DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment not and Usp27x

DIOPT Version :9

Sequence 1:	NP_001287106.1	Gene:	not / 40030	FlyBaseID:	FBgn0013717	Length:	496	Species:	Drosophila melanogaster
Sequence 2:	XP_006256824.2	Gene:	Usp27x / 302566	RGDID:	1564628	Length:	756	Species:	Rattus norvegicus

Alignment Length:	541	Identity:	272/541 - (50%)
Similarity:	342/541 - (63%)	Gaps:	71/541 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 GCRHYQSY-VKEHSYDTFRVIDAYFAACVNRDARERKAIHCNCFECGSYGIQLYACLHCIYFGC- 67
            ||.|..:: |.|:.....|||...|..|...:.|:.||..|.|..||::..:|::||.|::|||
  Rat   226 GCSHVNTFKVGENWRQELRVIYQCFVWCGTPETRKSKAKSCVCHVCGTHLNRLHSCLSCVFFGCF 290

  Fly    68 RGAHITSHLRSKKHNVALELSHGTLYCYACRDFIYDARSREYALINRKLEAKDLQKSIGW----- 127
            ...||..|..:|:||:|::|.:|.:||:.|:|::||....:.|. ..:.||..||.|...
  Rat   291 TEKHIHEHAETKQHNLAVDLYYGGIYCFMCKDYVYDIDIEQIAK-EEQGEALKLQASTSTEFSQQ 354

  Fly   128 ---VP--------WVPTTKETNLLLANARRRLVRPNQTIGLRGLLNLGATCFMNCIVQALVHTPL 181
               ||        |..|..|..||..|.|||.:..:.|||||||:|||.|||||||||||.|||:
  Rat   355 QCSVPSLGEKYPTWETTKPELELLGHNPRRRRIASSFTIGLRGLINLGNTCFMNCIVQALTHTPI 419

  Fly   182 LSDYFMSDRHDCGSKSSHKCLVCEVSRLFQEFYSGSRSPLSLHRLLHLIWNHAKHLAGYEQQDAH 246
            |.|:|:||||.|...|...|||||:|.||:|.|||:.||...::||||:|.||:|||||.|||||
  Rat   420 LRDFFLSDRHRCEMPSPELCLVCEMSSLFRELYSGNPSPHVPYKLLHLVWIHARHLAGYRQQDAH 484

  Fly   247 EFFIATLDVLHRHCVKAKAEHESKSNSSGSGSGTNSSNSSSSHCYGQCNCIIDQIFTGMLQSDVV 311
            ||.||.||||||||             .|...|..:||.:      .|||||||||||.|||||.
  Rat   485 EFLIAALDVLHRHC-------------KGDDVGKVASNPN------HCNCIIDQIFTGGLQSDVT 530

  Fly   312 CQACNGVSTTYDPFWDISLDL-------------GETTTHG-----GVTPKTLIDCLERYTRAEH 358
            ||||:|||||.||.|||||||             .|::.:|     |||  ||.|||.|:||.||
  Rat   531 CQACHGVSTTIDPCWDISLDLPGSCTSFWPMSPGRESSLNGESHIPGVT--TLTDCLRRFTRPEH 593

  Fly   359 LGSAAKIKCSTCKSYQESTKQFSLRTLPSVVSFHLKRFEHSALIDRKISSFIQFPVEFDMTPFMS 423
            |||:|||||.:|:||||||||.:::.||.|..||.|||||||...|||:::|.||:|.||||||:
  Rat   594 LGSSAKIKCGSCQSYQESTKQLTMKKLPVVACFHFKRFEHSAKQRRKITTYISFPLELDMTPFMA 658

  Fly   424 EKK-------------NAYGDFRFSLYAVVNHVGTIDTGHYTAYVRHQKDTWVKCDDHVITMASL 475
            ..|             :...:.::||:|||||.||:::||||:::||.:|.|.||||.|||.||:
  Rat   659 SSKETRMNGQLQLPTNSGNNENKYSLFAVVNHQGTLESGHYTSFIRHHRDQWFKCDDAVITKASI 723

  Fly   476 KQVLDSEGYLLFYHKNVLEYE 496
            |.|||||||||||||.|||:|
  Rat   724 KDVLDSEGYLLFYHKQVLEHE 744

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
not	NP_001287106.1	zf-UBP	46..103	CDD:307999	23/57 (40%)
not	NP_001287106.1	Peptidase_C19D	158..489	CDD:239125	205/361 (57%)
Usp27x	XP_006256824.2	zf-UBP	268..328	CDD:396634	25/59 (42%)
Usp27x	XP_006256824.2	Peptidase_C19D	396..737	CDD:239125	205/361 (57%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	416	1.000	Domainoid score	I637
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	534	1.000	Inparanoid score	I1162
OMA	1	1.010	-	-		QHG59954
OrthoDB	1	1.010	-	-		D200191at33208
OrthoFinder	1	1.000	-	-		FOG0002382
OrthoInspector	1	1.000	-	-		otm45217
orthoMCL	1	0.900	-	-		OOG6_102914
Panther	1	1.100	-	-	O	PTHR21646
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X1575
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	12	11.980