ..:..|.|:|.   |...:.|||:.||.|::..|||||..|
Mouse   464 LNRFSTSRGSIKKSSVGVDFPLQRLSLGDFASDKA---GSPVYQLYALCNHSGSVHYGHYTALCR 525

  Fly   457 HQKDTWVKCDDHVITMASLKQVLDSEGYLLFY 488
            .|.. |...:|..::..|..||..||||:|||
Mouse   526 CQTG-WHVYNDSRVSPVSENQVASSEGYVLFY 556

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
not	NP_001287106.1	zf-UBP	46..103	CDD:307999
not	NP_001287106.1	Peptidase_C19D	158..489	CDD:239125	105/357 (29%)
Usp21	NP_038947.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..103
		Nuclear export signal. /evidence=ECO:0000250	134..152
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	146..169
		UCH	212..556	CDD:278850	103/355 (29%)
		Peptidase_C19R	213..557	CDD:239139	105/357 (29%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	324..349		4/24 (17%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910