Protein Alignment not and USP49

DIOPT Version :9

• Sequence 1: NP_001287106.1
• Gene: not / 40030
• FlyBaseID: FBgn0013717
• Length: 496
• Species: Drosophila melanogaster
• Sequence 2: NP_001273483.1
• Gene: USP49 / 25862
• HGNCID: 20078
• Length: 688
• Species: Homo sapiens
• Alignment Length: 653
• Identity: 151/653 - (23%)
• Similarity: 226/653 - (34%)
• Gaps: 222/653 - (33%)

  Fly    46 CFECGSYGIQLYACLHCIYFGCRGA----HITSHLRSKKHNVALELSHGTLYCYACRDFI----- 101
            |.||.:.. .::|||.|.:..| |.    |...|.....|.:|:|:....::||.|:|::
Human    26 CLECATTE-SVWACLKCSHVAC-GRYIEDHALKHFEETGHPLAMEVRDLYVFCYLCKDYVLNDNP 88

  Fly   102 ----------------------------------------------------------------- 101
                                                                             
Human    89 EGDLKLLRSSLLAVRGQKQDTPVRRGRTLRSMASGEDVVLPQRAPQGQPQMLTALWYRRQRLLAR 153

  Fly   102 ---------------YDARSREYALINRKLEAKDLQKSI-----GWVPWVPTTKETNLLLANAR- 145
                           .:.|.:|.||..:|.||:..::.:     ..:...|..|...|||...|
Human   154 TLRLWFEKSSRGQAKLEQRRQEEALERKKEEARRRRREVKRRLLEELASTPPRKSARLLLHTPRD 218

  Fly   146 --------------RRLV--------RPNQTIGLRGLLNLGATCFMNCIVQALVHTPLLSDYFM- 187
                          ||:.        :|....|:.||.|||.||:||.|:|.|.|.....:.|:
Human   219 AGPAASRPAALPTSRRVPAATLKLRRQPAMAPGVTGLRNLGNTCYMNSILQVLSHLQKFRECFLN 283

  Fly   188 -----------------------------------SDRHDCGSK--------------------- 196
                                               :||.:...:
Human   284 LDPSKTEHLFPKATNGKTQLSGKPTNSSATELSLRNDRAEACEREGFCWNGRASISRSLELIQNK 348

  Fly   197 ---SSHKCLVCEVSRLFQEFYSGSRSPLSLHRLLHLIWNHAKHLAGYEQQDAHEFFIATLDVLHR 258
               |.|..|..|:..||:..:||..:.:|...:||.:|:......||:||||.||.   .::||
Human   349 EPSSKHISLCRELHTLFRVMWSGKWALVSPFAMLHSVWSLIPAFRGYDQQDAQEFL---CELLH- 409

  Fly   259 HCVKAKAEHESKSNSSGSGSGTNSS---NSSSSHCYGQCNCIIDQIFTGMLQSDVVCQACNGVST 320
               |.:.|.||:        ||...   ..|......|...:::.||.|.|.|.|.|.:||..|.
Human   410 ---KVQQELESE--------GTTRRILIPFSQRKLTKQVLKVVNTIFHGQLLSQVTCISCNYKSN 463

  Fly   321 TYDPFWDISLDLGET--TTHGGVTPKTLIDC-----LERYTRAEHLGSAAKIKCSTCKS------ 372
            |.:||||:||:..|.  ....|..|....:|     |.::|..|.| ......|..|.|
Human   464 TIEPFWDLSLEFPERYHCIEKGFVPLNQTECLLTEMLAKFTETEAL-EGRIYACDQCNSKRRKSN 527

  Fly   373 -----YQESTKQFSLRTLPSVVSFHLKRFEHSALIDR-KISSFIQFPVEFDMTPFMSEKKNAYGD 431
                 ..|:.||..:..||.|:..|||||..|....| ||...:.|.....|.|:......:..|
Human   528 PKPLVLSEARKQLMIYRLPQVLRLHLKRFRWSGRNHREKIGVHVVFDQVLTMEPYCCRDMLSSLD 592

  Fly   432 ---FRFSLYAVVNHVGT-IDTGHYTAYVRH-QKDTWVKCDDHVITMASLKQVLDSEGYLLFYHKN 491
               |.:.|.|||.|.|. ..:||||||..: :...||.|:|..:.:.|:::|..::.|:|||.:.
Human   593 KETFAYDLSAVVMHHGKGFGSGHYTAYCYNTEGGFWVHCNDSKLNVCSVEEVCKTQAYILFYTQR 657

  Fly   492 VLE 494
            .::
Human   658 TVQ 660

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
not	NP_001287106.1	zf-UBP	46..103	CDD:307999	18/145 (12%)
		Peptidase_C19D	158..489	CDD:239125	115/417 (28%)
USP49	NP_001273483.1	zf-UBP	26..87	CDD:396634	18/62 (29%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	169..230		13/60 (22%)
		UCH	253..654	CDD:395355	114/416 (27%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	293..315		0/21 (0%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1867
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810