DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment not and ubp7

DIOPT Version :9

Sequence 1:	NP_001287106.1	Gene:	not / 40030	FlyBaseID:	FBgn0013717	Length:	496	Species:	Drosophila melanogaster
Sequence 2:	NP_593108.1	Gene:	ubp7 / 2541845	PomBaseID:	SPAC23G3.08c	Length:	875	Species:	Schizosaccharomyces pombe

Alignment Length:	855	Identity:	165/855 - (19%)
Similarity:	243/855 - (28%)	Gaps:	406/855 - (47%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 CRHYQSYVK-EHSYDTFRVIDAYFAACVNRDARERKAIHCNCFECGSYGI-----QLYACLHCIY 64
            |.|.:..|| .|.....|.:         ||..:..     ||.|.:..|     :|..|.:|.|
pombe    56 CSHLKKGVKLSHLKGNARAL---------RDPSKHL-----CFICTTEKIKREDYELTLCANCGY 106

  Fly    65 FGC---RGAHITSHL-RSKKHNVALELSHGTLYCYACRDFIYDARSREYALINRK-LEAKDLQKS 124
            ..|   ...|...|. ::|||.|.:.:.....:||:|     ||   :..:.::| |..:|:|:.
pombe   107 LFCCNHESDHSRKHFEKNKKHCVFVNIITLKCHCYSC-----DA---DIVIFDKKNLVVRDVQQF 163

  Fly   125 IGWVPWVPTTKETNLLLANA------------------RRRLVRPNQTIGLRGLLNLGATCFMNC 171
            |........||..|:|.:|:                  :.:::.|       ||.|||||||.|.
pombe   164 ICSNLVSSLTKAPNVLKSNSSHFKKEKKSKHSSGKSSKKYKVISP-------GLKNLGATCFFNS 221

  Fly   172 IVQALVHTPLLSDYFMSDRHDCGS-------KSSHKCLVCEVSRLFQEFYSGSRSPLSLH----- 224
            .:|.|.....|.|.....::...|       ||....|:....:..:.||. |...:|::
pombe   222 TLQVLCACEALHDVISPFQYSHSSVIVRKLTKSPESSLLSAFIKFLETFYK-SDGTISVYRPTTF 285

  Fly   225 ----RLLHLIWNHAKHLAGYEQQDAHEFFIATLDVL----------------------------- 256
                |.||..::.:      .||||||.....||.|
pombe   286 FGEFRRLHPQFSES------VQQDAHELLRLLLDDLISEEFRVLRFNLNSVSRSLQLSPCLTDDE 344

  Fly   257 ----------------------------------------------------------------H 257
                                                                            |
pombe   345 QLSKSLTSFKQVNVTDASLSPNSHNTSDNEQNNEDYVSVSSLVGSETEDITYSKELSQSSDSSQH 409

  Fly   258 RH--------------CVKAKAEHESKSNSSGSG----------SGTNSSNSSSSHC-------- 290
            :|              ..|:....|...:||..|          :||||....:||.
pombe   410 QHDSFLPANSSPLAASSTKSLPSSELLDSSSDKGQQVFKGQHEVAGTNSFEDPNSHFNVSNSSNH 474

  Fly   291 ------------------------YGQ-----------------CNCIIDQIFTGMLQSDVVCQA 314
                                    .|:                 .:.:|..||||.|.|.|:||:
pombe   475 EEASPKKEVLKSPQFQRRSLDILRLGELSSDDMMLDKATMDEFSSSLVIKSIFTGRLTSVVMCQS 539

  Fly   315 CNGVSTTYDPFWDISL-------------------------------------------DLGETT 336
            ||.::.|.:|..|:|:                                           |...||
pombe   540 CNEITNTPEPIQDLSIPIHYPSSRVSRRHRFHRALRSRFSRSPKKSSVKIVVDNANDDTDQAPTT 604

  Fly   337 THGGVT----------------------------------------------------------- 342
            ....:.
pombe   605 NSSSLNENLLGGHASENDKSLKQSPFQKLTRRLSDLSVNSSGQISKQDFDNSNSIFSESSLSSPI 669

  Fly   343 ---PKTLIDCLERYTRAEHLGSAAKIKCSTC--------------------------KSYQESTK 378
               ||||||||:.:|..|.|.......|..|                          ..|:.:.|
pombe   670 IEEPKTLIDCLKNFTHVEELSGENMFACENCCNQPNEVGSPAKGGLTSDNDKYSFNNSVYRNAYK 734

  Fly   379 QFSL-RTLPSVVSFHLKRF----EHSALID-RKISSFIQFPVEFDMTPFMSEKKNAYGDFRFSLY 437
            :..| ..||.|...|||||    .|....: :|||.||:|..|.|:..|:.....|...||:.|:
pombe   735 RMLLDDPLPPVFIIHLKRFFQEISHDGYANPKKISDFIEFEQELDLNEFVMPHLRASSSFRYRLF 799

  Fly   438 AVVNHVGTIDTGHYTAYV------------RHQKD----------TWVKCDDHVITMASLKQVLD 480
            .|:.|.||::.|||.|||            .:.||          .|:...|:::..:|..:|..
pombe   800 GVIVHSGTLNYGHYVAYVLSHKFLDLSAPSTNSKDFRSEAGIPERRWLYISDNIVRESSWDEVSK 864

  Fly   481 SEGYLLFYHK 490
            .|.|:|||.:
pombe   865 VEAYMLFYER 874

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
not	NP_001287106.1	zf-UBP	46..103	CDD:307999	18/65 (28%)
not	NP_001287106.1	Peptidase_C19D	158..489	CDD:239125	125/671 (19%)
ubp7	NP_593108.1	zf-UBP	100..147	CDD:280334	15/54 (28%)
		Peptidase_C19	209..>306	CDD:271592	29/103 (28%)
		Peptidase_C19K	485..873	CDD:239132	78/387 (20%)
		UCH	<675..872	CDD:278850	55/196 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910