DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment not and Usp39

DIOPT Version :9

Sequence 1:	NP_001287106.1	Gene:	not / 40030	FlyBaseID:	FBgn0013717	Length:	496	Species:	Drosophila melanogaster
Sequence 2:	XP_006506279.1	Gene:	Usp39 / 28035	MGIID:	107622	Length:	573	Species:	Mus musculus

Alignment Length:	532	Identity:	116/532 - (21%)
Similarity:	190/532 - (35%)	Gaps:	159/532 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly    35 DARERKAIHCNCFE--------------CG---SYGIQLYACLHC-IYFGCRG--AHITSHLRSK 79
            |:.:|::.||...:              |.   |: |..||||.| .||..||  :|...|....
Mouse    95 DSEDRRSRHCPYLDTINRSVLDFDFEKLCSISLSH-INAYACLVCGKYFQGRGLKSHAYIHSVQF 158

  Fly    80 KHNVALELSHGTLYCYACRDFIYDARSREYALINRKLEAKDLQKSIGWVPWVPTTKETNLLLANA 144
            .|:|.|.|.  ||..|...|        .|.:|:..||      .|.:| ..||..:..:...:.
Mouse   159 SHHVFLNLH--TLKFYCLPD--------NYEIIDSSLE------DITYV-LKPTFTKQQIANLDK 206

  Fly   145 RRRLVR----PNQTIGLRGLLNLGATCFMNCIVQALVHTPLLSDYFMSDRHDCGSKSSHKCLVCE 205
            :.:|.|    .....|:.||.|:.|..:.|.::|||.:.|.|.:||:.
Mouse   207 QAKLSRAYDGTTYLPGIVGLNNIKANDYANAVLQALSNVPPLRNYFLE----------------- 254

  Fly   206 VSRLFQEFYSGSRSP------LSLHR---LLHLIW---NHAKHLAGYE----------------- 241
                 ::.|...:.|      |.:.|   |:..:|   |...|::.:|
Mouse   255 -----EDNYKNIKRPPGDIMFLLVQRFGELMRKLWNPRNFKAHVSPHEMLQAVVLCSKKTFQITK 314

  Fly   242 QQDAHEFFIATLDVLHRHCVKAKAEHESKSNSSGSGSGTNSSNSSSSHCYGQCNCIIDQIFTGML 306
            |.|..:|....|:.||                |..| ||.....:          |::.:|.|.:
Mouse   315 QGDGVDFLSWFLNALH----------------SALG-GTKKKKKT----------IVNDVFQGSM 352

  Fly   307 QSDVVCQACNGVSTTYDPFWDISLDLGETTTHGGVTPKTLIDCLERYTRAEHLGSA--------- 362
            :          :.|...|..|:..:..|...|.....:|:::....|...: |.:|
Mouse   353 R----------IFTKKLPHPDLPAEEKEQLLHNDEYQETMVESTFMYLTLD-LPTAPLYKDEKEQ 406

  Fly   363 ------------AKIKCST---CKSYQES-TKQFSLRTLPSVVSFHLKRFEHSALIDRKISSFIQ 411
                        ||....|   .|:|:|: .|:|.|..||..:.|.:|||..:.....|..:.:.
Mouse   407 LIIPQVPLFNILAKFNGITEKEYKTYKENFLKRFQLTKLPPYLIFCIKRFTKNNFFVEKNPTIVN 471

  Fly   412 FPV-EFDMTPFMSEKKNA-YGDFRFSLYAVVNHVGTIDTGHYTAYV-RHQKDTWVKCDDHVITMA 473
            ||: ..|:..::||:..| :.:..:.|.|.:.|.|....|.|..:| .|....|.:..|..:|..
Mouse   472 FPITNVDLREYLSEEVQAVHKNTTYDLIANIVHDGKPSEGSYRIHVLHHGTGKWYELQDLQVTDI 536

  Fly   474 SLKQVLDSEGYL 485
            ..:.:..||.|:
Mouse   537 LPQMITLSEAYI 548

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
not	NP_001287106.1	zf-UBP	46..103	CDD:307999	22/76 (29%)
not	NP_001287106.1	Peptidase_C19D	158..489	CDD:239125	79/385 (21%)
Usp39	XP_006506279.1	PRK04537	<3..93	CDD:235307
Usp39	XP_006506279.1	Peptidase_C19M	105..550	CDD:239134	112/522 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910