DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment not and ubp8

DIOPT Version :9

Sequence 1:	NP_001287106.1	Gene:	not / 40030	FlyBaseID:	FBgn0013717	Length:	496	Species:	Drosophila melanogaster
Sequence 2:	NP_592992.1	Gene:	ubp8 / 2542135	PomBaseID:	SPAC13A11.04c	Length:	449	Species:	Schizosaccharomyces pombe

Alignment Length:	509	Identity:	154/509 - (30%)
Similarity:	235/509 - (46%)	Gaps:	94/509 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 GCRHYQSYVKEHSYDTFRVIDAYFAAC--VNRDARERKAIHCNCFECGSYGIQLYACLHCIYFGC 67
            ||:|.:  :|....:.::.|.....:|  |.|          .|..|.....:...||.|...||
pombe     7 GCQHLK--LKPADVENYQKICTQIFSCHFVPR----------RCSTCKRINKRSIRCLSCHSVGC 59

  Fly    68 R-GAHITSHLRSKKHNVALELSHGTLYCYACRDFIY--DARSREYALINRKLEAKDLQKSIGWVP 129
            . |.|...|.....|.:.:::.:|..||:.|:|::|  :..:..:.:.|.|....|.::
pombe    60 LWGHHGEEHAMEHTHMIGVDVKNGHTYCFGCQDYVYQTELETLRFKIKNIKAWQSDHKR------ 118

  Fly   130 WVPTTKETNLLLANARRRLVRPNQTIGLRGLLNLGATCFMNCIVQALVHTPLLSDYFMSDRH--- 191
             :| .|...::...|.|:......|.||||:.||||||||:.|:|:::|.||:.:.|.|..|
pombe   119 -LP-EKYNQMVCLEAYRKYPPVCATAGLRGIQNLGATCFMSVILQSILHNPLVRNLFFSGFHTST 181

  Fly   192 DCGSKSSHKCLVCEVSRLFQEFYSGSRSPLSLH---RLLHLIWNHAKHLAGYEQQDAHEFFIATL 253
            ||...:   |:.|.:..:|...|: |::..:.:   .:|:|:|..:|.|.||.|||.||||:..|
pombe   182 DCKRPT---CMTCAIDDMFSSIYN-SKNKSTFYGPTAVLNLMWKLSKSLCGYSQQDGHEFFVYLL 242

  Fly   254 DVLHRHCVKAKAEHESKSNSSGSGSGTNSSNSSSSHCYGQCNCIIDQIFTGMLQSDVVCQACNGV 318
            |.:|                :.||.||:.          .|.|.|.:||:|.|::.|.|..|...
pombe   243 DQMH----------------TESGGGTSM----------PCTCPIHRIFSGSLKNVVTCLDCKKE 281

  Fly   319 STTYDPFWDISLDLGETTTHGGVTPKTLIDCLERYTRAEHLGSAAKIKCSTCKSYQESTKQFSLR 383
            ....||..|||||:.|.|..|         ||||:...|.:    :..|.:|.| :.:.||....
pombe   282 RVAVDPLMDISLDINEPTLQG---------CLERFVSKEKV----QYSCHSCGS-KNAIKQLVFD 332

  Fly   384 TLPSVVSFHLKRFEH-----SALIDRKIS--SFIQFPVEFDMTPFMSEKKNAYGDFRFSLYAVVN 441
            .||..:...|||||.     |..||:::|  :|::....|:.           .|..:.||:||.
pombe   333 KLPPTICMQLKRFEQNNFAMSTKIDKQVSYPAFLRMRYNFNQ-----------DDVDYQLYSVVC 386

  Fly   442 HVGTIDTGHYTAYVRHQKDTWVKCDDHVITMASLKQVLDSEGYLLFYHKNVLEY 495
            |.||:|||||.||..:| :.|...||..|......:||:|:.||||||:..:.|
pombe   387 HKGTLDTGHYIAYTYYQ-NQWFLLDDTTIVEVKESEVLNSQAYLLFYHERQILY 439

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
not	NP_001287106.1	zf-UBP	46..103	CDD:307999	17/59 (29%)
not	NP_001287106.1	Peptidase_C19D	158..489	CDD:239125	116/343 (34%)
ubp8	NP_592992.1	ZnF_UBP	37..85	CDD:197632	12/47 (26%)
		UCH	144..432	CDD:278850	116/343 (34%)
		Peptidase_C19D	145..433	CDD:239125	116/343 (34%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	176	1.000	Domainoid score	I851
eggNOG	1	0.900	-	-		E1_KOG1867
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H52664
Inparanoid	1	1.050	217	1.000	Inparanoid score	I924
OMA	1	1.010	-	-		QHG59954
OrthoFinder	1	1.000	-	-		FOG0002382
OrthoInspector	1	1.000	-	-		oto101051
orthoMCL	1	0.900	-	-		OOG6_102914
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1591
SonicParanoid	1	1.000	-	-		X1575
TreeFam	1	0.960	-	-
	13	12.760