DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment not and Usp8

DIOPT Version :9

Sequence 1:	NP_001287106.1	Gene:	not / 40030	FlyBaseID:	FBgn0013717	Length:	496	Species:	Drosophila melanogaster
Sequence 2:	NP_001099972.1	Gene:	Usp8 / 296121	RGDID:	1304979	Length:	1081	Species:	Rattus norvegicus

Alignment Length:	418	Identity:	125/418 - (29%)
Similarity:	195/418 - (46%)	Gaps:	51/418 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly   105 RSREYALINRKLEAKD----LQKSIGWVPWV-PTTK-----------ETNLLLANARRRLVRPNQ 153
            |.||.:.:.|...:.|    ||:.....|.| ||..           |.:.|.|:..|.|   |.
  Rat   669 RDREPSKLKRSYSSPDITQALQEEEKRRPAVTPTVNRENKPPCYPKAEISRLSASQIRNL---NP 730

  Fly   154 TIG-----LRGLLNLGATCFMNCIVQALVHTPLLSDYF----MSDRHDCGSKSSHKCLVC-EVSR 208
            ..|     |.||.|||.||:||.|:|.|.:.|.|:|||    ..|..:..:...||..|. |...
  Rat   731 VFGGSGPALTGLRNLGNTCYMNSILQCLCNAPHLADYFNRNCYQDDINRSNLLGHKGEVAEEFGI 795

  Fly   209 LFQEFYSGSRSPLSLHRLLHLIWNHAKHLAGYEQQDAHEFFIATLDVLHRHCVKA--KAEHESKS 271
            :.:..::|....:|.......|.......||..|||:.|..:..:|.||....||  :..|:.::
  Rat   796 IMKALWTGQYRYISPKDFKVTIGKINDQFAGSSQQDSQELLLFLMDGLHEDLNKADNRKRHKEEN 860

  Fly   272 NSSGSGSGTNSSNSSSSHC---YGQCN-CIIDQIFTGMLQSDVVCQACNGVSTTYDPFWDISLDL 332
            |..      .....::.|.   :.|.| .||..:|.|..:|.|.|..|:..|.|::.|..:||.|
  Rat   861 NDH------LDDFKAAEHAWQKHKQLNESIIVALFQGQFKSTVQCLTCHKKSRTFEAFMYLSLPL 919

  Fly   333 GETTTHGGVTPKTLIDCLERYTRAEHLGSAAKIKCSTCKSYQESTKQFSLRTLPSVVSFHLKRFE 397
            ..|      :..||.|||..:::.|.|....:..||.|::.::|.|:..:..||.|:..|||||.
  Rat   920 AST------SKCTLQDCLRLFSKEEKLTDNNRFYCSHCRARRDSLKKIEIWKLPPVLLVHLKRFS 978

  Fly   398 HSALIDRKISSFIQFPVE-FDMTPFMSEKKNAYGDFRFSLYAVVNHVGTIDTGHYTAYVRH-QKD 460
            :.....:|:.:.:.||:| .|::.::...|::..  :::|::|.||.|.:|.||||||.:: .:.
  Rat   979 YDGRWKQKLQTSVDFPLENLDLSQYVIGPKSSLK--KYNLFSVSNHYGGLDGGHYTAYCKNAARQ 1041

  Fly   461 TWVKCDDHVITMASLKQVLDSEGYLLFY 488
            .|.|.|||.::..|:..|..|..|:|||
  Rat  1042 RWFKFDDHEVSDISVSSVRSSAAYILFY 1069

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
not	NP_001287106.1	zf-UBP	46..103	CDD:307999
not	NP_001287106.1	Peptidase_C19D	158..489	CDD:239125	106/344 (31%)
Usp8	NP_001099972.1	USP8_dimer	6..115	CDD:401063
		Radial_spoke_3	<80..>160	CDD:399236
		Rhodanese	193..304	CDD:395463
		PTZ00121	<453..610	CDD:173412
		UCH	740..1069	CDD:395355	104/342 (30%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910