DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment not and Usp5

DIOPT Version :9

Sequence 1:	NP_001287106.1	Gene:	not / 40030	FlyBaseID:	FBgn0013717	Length:	496	Species:	Drosophila melanogaster
Sequence 2:	NP_001100089.1	Gene:	Usp5 / 297593	RGDID:	1308438	Length:	858	Species:	Rattus norvegicus

Alignment Length:	427	Identity:	84/427 - (19%)
Similarity:	150/427 - (35%)	Gaps:	120/427 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    64 YFGCRGA--HITSHLRSKKHNVALELSHGTL-------YCYACRDFIYDARSREYALINRKLEAK 119
            ||...|.  |...|.|...:.:|::|  ||:       |.|...|.:.|....|: |.:..::..
  Rat   223 YFDGSGGNNHAVEHYRETGYPLAVKL--GTITPDGADVYSYDEDDMVLDPSLAEH-LSHFGIDML 284

  Fly   120 DLQKSIGWVPWVPTTKETNLLLANARRRL------------VRPNQTIGLRGLLNLGATCFMNCI 172
            .:||         |.|....|..:..:|:            ::|....|..|:.|||.:|::|.:
  Rat   285 KMQK---------TDKTMTELEIDMNQRIGEWELIQESGVPLKPLFGPGYTGIRNLGNSCYLNSV 340

  Fly   173 VQALVHTP--------LLSDYFMS-------DRHDCGSKSSHKCLVCEVSRLFQEFYSGSRSP-- 220
            ||.|...|        .|...|.:       |.....:|..|..|..|.|:...|...|.:.|
  Rat   341 VQVLFSIPDFQRKYVDKLEKIFQNAPTDPTQDFSTQVAKLGHGLLSGEYSKPALESGDGEQVPEQ 405

  Fly   221 ------LSLHRLLHLIWNHAKHLAGYEQQDAHEFFIATLDVLHRHCVKAKAEHESKSNSSGSGSG 279
                  ::......||.......:...||||.|||:..::::.|:|
  Rat   406 KEVQDGIAPRMFKALIGKGHPEFSTNRQQDAQEFFLHLINMVERNC------------------- 451

  Fly   280 TNSSNSSSSHCYGQCNCIIDQIFTGMLQSDVVCQACNGVSTTYDPFWDISLDLGETTTHGGVTPK 344
            .:|.|.             :::|..:::..:.|.|...|..|....:.:.|.:   .....:..:
  Rat   452 RSSENP-------------NEVFRFLVEEKIKCLATEKVKYTQRVDYIMQLPV---PMDAALNKE 500

  Fly   345 TLIDCLERYTRAEHLGSA------AKIKCSTC--------------------KSYQESTKQFSLR 383
            .|::..|:..:||....|      |::..|:|                    ||....|.:|:
  Rat   501 ELLEYEEKKRQAEEEKVALPELVRAQVPFSSCLEAYGAPEQVDDFWSTALQAKSVAVKTTRFA-- 563

  Fly   384 TLPSVVSFHLKRFEHSA-LIDRKISSFIQFPVEFDMT 419
            :.|..:...:|:|.... .:.:|:...|:.|.|.|::
  Rat   564 SFPDYLVIQIKKFTFGLDWVPKKLDVSIEMPEELDIS 600

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
not	NP_001287106.1	zf-UBP	46..103	CDD:307999	13/47 (28%)
not	NP_001287106.1	Peptidase_C19D	158..489	CDD:239125	60/312 (19%)
Usp5	NP_001100089.1	UBP14	18..855	CDD:227532	84/427 (20%)
		zf-UBP	199..272	CDD:280334	14/50 (28%)
		Peptidase_C19B	327..854	CDD:239123	60/311 (19%)
		UBA1_UBP5	655..702	CDD:270566
		UBA2_UBP5	723..765	CDD:270569
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910